A5100673837- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Angiogenesis and VEGF in Cancer
- Cardiac Fibrosis and Remodeling
- Mesenchymal stem cell research
- Neonatal Respiratory Health Research
- Pancreatic function and diabetes
- Ginseng Biological Effects and Applications
- Pluripotent Stem Cells Research
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Congenital Heart Disease Studies
- Single-cell and spatial transcriptomics
- Liver physiology and pathology
- Cardiomyopathy and Myosin Studies
- Apelin-related biomedical research
- Pregnancy and preeclampsia studies
- Signaling Pathways in Disease
- Immune cells in cancer
- Renal and related cancers
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- RNA modifications and cancer
- Cardiovascular Function and Risk Factors
- Lipid metabolism and disorders
Center for Excellence in Molecular Cell Science
2016-2025
University of Chinese Academy of Sciences
2016-2025
ShanghaiTech University
2016-2025
Chinese Academy of Sciences
2016-2025
University of Hong Kong
2025
Shanghai Chest Hospital
2022-2025
Shanghai Jiao Tong University
2016-2025
Wuhan Children's Hospital
2025
Yingkou Institute of Technology
2025
Qingdao University
2025
Heart growth is tightly controlled so that the heart reaches a predetermined size. Fetal occurs through cardiomyocyte proliferation, whereas postnatal involves primarily physiological hypertrophy. The Hippo kinase cascade an important regulator of organ growth. A major target this YAP1, transcriptional coactivator inactivated by activity. Here, we used both genetic gain and loss Yap1 function to investigate its role in regulating proliferative physiologic hypertrophic inactivation caused...
The epicardium makes essential cellular and paracrine contributions to the growth of fetal myocardium formation coronary vasculature. However, whether has similar roles postnatally in normal injured heart remains enigmatic. Here, we have investigated this question using genetic fate-mapping approaches mice. In uninjured postnatal heart, epicardial cells were quiescent. Myocardial infarction increased cell proliferation stimulated epicardium-derived (EPDCs), which remained a thickened layer...
Rationale : Yes-associated protein (YAP), the terminal effector of Hippo signaling pathway, is crucial for regulating embryonic cardiomyocyte proliferation. Objective We hypothesized that YAP activation after myocardial infarction (MI) would preserve cardiac function and improve survival. Methods Results used a cardiac-specific, inducible expression system to activate in adult mouse heart. Activation heart promoted proliferation did not deleteriously affect function. Furthermore, MI...
The success of bortezomib therapy for treatment multiple myeloma (MM) led to the development structurally and pharmacologically distinct novel proteasome inhibitors. In present study, we evaluated efficacy one such orally bioactive inhibitor MLN9708/MLN2238 in MM using well-established vitro vivo models.MM cell lines, primary patient cells, human xenograft animal model were used study antitumor activity MN2238.Treatment cells with MLN2238 predominantly inhibits chymotrypsin-like induces...
Abstract The septum transversum mesenchyme (STM) signals to induce hepatogenesis from the foregut endoderm. Hepatic stellate cells (HSCs) are sinusoidal pericytes assumed originate STM and participate in mesenchymal-epithelial interaction embryonic adult livers. However, developmental origin of HSCs remains elusive due lack markers for HSCs. We previously identified submesothelial (SubMCs) beneath mesothelial (MCs) as a potential precursor developing In present study, we reveal that both day...
High salt is positively associated with the risk of many diseases. However, little known about mechanisms. Here we showed that high increased proinflammatory molecules, while decreased anti-inflammatory and proendocytic molecules in both human mouse macrophages. also potentiated lipopolysaccharide-induced macrophage activation suppressed interleukin 4-induced activation. induced aspects by activating p38/cFos and/or Erk1/2/cFos pathways, inhibited Erk1/2/signal transducer activator...
Abstract Mural cells of the vessel wall, namely pericytes and vascular smooth muscle cells, are essential for integrity. The developmental sources these molecular mechanisms controlling their progenitors in heart only partially understood. Here we show that endocardial endothelial murine embryonic heart. Endocardial undergo endothelial–mesenchymal transition convert into primitive mesenchymal expressing platelet-derived growth factor receptors, PDGFRα PDGFRβ. These migrate myocardium,...
The heart needs blood vessels, too For the newborn to grow quickly, heart's own vessels must as well. Researchers have assumed that preexisting fetal coronary expand cause this postnatal vascular growth. Instead, Tian et al. now show that, for most part, brandnew form within neonatal (see Perspective by Burns and Burns). This ability produce new after birth may one day help researchers work out how promote cardiovascular regeneration injury or disease. Science , issue p. 90 ; see also 28
Adult mammalian hearts have a limited ability to generate new cardiomyocytes. Proliferation of existing adult cardiomyocytes (ACMs) is potential source Understanding the fundamental biology ACM proliferation could be great clinical significance for treating myocardial infarction (MI). We aim understand process and regulation its role in cardiomyocyte formation post-MI mouse hearts.β-Actin-green fluorescent protein transgenic mice fate-mapping Myh6-MerCreMer-tdTomato/lacZ were used trace fate...
Organ homeostasis is orchestrated by time- and spatially restricted cell proliferation. Studies identifying cells with superior proliferative capacities often rely on the lineage tracing of a subset populations, which introduces potential selective bias. In this work, we developed genetic system [proliferation tracer (ProTracer)] incorporating dual recombinases to seamlessly record proliferation events entire populations over time in multiple organs. mouse liver, ProTracer revealed more...