A5082643388- Immune Response and Inflammation
- interferon and immune responses
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Influenza Virus Research Studies
- Viral Infections and Vectors
- IL-33, ST2, and ILC Pathways
- Antimicrobial Peptides and Activities
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Erythrocyte Function and Pathophysiology
- Legionella and Acanthamoeba research
- Cell death mechanisms and regulation
- Immune cells in cancer
- Cytomegalovirus and herpesvirus research
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
- Gout, Hyperuricemia, Uric Acid
- Neonatal Health and Biochemistry
- Phagocytosis and Immune Regulation
- Peroxisome Proliferator-Activated Receptors
- Mosquito-borne diseases and control
- Cancer Immunotherapy and Biomarkers
Boston Children's Hospital
2016-2025
Harvard University
2016-2025
National Institute of Allergy and Infectious Diseases
2024
Longwood University
2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2023
Boston Children's Museum
2013-2017
Yale University
2000-2008
Howard Hughes Medical Institute
2005
Emory University
2004
Shriners Hospitals for Children - Boston
2003
The intracellular pathogen Legionella pneumophila subverts vesicle traffic in eukaryotic host cells to create a vacuole that supports replication. dot/icm genes encode protein secretion apparatus L. require for biogenesis of this vacuole. Here we show produce called RalF functions as an exchange factor the ADP ribosylation (ARF) family guanosine triphosphatases (GTPases). is required localization ARF on phagosomes containing . Translocation through phagosomal membrane -dependent process....
Immune activation in context Dendritic cells (DCs) initiate protective immunity upon binding molecules derived from microbes or released dying cells. Zanoni et al. examined how microbial and endogenous signals interact to shape the course of ensuing immune response (see Perspective by Napier Monack). They found that oxPAPC, an oxidized phospholipid cells, binds a protein called caspase-11 DCs, activating inflammatory program these Whereas oxPAPC bacterial lipopolysaccharide causes DCs...
The MTOC is “speck”-tacular Inflammasome complexes are formed in response to pathogen-associated molecules. They initiate both the maturation of inflammatory cytokines and pyroptosis, a type programmed cell death. One notable feature for inflammasome activation formation single supramolecular punctum (or “speck”) each affected cell. However, location mechanism speck poorly understood. Magupalli et al. report that NLRP3- pyrin-mediated inflammasomes, their assembly downstream functions occur...
Critical to the design and assessment of interventions for enteropathy its developmental consequences in children living impoverished conditions are non-invasive biomarkers that can detect intestinal damage predict effects on growth development. We therefore assessed fecal, urinary systemic predictors 375 6-26 month-old with varying degrees malnutrition (stunting or wasting) Northeast Brazil. 301 these returned followup anthropometry after 2-6m. Biomarkers correlated stunting included plasma...
Stimulator of interferon genes (STING) is a key regulator type I and pro-inflammatory responses during infection, cellular stress, cancer. Here, we reveal mechanism for how STING balances activation IRF3- NF-κB-dependent transcription discover that acquisition discrete signaling modules in the vertebrate C-terminal tail (CTT) shapes downstream immunity. As defining example, identify motif appended to CTT zebrafish inverts typical response results dramatic NF-κB weak IRF3-interferon...