A5071363472- Gastrointestinal motility and disorders
- Gut microbiota and health
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Microscopic Colitis
- Inflammatory Bowel Disease
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- Anesthesia and Sedative Agents
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Genomics, phytochemicals, and oxidative stress
- Esophageal and GI Pathology
- Congenital gastrointestinal and neural anomalies
- Abdominal vascular conditions and treatments
- Infectious Aortic and Vascular Conditions
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Diet and metabolism studies
- Aortic aneurysm repair treatments
- Probiotics and Fermented Foods
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
University of Vermont
2011-2023
Finch Therapeutics (United States)
2021-2023
Takeda (Japan)
2020
Clinical Science Institute
2020
University of Vermont Medical Center
2001-2018
Allen Hospital
2008
Columbia University
2003
Novartis (Canada)
2003
Tufts University
2003
Harvard University
2003
Switching ON resistance Clonal bacterial colonies will often grow dissimilar patches, similar to a tortoiseshell pattern. These differing phenotypes arise by reversible mechanisms called phase variation. Jiang et al. developed an algorithm survey genomes for invertible promoters that cause Inverted repeats signal the presence of these promoters, which can flip between and OFF states catalyzed phage integrase analogs invertases. Invertible linked antibiotic genes were widespread among...
Objective To generate real-world evidence for the epidemiology of gastroparesis in UK, we evaluated prevalence, incidence, patient characteristics and outcomes Clinical Practice Research Datalink (CPRD) database. Design This was a retrospective, cross-sectional study. Prevalence incidence were CPRD database, with linkage to Hospital Episodes Statistics Admitted Patient Care Office National mortality data. age sex standardised mid-2017 UK population estimates. Descriptive analyses...
Fecal microbiota transplantation (FMT) is a promising new strategy in the treatment of Inflammatory Bowel Disease, but long-term delivery systems are lacking. This randomized study was designed as safety and feasibility FMT subjects with mild to moderate UC using frozen, encapsulated oral (cFMT).Subjects were 1:1 receive induction by colonoscopy, followed 12 weeks daily administration frozen cFMT or sham therpay. Subjects for 36 longitudenal clinical assessments included multiple subjective...
Humans are inextricably linked to each other and our natural world, microorganisms lie at the nexus of those interactions. Microorganisms form genetically flexible, taxonomically diverse, biochemically rich communities, i.e., microbiomes that integral health development macroorganisms, societies, ecosystems.
The precise aetiology of achalasia is unknown although autoimmunity has been implicated and supported by several studies. We screened sera from patients with or gastro-oesophageal reflux disease (GORD) to test for circulating antimyenteric neuronal antibodies.Serum was obtained 45 individuals achalasia, 16 GORD, 22 normal controls. Serum used in immunohistochemistry label whole mount preparations ileum oesophagus the guinea pig mouse. Also, sections superior cervical dorsal root ganglia,...
AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent (pcSEMS) to plastic (PS) in patients treated for malignant, infrahilar biliary obstruction. METHODS:Multicenter prospective randomized clinical trial with treatment allocation a pcWallstent ® (SEMS) or 10 French PS.Palliative aged ≥ 18, malignant obstruction Karnofsky performance scale index > 60% from 6 participating North American university centers.Primary endpoint was time failure, secondary...
For fecal microbiota transplantation (FMT) to be successful in immune diseases like inflammatory bowel disease, it is assumed that therapeutic microbes and their beneficial functions interactions must colonize a recipient patient persist sufficient quantity for period of time produce clinical benefit. Few studies, however, have comprehensively profiled the colonization persistence transferred along with transfer microbial host system. Using 16S, metagenomic, immunoglobulin A (IgA)...
Changes in mucosal serotonin (5-HT) signaling have been detected a number of functional and inflammatory disorders the gastrointestinal (GI) tract. This study was undertaken to determine whether chronic constipation (CC) is associated with disordered 5-HT evaluate caused by opiate use causes such changes.Human rectal biopsy samples were obtained from healthy volunteers, individuals idiopathic CC, taking medication or without occurrence constipation. EC cells identified immunohistochemistry....
Subacute hepatitis and liver failure occurred in a 40-yr-old woman following 1-month course of treatment with the nonsteroidal anti-inflammatory drug bromfenac. Serologies for A, B, C were negative, as antinuclear antibodies ceruloplasmin. A transjugular biopsy demonstrated submassive hepatic necrosis. The clinical was complicated by encephalopathy, fluid retention, spontaneous bacterial peritonitis, prompting consideration transplantation. With supportive measures, jaundice retention...
OBJECTIVES: The aims of this study were to determine if there was a difference in procedure-related abdominal discomfort or willingness return for subsequent screening examinations between patients undergoing colonoscopy and those flexible sigmoidoscopy. METHODS: Two groups compared: referred sigmoidoscopy colonoscopy. All asymptomatic colorectal cancer. Four university-based gastroenterologists performed all procedures. Patients received conscious sedation but not A research nurse blinded...
BACKGROUND/OBJECTIVE: Partially covered self-expandable metal stents (SEMS) and polyethylene (PES) are both commonly used in the palliation of malignant biliary obstruction. Although SEMS significantly more expensive, they efficacious than PES. Accordingly, a cost-effectiveness analysis was performed. METHODS: A compared approach initial placement PES versus for study population. Patients with obstruction underwent an endoscopic retrograde cholangiopancreatography to insert stent. If...
Evaluating bacterial communities across different locations in the gut provides a greater insight than fecal samples alone and an additional metric by which to evaluate beneficial host-microbe interactions. Here, we show that 10% steamed broccoli sprouts diet protects mice from negative effects of dextran sodium sulfate-induced colitis, colitis erases biogeographic patterns gut, cecum is not likely be significant contributor colonic bacteria interest DSS mouse model ulcerative colitis. Mice...
To our knowledge, IL-10-KO mice have not previously been used to investigate the interactions of host, microbiota, and broccoli, broccoli sprouts, or bioactives in resolving symptoms CD. We showed that a diet containing 10% raw sprouts increased plasma concentration anti-inflammatory compound sulforaphane protected varying degrees against disease symptoms, including weight loss stagnation, fecal blood, diarrhea. Younger responded more strongly diet, further reducing as well gut bacterial...
Bile leak after cholecystectomy is well described, with the cystic duct remnant site of in majority cases. Endoscopic retrograde cholangiopancreatography (ERCP) biliary stent placement has a high success rate such When ERCP fails, options include surgery, and percutaneous endoscopic transcatheter occlusion bile leak. Here, we describe case persistent using N ‐butyl cyanoacrylate glue. A 51‐year‐old man had pain bilious drainage following laparoscopic cholecystectomy. The persisted for...