A5052449364- Genetic Mapping and Diversity in Plants and Animals
- Plant Disease Resistance and Genetics
- Plant Pathogens and Fungal Diseases
- GABA and Rice Research
- Plant-Microbe Interactions and Immunity
- Rice Cultivation and Yield Improvement
- Plant Pathogenic Bacteria Studies
- Plant Virus Research Studies
- Genomics and Phylogenetic Studies
- Mycotoxins in Agriculture and Food
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Fungal Biology and Applications
- Agronomic Practices and Intercropping Systems
- Agricultural Systems and Practices
- Fungal and yeast genetics research
- Microbial Natural Products and Biosynthesis
- Plant Parasitism and Resistance
- Plant tissue culture and regeneration
- Genetic diversity and population structure
- Banana Cultivation and Research
- Plant and animal studies
- Microbial Metabolism and Applications
- Cell death mechanisms and regulation
- Biochemical and biochemical processes
Yunnan Agricultural University
2016-2025
China Pharmaceutical University
2024
Columbia University
2012-2023
Cancer Genetics (United States)
2012-2023
First Affiliated Hospital of Xi'an Jiaotong University
2017-2023
Tongji University
2022
Instituto de Ciencias Agrarias
2022
Yunnan Academy of Agricultural Sciences
2022
Dongbei University of Finance and Economics
2020-2021
National Center on Addiction and Substance Abuse at Columbia University
2017
Although several genes involved in mitochondrial function are direct Myc targets, the role of biogenesis has not been directly established. We determined effects ectopic expression or loss on biogenesis. Induction P493-6 cells resulted increased oxygen consumption and mass function. Conversely, compared to wild-type fibroblasts, null rat fibroblasts have diminished decreased number normal mitochondria. Reconstitution partially restored normal-appearing Concordantly, we also observed primary...
Abstract The role of Notch signaling in tumorigenesis can vary; Notch1 acts as an oncogene some neoplasms, and a tumor suppressor others. Here, we show that different receptors have opposite effects single type. Expression truncated, constitutively active or Notch2 embryonal brain cell lines caused antagonistic on growth. Cell proliferation, soft agar colony formation, xenograft growth were all promoted by inhibited Notch1. We also found receptor transcripts are highly expressed progenitor...
We elucidate grapevine evolution and domestication histories with 3525 cultivated wild accessions worldwide. In the Pleistocene, harsh climate drove separation of grape ecotypes caused by continuous habitat fragmentation. Then, occurred concurrently about 11,000 years ago in Western Asia Caucasus to yield table wine grapevines. The domesticates dispersed into Europe early farmers, introgressed ancient western ecotypes, subsequently diversified along human migration trails muscat unique...
Prediction of gene regulatory sequences using phylogenetic footprinting has advanced considerably but lacks experimental validation. Here, we report whether transcription factor binding sites predicted by dot plotting or web-based Trafac analysis could be validated chromatin immunoprecipitation assays. MYC overexpression enhances glycolysis without hypoxia and hence may contribute to altered tumor metabolism. Because the full spectrum glycolytic genes directly regulated Myc is not known,...
Abstract Purpose: Most breast cancers have chromosomal instability that seems related to defective mitotic spindle checkpoints. Because the molecular basis of this defect is unknown, we evaluated cancer cell lines and tissues for possible defects involving major checkpoint genes responsible maintaining stability. Experimental Design: We analyzed sequences expression levels (RNA protein) eight (MAD1L1, MAD2L1, MAD2L2, BUB1, BUB1B, BUB3, CDC20, TTK) in a panel 12 lines, most with established...
Several molecular and histopathological prognostic markers have been proposed for the therapeutic stratification of medulloblastoma patients. Amplification c-myc oncogene, elevated levels mRNA, or tumor anaplasia associated with worse clinical outcomes. In contrast, high TrkC mRNA expression generally presages longer survival. The goal this study was to evaluate value c-myc, N-myc in medulloblastomas compare them classification. We used situ hybridization measure these markers. detected 18...
Ataxia telangiectasia (A-T) mutated (ATM) kinase orchestrates deoxyribonucleic acid (DNA) damage responses by phosphorylating numerous substrates implicated in DNA repair and cell cycle checkpoint activation. A-T patients mouse models that express no ATM protein undergo normal embryonic development but exhibit pleiotropic defects. In this paper, we report mice carrying homozygous kinase-dead mutations Atm (AtmKD/KD) died during early development. AtmKD/− cells exhibited proliferation defects...
Establishing a fair and reasonable initial allocation scheme for carbon emission rights is prerequisite the efficient stable operation of market an important guarantee China to achieve its reduction target. This study considers historical transfer emissions measures cumulative net China's provinces based on principle consumer responsibility. It draws up plan in 2020, principles equity, efficiency, sustainability. The intensity efficiencies under this distribution were also evaluated. results...
Abstract The ATR kinase, which coordinates cellular responses to DNA replication stress, is also essential for the proliferation of normal unstressed cells. Although its role in stress response well defined, mechanisms by supports cell remain elusive. Here, we show that dispensable viability G0-arrested naïve B However, upon cytokine-induced proliferation, Atr-deficient cells initiate efficiently, but mid-S phase they display dNTP depletion, fork stalling, and failure. Nonetheless,...
Traditional farming practices suggest that cultivation of a mixture crop species in the same field through temporal and spatial management may be advantageous boosting yields preventing disease, but evidence from large-scale testing is limited. Increasing diversity intercropping addresses problem increasing land utilization productivity. In collaboration with farmers extension personnel, we tested tobacco, maize, sugarcane, potato, wheat broad bean – either by relay cropping or mixing based...
Abstract Fusarium wilt disease, caused by oxysporum f. sp. cubense , especially tropical race 4 ( Foc TR4), is threatening the global banana industry. Musa acuminata Pahang, a wild diploid that displays strong resistance to TR4, holds great potential understand underlying mechanisms. Microscopic examination reports that, in wounding inoculation system, TR4 infection processes roots of Pahang (resistant) and triploid cultivar Brazilian (susceptible) were similar 7 days post (dpi), but...
Rice black-streaked dwarf virus disease (RBSDVD) and southern rice (SRBSDVD) are the most destructive viral diseases in rice. Progress is limited breeding due to lack of resistance resource inadequate knowledge on underlying functional gene. Using genome-wide association study (GWAS), linkage disequilibrium (LD) decay analyses, RNA-sequencing, genome editing, we identified a highly RBSDVD-resistant variety its first A W44 was through extensive evaluation diverse international panel....
ABSTRACT Glutinous rice cultivars were sown after every fourth row of a nonglutinous, hybrid cultivar in an additive design. The glutinous 35 to 40 cm taller and substantially more susceptible blast than was the nonglutinous cultivar. Interplanting reduced incidence severity panicle on by >90%, 30 40%. Mixing increased per unit area yield 80 90% relative pure stand, whereas essentially unaffected mixing. To determine whether different plant heights canopy structures may contribute...
Bacterial leaf streak caused by Xanthomonas oryzae pv. oryzicola (Xoc) is one of the most important diseases in rice. However, little known about pathogenicity mechanisms Xoc. Here we have investigated function three HD-GYP domain regulatory proteins biofilm formation, synthesis virulence factors and Deletion rpfG resulted altered production extracellular polysaccharides (EPS), abolished on rice enhanced but had effect secretion proteases motility. In contrast, mutational analysis showed...
Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles cancer initiation and maintenance not clear. Here we report that CCL2 promotes mammary carcinoma development clinically relevant murine model breast Targeted disruption Ccl2 slowed the growth activated Her2/neu-driven prolonged host survival. Disruption was associated with decrease mobilization endothelial precursor cells (EPCs) which can...
In situ, on-farm conservation is an important complement to ex situ of traditional crop varieties. Yunnan Province, China, management for diversity by mixed planting (intercropping) and hybrid rice varieties provides a possible means sustainable Since the adoption this form in 1997, number cultivation has increased dramatically now includes some that were formerly locally extinct. The cultivated area also been greatly expanded. This easy implement links farmers' economic concerns with...