A5006213992- Dermatology and Skin Diseases
- Gut microbiota and health
- Allergic Rhinitis and Sensitization
- Human-Animal Interaction Studies
- Zoonotic diseases and public health
- Infant Nutrition and Health
- Child Nutrition and Water Access
- Diet and metabolism studies
- Breastfeeding Practices and Influences
- Birth, Development, and Health
- Pediatric health and respiratory diseases
- Blood Pressure and Hypertension Studies
- Sodium Intake and Health
- Primate Behavior and Ecology
- Clostridium difficile and Clostridium perfringens research
- Asthma and respiratory diseases
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Public Health Policies and Education
- Metabolomics and Mass Spectrometry Studies
- Infant Health and Development
- Food Security and Health in Diverse Populations
- Sleep and related disorders
Northwestern University
2019-2024
The University of Texas at San Antonio
2024
Children's Hospital Research Institute of Manitoba
2023
University of Manitoba
2023
Duke University
2017-2018
Duke Institute for Health Innovation
2017-2018
Triangle
2018
Humans are inextricably linked to each other and our natural world, microorganisms lie at the nexus of those interactions. Microorganisms form genetically flexible, taxonomically diverse, biochemically rich communities, i.e., microbiomes that integral health development macroorganisms, societies, ecosystems.
We studied sleep in a rural population Madagascar to (i) characterize an equatorial small-scale agricultural without electricity, (ii) assess whether is linked noise levels dense population, and (iii) examine the effects of experimentally introduced artificial light on timing.Using actigraphy, sleep-wake patterns were analyzed for both daytime napping nighttime wakefulness 21 participants sum total 292 days. Functional linear modeling was used 24-h time-averaged circadian investigate effect...
The human facial skin microbiome is remarkably similar across all people sampled to date, dominated by facultative anaerobe Cutibacterium. origin of this genus unknown, with no close relatives currently described from samples primate skin. This apparent human-specific bacterial taxon could reflect the unique nature skin, which significantly more oily than that our closest relatives. However, previous studies have not primates. Here, we profiled zoo-housed chimpanzees (Pan troglodytes), and...
This study contributes to the sparse literature on infant skin microbiome in general, and virtually nonexistent a field setting. While research often addresses patterns at national scale, this influence of population-level factors, such as maternal socioeconomic status contact with caregivers, bacterial communities. approach strengthens our understanding how local variables microbiome, paves way for additional studies combine biological sample collection questionnaires adequately capture...
The skin harbors a dynamic community of microorganisms, where contact with humans, other animals and the environment can alter microbial communities. Most research on human microbiome features Western populations living in hygienic conditions, yet these have vastly different patterns environmental than majority people Earth, including those developing countries.We studied communities humans cattle (zebu) rural Madagascar to investigate how zebu ownership affects composition skin,...
Elevated blood pressure presents a global health threat, with rates of hypertension increasing in low and middle-income countries. Lifestyle changes may be an important driver these increases pressure. Hypertension is particularly prevalent African countries, though the majority studies have focused on mainland Africa. We collected demographic data from 513 adults living community rural Madagascar. used generalized linear mixed models to assess body mass index (BMI), age, sex, attributes...
The skin harbors diverse communities of microorganisms, and alterations to these can impact the effectiveness as a barrier infectious organisms or injury. As global availability adoption antibacterial products increases, it is important understand how affect microbial people living in rural areas developing countries, where risks infection injury often differ from urban populations developed countries. We investigated effect soap on Malagasy population that practices subsistence agriculture...
Abstract Introduction: Social interactions shape the infant microbiome by providing opportunities for caregivers to spread bacteria through physical contact. With most research focused on impact of maternal–infant contact gut microbiome, it is unclear how alloparents (i.e., other than parents) influence bacterial communities body sites that are frequently contacted during bouts caregiving, including skin. Methods: To begin understand allocare may diversity detailed questionnaire data...
The skin, as well its microbial communities, serves the primary interface between human body and surrounding environment. In order to implement skin microbiome into biology research, there is a need explore effects of different sample collection storage methodologies, including feasibility conducting studies in field settings.We collected 99 samples from nine infants living Veracruz, Mexico using dual-tipped "dry" swab on right armpit, palm, forehead "wet" (0.15 M NaCl 0.1% Tween 20) same...
Abstract Objectives The gut microbiome (GM) connects physical and social environments to infant health. Since the GM affects immune system development, there is interest in understanding how infants acquire microbes from mothers other household members. Materials Methods As a part of Cebu Longitudinal Health Nutrition Survey (CLHNS), we paired fecal samples (proxy for GM) collected living Metro Cebu, Philippines at 2 weeks ( N = 39) 6 months 36) with maternal interviews about prenatal...
Abstract A central goal of biological anthropology is connecting environmental variation to differences in host physiology, biology, health, and evolution. The microbiome represents a valuable pathway for studying how environments impacts health outcomes. While there are many resources learning about methods related sample collection, laboratory analyses, genetic sequencing, fewer dedicated helping researchers navigate the dense portfolio bioinformatics statistical approaches analyzing data....
Abstract Microbial exposures during infancy shape the development of microbiome, collection microbes living in and on body, which turn directs immune system training. Newborns acquire a substantial quantity birth throughout via exposure to physical social environment. Alterations early life microbial environments may give rise mismatches, where environmental, cultural, behavioral changes that outpace body’s adaptive responses can lead adverse health outcomes, particularly those related...
Breastfeeding supplies infant gut bacteria with human milk oligosaccharides (HMOs) as a nutrient source. HMO profiles are influenced by the FUT2 gene, which encodes an enzyme affecting fucosylation of sugars. 20 to 40% individuals have “non-secretor” polymorphism that inactivates resulting in variable proportions milk. This has engendered concerning, yet unfounded, perception non-secretor is “inferior.” To address this untested hypothesis, we re-analyzed two datasets previously showed...