A5043376530- Toxoplasma gondii Research Studies
- Epigenetics and DNA Methylation
- Helminth infection and control
- Herpesvirus Infections and Treatments
- Parasite Biology and Host Interactions
- Cytomegalovirus and herpesvirus research
- Parasites and Host Interactions
- Coccidia and coccidiosis research
- Parasitic Infections and Diagnostics
- Animal Nutrition and Physiology
- Ubiquitin and proteasome pathways
- Advanced Glycation End Products research
- Identity, Memory, and Therapy
- Veterinary medicine and infectious diseases
- Genetics, Aging, and Longevity in Model Organisms
- Animal Disease Management and Epidemiology
- Genomics and Chromatin Dynamics
- Histone Deacetylase Inhibitors Research
- Vector-borne infectious diseases
- RNA modifications and cancer
- Microbial infections and disease research
- Cancer-related gene regulation
- Meat and Animal Product Quality
- Biochemical effects in animals
- Rabies epidemiology and control
Harvard University
2012-2025
Brigham and Women's Hospital
2007-2025
Huazhong Agricultural University
2016-2025
Chinese Academy of Agricultural Sciences
2025
Institute of Crop Sciences
2025
First People's Hospital of Yunnan Province
2024-2025
Hunan Academy of Traditional Chinese Medicine
2024
Zhejiang Medicine (China)
2024
Guangzhou Development Zone Hospital
2024
Nanjing Drum Tower Hospital
2024
Tumor-associated macrophages (TAMs) are a major component of leukocytic infiltrate in tumors, which facilitates tumor progression and promotes inflammation. TGF-β the differentiation non-activated into TAM-like (M2-like) phenotype; however, underlying mechanisms not clear. In this study, we found that induces M2-like phenotype characterized by up-regulation anti-inflammatory cytokine IL-10, down-regulation pro-inflammatory cytokines TNF-α IL-12. human THP-1 macrophages, overexpression SNAIL...
The long non-coding RNA (lncRNA) Xist is a master regulator of X-chromosome inactivation in mammalian cells. Models for how and other lncRNAs function depend on thermodynamically stable secondary higher-order structures that RNAs can form the context cell. Probing accessible bases provide data to build models conformation insight into function, molecular evolution, modularity. To study structure cells, we built upon recent advances mapping modeling develop Targeted Structure-Seq, which...
Acute lung injury (ALI) is a common clinical disease with high morbidity in both humans and animals. Ginsenoside Rg3, type of traditional Chinese medicine extracted from ginseng, widely used to cure many inflammation-related diseases. However, the specific molecular mechanism effects ginsenoside Rg3 on inflammation has rarely been reported. Thus, we established mouse model lipopolysaccharide (LPS)-induced ALI investigate immune protective explore its mechanism. In wild (WT) mice, found that...
Toxoplasma gondii is a widespread intracellular pathogen infecting humans and variety of animals. Previous studies have shown that uses glucose glutamine as the main carbon sources to support asexual reproduction, but neither nutrient essential. Such metabolic flexibility may allow it survive within diverse host cell types. Here, by focusing on glycolytic enzyme pyruvate kinase (PYK) converts phosphoenolpyruvate (PEP) into pyruvate, we found can also utilize lactate alanine. We show...
The cupA gene cluster of Pseudomonas aeruginosa encodes components a putative fimbrial structure that enable this opportunistic human pathogen to form biofilms on abiotic surfaces. In P. , expression is repressed by MvaT, transcription regulator thought belong the H-NS family nucleoid-associated proteins typically function repressing transcription. Here, we present evidence MvaT controls phase-variable (ON/OFF) cluster. Using directed proteomic approach, show associates with related protein...
Abstract Background Chicken coccidiosis is an intracellular parasitic disease that presents major challenges to the development of commercial poultry industry. Perennial drug selective pressure has led multi-drug resistance chicken coccidia, which makes prevention and control extremely difficult. In recent years, natural plant products have attracted attention researchers due their inherent advantages, such as absence veterinary residues. The these provides a new direction for treatment...
Abstract Background Haemonchus contortus (order Strongylida) is a common parasitic nematode infecting small ruminants and causing significant economic losses worldwide. Knowledge of genetic variation within among H. populations can provide foundation for understanding transmission patterns, the spread drug resistance alleles might assist in control haemonchosis. Methods 152 individual adult worms were collected from seven different geographical regions China. The second internal transcribed...
Avian coccidiosis is an intracellular intestinal parasitic disease, caused by parasites from the genus Eimeria, among which Eimeria tenella one of most pathogenic species and causes great economic losses. Frequent applications anticoccidial drugs have resulted in development drug-resistance E. tenella. In present study, we sought to determine genetic diversity isolates prevalent chicken farms Hubei Province China examine their sensitivity three drugs. The results provide useful information...