A5021199761- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Gut microbiota and health
- Exercise and Physiological Responses
- Heme Oxygenase-1 and Carbon Monoxide
- Travel-related health issues
- Cancer, Hypoxia, and Metabolism
- Dermatology and Skin Diseases
- Pregnancy and preeclampsia studies
- Diet and metabolism studies
- Genetics and Physical Performance
- Muscle metabolism and nutrition
- Human-Animal Interaction Studies
- Thermal Regulation in Medicine
- Sleep and Wakefulness Research
- Adipose Tissue and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Birth, Development, and Health
- Circadian rhythm and melatonin
- Sleep and related disorders
University of California, San Diego
2020-2024
Duke University
2017-2018
Hypoxia-inducible factor pathway genes are linked to adaptation in both human and nonhuman highland species. EPAS1 , a notable target of hypoxia adaptation, is associated with relatively lower hemoglobin concentration Tibetans. We provide evidence for an association between adaptive variant (rs570553380) the same phenotype low hematocrit Andean highlanders. This Andean-specific missense present at modest frequency Andeans absent other populations vertebrate species except coelacanth....
We studied sleep in a rural population Madagascar to (i) characterize an equatorial small-scale agricultural without electricity, (ii) assess whether is linked noise levels dense population, and (iii) examine the effects of experimentally introduced artificial light on timing.Using actigraphy, sleep-wake patterns were analyzed for both daytime napping nighttime wakefulness 21 participants sum total 292 days. Functional linear modeling was used 24-h time-averaged circadian investigate effect...
The skin harbors a dynamic community of microorganisms, where contact with humans, other animals and the environment can alter microbial communities. Most research on human microbiome features Western populations living in hygienic conditions, yet these have vastly different patterns environmental than majority people Earth, including those developing countries.We studied communities humans cattle (zebu) rural Madagascar to investigate how zebu ownership affects composition skin,...
The skin harbors diverse communities of microorganisms, and alterations to these can impact the effectiveness as a barrier infectious organisms or injury. As global availability adoption antibacterial products increases, it is important understand how affect microbial people living in rural areas developing countries, where risks infection injury often differ from urban populations developed countries. We investigated effect soap on Malagasy population that practices subsistence agriculture...
We chose the "natural laboratory" provided by high-altitude native ethnic Tibetan women who had completed childbearing to examine hypothesis that multiple oxygen delivery traits were associated with lifetime reproductive success and genomic associations. Four hundred seventeen (417) aged 46 86 y residing at ≥3,500 m in Upper Mustang, Nepal, information on histories, sociocultural factors, physiological measurements, DNA samples for this observational cohort study. Simultaneously assessing...
Exposure to low-oxygen conditions (hypoxia), as encountered at high altitudes and in some pathological conditions, results the activation of various physiological stressors acclimatization hypoxia. Previous studies show that administration a novel probiotic (SLAB51; O2BOOSTER; Hecto, Seoul, South Korea) improves oxygen saturation severely hypoxemic COVID-19 patients healthy participants upon exposure simulated terrestrial hypobaric hypoxic. Whether SLAB51 impacts stress responses such...
Exposure to high altitude leads decreased oxygen saturation (SpO 2 ) and, in some individuals, the development of adverse outcomes such as acute high-altitude sickness. A further decrease availability during exercise at greater anaerobic metabolism and increased lactate production. Previous studies show that ingestion probiotic SLAB51 (O2BOOSTER; Hecto, Seoul, South Korea) improved SpO individuals exercising a hypobaric chamber (simulated 16,732 ft (~5100 m) above sea level) compared who did...
Hypobaric hypoxia imposes various challenges at high altitude that initiate differentphysiological responses as part of the acclimatization process. Current interventions foraccelerating and/or improving to are limited. Preliminarystudies multi-strain probiotic SLAB51 (O2booster; Hecto, Seoul, South Korea)have shown its potential improve oxygenation, a crucial component ofacclimatization, in clinical conditions hypoxemia. We hypothesized treatment withSLAB51 will lead improved measured by...
Populations living at high altitude have been subjected to the selective pressure of hypoxia due low atmospheric for hundreds generations. Adaptive genetic signals are apparent in genomes present-day populations, but links physiological changes and underlying mechanisms not completely understood. Our recent studies revealed that Tibetans residing intermediate (2200 m; 13,780 ft) lower hemoglobin concentration ([Hb]) elevated carbon monoxide (CO) relative other populations resident same...
Hypobaric hypoxia exerts a significant evolutionary pressure on highlanders who have resided at high altitude for thousands of years. This has resulted in signatures natural selection within native highlanders’ genomes, some which associate with adaptive physiological traits. Our recent analyses examined the overlap priori functional candidate genes and identified composite multiple signals test 40 Andean genomes. We ICAM1, encodes intercellular adhesion molecule 1 protein, as one top 10...
Populations living at high altitudes exhibit distinct cardiovascular and ventilatory responses to hypoxia, which may result from exposure the selective pressure of chronic hypoxia throughout hundreds generations altitude. Compared Andean highlanders some acclimatized lowlanders, many Tibetans show an increased hypoxic response (HVR) lower hemoglobin concentration ([Hb]). While effects menopause on [Hb] have been well studied, its HVR heart rate (HHRR) in Tibetan women residing altitude not...
Population living at high altitudes for hundreds of generations exhibit distinct respiratory and cardiovascular responses to hypoxia relative other populations. The extent these differences intermediate altitude is less understood could provide important insight into ancestry specific physiological in the absence hypoxia. We hypothesized that Tibetans (1300 m, 4327 ft) an increased hypoxic ventilatory response (HVR) elevated heart rate (HHR) compared Han Chinese examined same altitude. To...
People with high-altitude ancestry exhibit distinct cellular, respiratory, and cardiovascular adaptive phenotypes relative to individuals lowland ancestry. For example, Tibetans at high altitude higher ventilatory responses hypoxia Han Chinese comparable altitude. We hypothesize living intermediate maintain similar those measured levels of total hemoglobin ([Hb]), carboxyhemoglobin saturation (SpCO), methemoglobin (MetHb), as well the hypoxic heart rate acute (HVR HHR, respectively) under...