A5100776327- Sleep and Wakefulness Research
- Laser-Plasma Interactions and Diagnostics
- Hair Growth and Disorders
- Zebrafish Biomedical Research Applications
- Ubiquitin and proteasome pathways
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Congenital heart defects research
- Laser-Matter Interactions and Applications
- Laser-induced spectroscopy and plasma
- Erythrocyte Function and Pathophysiology
- High-pressure geophysics and materials
- Renal and related cancers
- Wnt/β-catenin signaling in development and cancer
- Cell death mechanisms and regulation
- Prenatal Screening and Diagnostics
- Biochemical Analysis and Sensing Techniques
- Endoplasmic Reticulum Stress and Disease
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Regulation of Appetite and Obesity
- Hepatitis B Virus Studies
- Congenital Diaphragmatic Hernia Studies
- Fibroblast Growth Factor Research
- Phagocytosis and Immune Regulation
Tsinghua University
2019-2025
National Institute of Biological Sciences, Beijing
2016-2025
Tsukuba International University
2022
University of Tsukuba
2022
First Affiliated Hospital of Bengbu Medical College
2010-2020
Bengbu Medical College
2015
Shanghai Institute of Optics and Fine Mechanics
2007-2009
Chinese Academy of Sciences
2007-2009
University of Science and Technology of China
2007
Significance Pulmonary alveolar type I (AT1) cells are essential for the gas-exchange function of lungs. AT1 retain their cellular plasticity during injury-induced regeneration. However, we know very little about developmental heterogeneity cell population. Our study identified a robust genetic marker postnatal cells, insulin-like growth factor-binding protein 2 (Igfbp2). We use this to demonstrate that population actually consists two subtypes (Hopx + Igfbp2 and Hopx − cells) with distinct...
Hepatitis D virus (HDV) is the smallest known to infect human. About 15 million people worldwide are infected by HDV among those 240 its helper hepatitis B (HBV). Viral considered as one of most severe forms human viral hepatitis. No specific antivirals currently available treat infection and against HBV do not ameliorate D. Liver sodium taurocholate co-transporting polypeptide (NTCP) was recently identified a common entry receptor for in cell cultures. Here we show can mice expressing NTCP...
Biochemical studies suggest that the NAIP family of NLR proteins are cytosolic innate receptors directly recognize bacterial ligands and trigger NLRC4 inflammasome activation. In this study, we generated Naip5−/−, Naip1−/−, Naip2−/− mice showed bone marrow macrophages derived from these knockout specifically deficient in detecting flagellin, type III secretion system needle, rod protein, respectively. Naip2−/−, Naip5−/− also resist lethal activation by corresponding ligand. Furthermore,...
Glypican-3 (GPC3) is a well-characterized hepatocellular carcinoma (HCC)-associated antigen, yet anti-GPC3 therapies have achieved only minimal clinical progress. CD47 ubiquitously expressed innate immune checkpoint that promotes evasion of tumors from surveillance. Given both the specific expression GPC3 in HCC and known phagocytosis inhibitory effect liver cancer, we hypothesized bispecific antibody (BsAb) co-engages with may offer excellent antitumor efficacy toxicity. Here, generated...
Impaired differentiation of alveolar stem cells has been identified in a variety acute and chronic lung diseases. In this study, we investigate the mechanisms that modulate regeneration understand how aging impacts process. We have discovered process type II (AT2) differentiating into AT1 is an energetically costly During regeneration, activated AMPK-PFKFB2 signaling upregulates glycolysis, which essential to support intracellular energy expenditure required for cytoskeletal remodeling...
Sleep need accumulates during waking and dissipates sleep to maintain homeostasis (process S). Besides the regulation of daily (baseline) amount, homeostatic commonly refers universal phenomenon that deprivation (SD) causes an increase need, hence, amount intensity subsequent recovery sleep. The central regulators signaling pathways govern baseline regulations in mammals remain unclear. Here, we report enhanced activity calcineurin Aα (CNAα)—a catalytic subunit calcineurin—in mouse brain...
Long-term adult stem cells sustain tissue regeneration throughout the lifetime of an organism. They were hypothesized to originate from embryonic progenitor that acquire long-term self-renewal ability and multipotency at end organogenesis. The process through which this is achieved often remains unclear. Here, we discovered hair follicle arise occupying a niche location defined by attenuated Wnt/β-catenin signaling. Hair initiation marked placode formation, depends on activation Soon...
Abstract Background The antiphagocytic molecule CD47 is overexpressed in a wide variety of cancer cells, and antibodies targeting for therapies are currently under intensive investigation. However, owing to the ubiquitous expression on healthy anti-CD47 often achieve only weak therapeutic benefits can induce severe side effects. Here, we report generation pH-dependent antibody (BC31M4) which selectively binds tumors acidic solid tumor microenvironment. Methods BC31M4 was generated using...
A multiple-staged ion acceleration mechanism in the interaction of a circularly polarized laser pulse with solid target is studied by one-dimensional particle-in-cell simulation. The ions are accelerated from rest to several MeV monoenergetically at front surface target. After all plasma accelerated, process repeated on resulting monoenergetic ions. Under suitable conditions multiple repetitions can be realized and high-energy quasi-monoenergetic beam obtained.
Abstract Abnormal trophoblast self-renewal and differentiation during early gestation is the major cause of miscarriage, yet underlying regulatory mechanisms remain elusive. Here, we show that specific deletion Kat8 , a MYST family histone acetyltransferase, leads to extraembryonic ectoderm abnormalities embryonic lethality. Employing RNA-seq CUT&Tag analyses on stem cells (TSCs), further discover KAT8 regulates transcriptional activation stemness marker, CDX2, via acetylating H4K16....
Epigenetic reprogramming plays a central role in the development of cloned embryos generated by somatic cell nuclear transfer, and it is believed that aberrant leads to abnormal most embryos. Recent studies show trimethylation H3K27 (H3K27me3) contributes maintenance embryonic stem pluripotency because differentiation genes are always occupied nucleosomes trimethylated at H3K27, which represses gene expression. Here, we provide evidence differential H3K27me3 modification exists between...
Rotavirus is the leading cause of severe dehydrating diarrhea in young children and inner capsid protein VP6 a potential vaccine candidate that can induce cross-protective immune responses against different strains. The use ferritin nanoparticles as scaffold antigen improve immunogenicity subunit vaccines provide broader protection. We here present non-live self-assemble recombinant rotavirus VP6-ferritin (rVP6-ferritin) nanoparticle vaccine.The rVP6-ferritin were expressed E. coli...
Abstract Defective rhodopsin homeostasis is one of the major causes retinal degeneration, including disease Retinitis pigmentosa. To identify cellular factors required for biosynthesis rhodopsin, we performed a genome-wide genetic screen in Drosophila mutants with reduced levels rhodopsin. We isolated loss-of-function alleles endoplasmic reticulum membrane protein complex 3 ( emc3 ), emc5 , and emc6 each which exhibited defective phototransduction photoreceptor cell degeneration. EMC3, EMC5,...