A5037039959- Inflammasome and immune disorders
- Immune Response and Inflammation
- Streptococcal Infections and Treatments
- Toxoplasma gondii Research Studies
- Genital Health and Disease
- Autoimmune and Inflammatory Disorders Research
- Erythrocyte Function and Pathophysiology
- Galectins and Cancer Biology
- Ion Channels and Receptors
- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
- Escherichia coli research studies
- IL-33, ST2, and ILC Pathways
- interferon and immune responses
- Heme Oxygenase-1 and Carbon Monoxide
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pneumonia and Respiratory Infections
- Viral Infections and Outbreaks Research
National Institute of Biological Sciences, Beijing
2011-2019
Tsinghua University
2014-2015
Peking University
2014-2015
Immune activation in context Dendritic cells (DCs) initiate protective immunity upon binding molecules derived from microbes or released dying cells. Zanoni et al. examined how microbial and endogenous signals interact to shape the course of ensuing immune response (see Perspective by Napier Monack). They found that oxPAPC, an oxidized phospholipid cells, binds a protein called caspase-11 DCs, activating inflammatory program these Whereas oxPAPC bacterial lipopolysaccharide causes DCs...
Significance Our analyses uncover general immunogenic activity of bacterial T3SS needle protein and identify human NAIP mouse NAIP1 as cytosolic innate immune sensors protein. These results, together with our previous studies, establish a complete framework for understanding NLRC4-mediated detection virulence products by the family inflammasome receptors. The inflammasome-stimulating proteins difference between also may provide guidance in vaccine development.
Biochemical studies suggest that the NAIP family of NLR proteins are cytosolic innate receptors directly recognize bacterial ligands and trigger NLRC4 inflammasome activation. In this study, we generated Naip5−/−, Naip1−/−, Naip2−/− mice showed bone marrow macrophages derived from these knockout specifically deficient in detecting flagellin, type III secretion system needle, rod protein, respectively. Naip2−/−, Naip5−/− also resist lethal activation by corresponding ligand. Furthermore,...
The skewed molecular shape of the rigid α,α-(1↔1′)-linked disaccharide core novel synthetic anionic glycan-based immunostimulants is accountable for potent and adjustable TLR4-mediated signaling which dissociable from induction caspase-11 protease activity.
Abstract Innate immunity relies on the formation of different inflammasomes to initiate immune responses. The recognition diverse infection and other danger signals by innate receptors trigger caspase-1 activation that induces pyroptosis. Anthrax lethal factor (LF) is a secreted bacterial protease known potently activate Nlrp1b in mouse macrophages, but molecular mechanism underlying LF-induced remains unknown. We here carried out both genome-wide siRNA screen CRISPR/Cas9 knockout seeking...