A5089717833- Immune Response and Inflammation
- Immune Cell Function and Interaction
- interferon and immune responses
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- T-cell and B-cell Immunology
- NF-κB Signaling Pathways
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Phagocytosis and Immune Regulation
- Immunodeficiency and Autoimmune Disorders
- Influenza Virus Research Studies
- Dermatology and Skin Diseases
- CRISPR and Genetic Engineering
- Allergic Rhinitis and Sensitization
- Antimicrobial Peptides and Activities
- Exercise and Physiological Responses
- Cytomegalovirus and herpesvirus research
- Advanced biosensing and bioanalysis techniques
- Bacterial Infections and Vaccines
- Kruppel-like factors research
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- IL-33, ST2, and ILC Pathways
University of California, Berkeley
2016-2025
Howard Hughes Medical Institute
1999-2025
University of the Witwatersrand
2019
Yale University
2001-2014
University of Washington
1998-2002
Fred Hutch Cancer Center
1999
Members of the Toll-like receptor (TLR) family recognize conserved microbial structures, such as bacterial lipopolysaccharide and viral double-stranded RNA, activate signaling pathways that result in immune responses against infections. All TLRs MyD88-dependent to induce a core set stereotyped responses, inflammation. However, individual can also are tailored given infection. Thus, these receptors involved both innate adaptive responses. The mechanisms components varied only partly...
Context shapes anticommensal immunity The gut bacterium Akkermansia muciniphila is associated with protection from obesity, enhanced wound healing, and augmented antitumor responses. Ansaldo et al. found that this microbe induces antigen-specific immunoglobulin G1 (IgG1) antibodies generated by B cells CD4 + T cell help. This in contrast to most responses, which involve the cell–independent production of IgA antibodies. In a gnotobiotic setting all components microbiome are defined, A....
Toll-like receptor (TLR) 9 requires proteolytic processing in the endolysosome to initiate signaling response DNA. However, recent studies conflict as which proteases are required for cleavage. We show that TLR9 proteolysis is a multistep process. The first step removes majority of ectodomain and can be performed by asparagine endopeptidase (AEP) or cathepsin family members. This initial cleavage event followed trimming solely mediated optimal signaling. dual requirement AEP cathepsins...
UNC93B1, a multipass transmembrane protein required for TLR3, TLR7, TLR9, TLR11, TLR12, and TLR13 function, controls trafficking of TLRs from the endoplasmic reticulum (ER) to endolysosomes. The mechanisms by which UNC93B1 mediates these regulatory effects remain unclear. Here, we demonstrate that enters secretory pathway directly packaging into COPII vesicles bud ER. Unlike other loading factors, remains associated with through post-Golgi sorting steps. Unexpectedly, steps are different...