A5100332186- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Immune cells in cancer
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Breast Cancer Treatment Studies
- DNA Repair Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Breast Lesions and Carcinomas
- Extracellular vesicles in disease
- PARP inhibition in cancer therapy
- Blood Pressure and Hypertension Studies
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Cardiovascular Function and Risk Factors
- Phagocytosis and Immune Regulation
- Cardiovascular Health and Disease Prevention
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
Chengdu Medical College
2025
University Hospital Regensburg
2025
Chengdu Third People's Hospital
2023-2025
Nanjing Medical University
2015-2025
Nanjing University of Chinese Medicine
2023-2025
Harbin Engineering University
2025
The University of Texas Southwestern Medical Center
2023-2025
Beijing Children’s Hospital
2024-2025
Capital Medical University
2024-2025
Emory University
2025
Tamoxifen is the most commonly used endocrine therapy for patients with hormone receptor (HR)-positive breast cancer. Despite its initial therapeutic efficacy, many eventually develop drug resistance, which remains a serious clinical challenge. To investigate roles of circular RNAs (circRNAs) in tamoxifen tamoxifen-resistant MCF-7 cell line was established and screened circRNA expression profile by RNA sequencing. hsa_circ_0025202, that significantly downregulated, selected further...
Abstract Background Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are aberrantly expressed various cancers. However, the functional of lncRNAs breast cancer remain largely unknown. Methods Based on public databases integrating bioinformatics analyses, overexpression lncRNA BCRT1 tissues was detected further validated a cohort tissues. The effects proliferation, migration, invasion macrophage polarization were determined by vitro vivo experiments. Luciferase...
Background/Aims: Recent studies have indicated that exosomes secreted from adipose-derived stem cells (ADSCs) important effects in the treatment of ischemic injury. However, mechanism is unclear. This study aimed to investigate whether ADSC-derived enriched with microRNA (miR)-30d-5p a protective effect on acute stroke (AIS). Methods: In current study, inflammatory factors and miR-30d-5p expression were assessed 70 subjects AIS 35 healthy controls. Exosomes characterized by transmission...
Abstract Rapid proliferation and metastasis of breast cancers resulted in poor prognosis clinic. Recent studies have proved that long noncoding RNAs (lncRNAs) were involved tumor progression. In this study, we aimed to determine the roles mechanisms lncRNA–cell division cycle 6 (CDC6) regulating cancer. Clinically, lncRNA–CDC6 was highly expressed tissues positively correlated with clinical stages cancers. Functionally, ectopic expression promoted via regulation G1 phase checkpoint, further...
Approximately 10% of bone fractures do not heal satisfactorily, leading to significant clinical and socioeconomic implications. Recently, the role macrophages in regulating marrow stem cell (BMSC) differentiation through osteogenic pathway during fracture healing has attracted much attention. Methods: The tibial monocortical defect model was employed determine critical macrophage scavenger receptor 1 (MSR1) intramembranous ossification (IO) vivo. potential functions mechanisms MSR1 were...
The protein-coding ability of circular RNAs (circRNAs) has recently been a hot topic, but the expression and roles circRNAs in triple-negative breast cancer (TNBC) remain uncertain. By intersecting circRNA sequencing data from clinical samples cell lines, we identified circRNA, termed circ-EIF6, which predicted poorer prognosis correlated with clinicopathological characteristics cohort TNBC patients. Functionally, showed that circ-EIF6 promoted proliferation metastasis cells vitro vivo....
Abstract Chemo-resistance and metastasis of triple negative breast cancer (TNBC) contributed the most treatment failure in clinic. MicroRNAs (miRNAs) have been proved to be involved many biological processes diseases. In this study, we aimed determine role miR-770 regulation chemo-resistance TNBC. Clinically, was highly expressed chemo-sensitive tissues predicted a better prognosis Functionally, ectopic expression suppressed doxorubicin-resistance TNBC cell lines via apoptosis tumor...
Epithelial ovarian cancer (EOC) is still a major gynecologic problem with poor 5 year survival rate due to distance metastases, despite routine surgery and chemotherapy. The precise underlying molecular mechanisms that trigger EOC migration invasion are unclear. Recent studies suggest the expression of microRNAs widely dysregulated in cancer; they have evolved into tumorigenic processes, including cell proliferation, apoptosis motility. miR-124 was assessed clinical specimens lines using...
Abstract Triple-negative breast cancer (TNBC) is highly heterogeneous and has a poor prognosis. It therefore important to identify the underlying molecular mechanisms in order develop novel therapeutic strategies. Although emerging research revealed long noncoding RNAs (lncRNA) as vital carcinogenesis progression, their functional involvement TNBC not been well defined. In this study, we utilized The Cancer Genome Atlas (TCGA) database analyzed clinical samples show that antisense transcript...
Abstract Macrophage-orchestrated, low-grade chronic inflammation plays a pivotal role in obesity and atherogenesis. However, the underlying regulatory mechanisms remain incompletely understood. Here, we identify major vault protein (MVP), main component of unique cellular ribonucleoprotein particles, as suppressor for NF-κB signaling macrophages. Both global myeloid-specific MVP gene knockout aggravates high-fat diet induced obesity, insulin resistance, hepatic steatosis atherosclerosis...
Rationale: Doxorubicin-induced cardiomyopathy (DiCM) is a primary cause of heart failure and mortality in cancer patients, which macrophage-orchestrated inflammation serves as an essential pathological mechanism. However, the specific roles tissue-resident monocyte-derived macrophages DiCM remain poorly understood. Objective: Uncovering origins, phenotypes, functions proliferative cardiac resident mechanistic insights into self-maintenance macrophage during progression. Methods Results: Mice...
Recently, long noncoding RNAs (lncRNAs) have become the key gene regulators and prognostic biomarkers in various cancers. Through microarray data, Linc00339 was identified as a candidate oncogenic lncRNA. We compared expression levels of several breast cancer cell lines normal mammary gland epithelial line. The effects on tumor progression were examined both vitro vivo. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays applied to evaluate functions Linc00339, miR-377-3p,...
In this study, we investigated the mechanisms through which astrocyte-derived exosomes (AS-Exos) alleviate traumatic brain injury (TBI)-induced neuronal defects in TBI model rats and mice. Treatment with AS-Exos alleviated neurobehavioral deficits, cognitive impairment, edema rats. also significantly reduced cell loss atrophy oxidative stress mitochondrial H2O2 levels by increasing activity of antioxidant enzymes such as superoxide dismutase (SOD) catalase (CAT) hippocampal neurons...
Chronic inflammatory response plays a prominent role in obesity-related nonalcoholic fatty liver disease (NAFLD). However, the intrahepatic triggering mechanism of inflammation remains obscure. This study aimed to elucidate serum amyloid A1 (SAA1), an acute-phase protein, obesity-induced hepatic and NAFLD. Male mice were fed high fat diet (HFD) for 16 weeks, insulin resistance, steatosis, monitored. Murine SAA1/2 was genetically manipulated investigate SAA1 We found that increased NAFLD both...
Mitophagy, which selectively eliminates the dysfunctional and excess mitochondria by autophagy, is crucial for cellular homeostasis under stresses such as hypoxia. Dysregulation of mitophagy has been increasingly linked to many disorders including neurodegenerative disease cancer. Triple-negative breast cancer (TNBC), a highly aggressive subtype, reported be characterized However, role in hypoxic TNBC well underlying molecular mechanism largely unexplored. Here, we identified GPCPD1...
Orthodontic tooth movement (OTM), a process of alveolar bone remodelling, is induced by mechanical force and regulated local inflammation. Bone marrow-derived mesenchymal stem cells (BMSCs) play fundamental role in osteogenesis during OTM. Macrophages are mechanosensitive that can regulate inflammatory microenvironment promote BMSCs secreting diverse mediators. However, whether how regulates OTM via macrophage-derived exosomes remains elusive.Mechanical stimulation (MS) promoted macrophage...
Abstract The ATR kinase, which coordinates cellular responses to DNA replication stress, is also essential for the proliferation of normal unstressed cells. Although its role in stress response well defined, mechanisms by supports cell remain elusive. Here, we show that dispensable viability G0-arrested naïve B However, upon cytokine-induced proliferation, Atr-deficient cells initiate efficiently, but mid-S phase they display dNTP depletion, fork stalling, and failure. Nonetheless,...