A5038052167- Gut microbiota and health
- Probiotics and Fermented Foods
- Food Security and Health in Diverse Populations
- Pediatric Hepatobiliary Diseases and Treatments
- Digestive system and related health
- Diet and metabolism studies
- Infant Nutrition and Health
- Tryptophan and brain disorders
- Climate Change Communication and Perception
- Food composition and properties
- Intestinal Malrotation and Obstruction Disorders
- Evolutionary Game Theory and Cooperation
- Evolution and Genetic Dynamics
- Zoonotic diseases and public health
- Biochemical Analysis and Sensing Techniques
- Nutritional Studies and Diet
- Microbial Community Ecology and Physiology
- Diet, Metabolism, and Disease
- Public Health Policies and Education
- Ginger and Zingiberaceae research
- Microbial Metabolites in Food Biotechnology
- Drug Transport and Resistance Mechanisms
Duke University
2021-2025
Humans are inextricably linked to each other and our natural world, microorganisms lie at the nexus of those interactions. Microorganisms form genetically flexible, taxonomically diverse, biochemically rich communities, i.e., microbiomes that integral health development macroorganisms, societies, ecosystems.
The infant gut microbiome is a crucial factor in health and development. In preterm infants, altered composition function have been linked to serious neonatal complications such as necrotizing enterocolitis sepsis, which can lead long-term disability. Although many studies described links between disease risk, there need for biomarkers identify infants at risk of these practice. this pilot study, we obtained stool samples from participants longitudinally during the first postnatal months,...
Fructans are commonly used as dietary fibre supplements for their ability to promote the growth of beneficial gut microbes. However, fructan consumption has been associated with various dosage-dependent side effects. We characterised effects in an exploratory analysis a randomised trial healthy adults (
Abstract Akkermansia muciniphila, a prominent member of the gastrointestinal tract (GI) microbiota, uses mucins as sole source carbon and nitrogen. A. muciniphila is considered next-generation probiotic because its abundance in humans positively correlates with protection from metabolic syndrome obesity. However, intractable to genetic analysis thus molecular mechanisms underlying metabolism mucin, colonization GI tract, impact on host physiology are poorly understood. Here, we developed...
ABSTRACT Physical particles can serve as critical abiotic factors that structure the ecology of microbial communities. For non-human vertebrate gut microbiomes, fecal particle size (FPS) has been known to be shaped by chewing efficiency and diet. However, little is about what drives FPS in human gut. Here, we analyzed laser diffraction across a total 76 individuals found strongly individualized. Surprisingly, behavioral intervention with 41 volunteers designed increase did not impact FPS....
Physical particles can serve as critical abiotic factors that structure the ecology of microbial communities. For non-human vertebrate gut microbiomes, fecal particle size (FPS) has been known to be shaped by chewing efficiency and diet. However, little is about what drives FPS in human gut. Here, we analyzed laser diffraction across a total 76 individuals found strongly individualized. Contrary our initial hypothesis, behavioral intervention with 41 volunteers designed increase did not...
Abstract Many ecosystems retain an ecological memory of past conditions that affects responses to future stimuli. However, it remains unknown what mechanisms and dynamics may govern such a in microbial communities. Here, both human dietary intervention cohort artificial gut, we show the gut microbiome encodes carbohydrate exposures. Changes relative abundance primary degraders were sufficient enhance metabolism, these changes mediated by transcriptional within hours initial exposure. We...
ABSTRACT The infant gut microbiome is a crucial factor in health and development. In preterm infants, altered composition function have been linked to serious neonatal complications such as necrotizing enterocolitis sepsis, which can lead long-term disability. Although many studies described links between disease risk, there need for biomarkers identify infants at risk of these practice. this study, we obtained stool samples from participants longitudinally during the first postnatal months,...