A5037239718- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Erythropoietin and Anemia Treatment
- Cancer, Hypoxia, and Metabolism
- Hemoglobinopathies and Related Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adipose Tissue and Metabolism
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
Universidad Peruana Cayetano Heredia
2014-2024
Hypoxia-inducible factor pathway genes are linked to adaptation in both human and nonhuman highland species. EPAS1 , a notable target of hypoxia adaptation, is associated with relatively lower hemoglobin concentration Tibetans. We provide evidence for an association between adaptive variant (rs570553380) the same phenotype low hematocrit Andean highlanders. This Andean-specific missense present at modest frequency Andeans absent other populations vertebrate species except coelacanth....
Corante, Noemí, Cecilia Anza-Ramírez, Rómulo Figueroa-Mujíca, José Luis Macarlupú, Gustavo Vizcardo-Galindo, Grzegorz Bilo, Gianfranco Parati, Jorge L. Gamboa, Fabiola León-Velarde, and Francisco C. Villafuerte. Excessive erythrocytosis cardiovascular risk in Andean highlanders. High Alt Med Biol. 19:221-231, 2018.-Cardiovascular diseases are the main cause of death worldwide. Life under high-altitude (HA) hypoxic conditions is believed to provide highlanders with a natural protection...
Excessive erythrocytosis (EE) is the hallmark of chronic mountain sickness (CMS), a prevalent syndrome in high-altitude Andean populations. Although hypoxemia represents its underlying stimulus, why some individuals develop EE despite having altitude-normal blood erythropoietin (Epo) concentration still unclear. A soluble form Epo receptor (sEpoR) has been identified human and competes directly for with membrane counterpart (mEpoR). Thus, reduced levels circulating sEpoR could lead to higher...
Excessive erythrocytosis (EE) is the main sign of chronic mountain sickness (CMS), a maladaptive clinical syndrome prevalent in Andean and other high-altitude populations worldwide. The pathophysiological mechanism EE still controversial, as physiological variability systemic respiratory, cardiovascular, hormonal responses to hypoxemia complicates identification underlying causes. Induced pluripotent stem cells derived from CMS highlanders showed increased expression genes relevant...
Excessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a highly prevalent syndrome in Andean highlanders. Low pulse O2 saturation (SpO2) during sleep and serum androgens have been suggested to contribute EE CMS patients. However, whether these factors significant impact on erythropoietin (Epo) system leading still unclear. We recently shown that morning soluble Epo receptor (sEpoR), an endogenous antagonist, decreased patients suggesting increased availability...
Andean highlanders are challenged by chronic hypoxia and many exhibit elevated hematocrit (Hct) blunted ventilation compared to other high-altitude populations. While Andeans develop Chronic Mountain Sickness (CMS) excessive erythrocytosis, Hct varies markedly within men women may be driven individual differences in ventilatory control and/or sleep events which exacerbate hypoxemia. To test this hypothesis, we quantified relationships between resting chemoreflexes, desaturation, breathing...
Excessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a maladaptive syndrome with significant prevalence in high‐altitude inhabitants. Although chronic hypoxemia represents its underlying stimulus, fundamental pathophysiological mechanism still debatable. Studies during sleep CMS patients consistently find lower average pulse O 2 saturation (SpO ) compared to healthy highlanders (HH). Although, whether accentuated has impact on Epo system that could explain...
The gene encoding interleukin‐6 (IL‐6) shows signals of evolutionary selection in Tibetans and Andeans could be a target convergent adaptation to high altitude. Furthermore, IL‐6 is elevated sea‐level residents upon acute high‐altitude exposure, involved both the inflammatory hypoxia‐response pathways via HIF‐1a NFκB regulation, plays role regulating hematopoiesis. We hypothesized that adapted populations have variants associated with reduced IL6 expression prevent chronic systemic...
Multiple adaptive phenotypes for high‐altitude and hypoxic stress have developed by distinct evolutionary trajectories in highland populations. For example, considerable variation is observed the ventilatory response (HVR) of Tibetans, while high altitude Andean populations show blunted responses low this trait. Evidence suggests that genetic background plays a major role these adaptations as native highlanders exhibit signals genomic regions containing genes related to response. In some...