A5100375746- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune cells in cancer
- Psoriasis: Treatment and Pathogenesis
- Virus-based gene therapy research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- IL-33, ST2, and ILC Pathways
- Medicinal Plant Pharmacodynamics Research
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Medical Research and Treatments
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Cancer Cells and Metastasis
- Quinazolinone synthesis and applications
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Long-Term Effects of COVID-19
- Protein Tyrosine Phosphatases
- Dermatology and Skin Diseases
Union Hospital
2024-2025
Anhui Medical University
2022-2025
Shanghai Jiao Tong University
2016-2025
Shanghai First People's Hospital
2016-2025
Huazhong University of Science and Technology
2024-2025
Universität der Bundeswehr München
2019-2024
Universität Hamburg
2019-2024
University Medical Center Hamburg-Eppendorf
2021-2024
Nanjing University of Finance and Economics
2024
Jilin University
2024
The liver is one of the organs most commonly affected by metastasis. presence metastases has been reported to be responsible for an immunosuppressive microenvironment and diminished immunotherapy efficacy. Herein, we aimed investigate role IL-10 in metastasis determine how its modulation could affect efficacy vivo.
White adipose tissue (WAT) overgrowth in obesity is linked with increased aggressiveness of certain cancers. Adipose stromal cells (ASCs) can become mobilized from WAT, recruited by tumours and promote cancer progression. Mechanisms underlying ASC trafficking are unclear. Here we demonstrate that chemokines CXCL1 CXCL8 chemoattract signalling through their receptors, CXCR1 CXCR2, cell culture models. We further show obese patients prostate have epithelial expression. Concomitantly, observe...
Tumor microenvironment (TME) promotes immune suppression through recruiting and expanding suppressive cells such as regulatory T (Tregs) to facilitate cancer progression. In this study, we identify a novel CD39+ γδTreg in human colorectal (CRC). γδTregs are the predominant have more potent immunosuppressive activity than CD4+ or CD8+ Tregs via adenosine-mediated pathway but independent of TGF-β IL-10. They also secrete cytokines including IL-17A GM-CSF, which may chemoattract myeloid-derived...
Abstract Osteosarcoma (OS) is a primary malignant bone tumor that most commonly affects children, adolescents, and young adults. Here, we comprehensively analyze genomic, epigenomic transcriptomic data from 121 OS patients. Somatic mutations are diverse within the cohort, only TP53 significantly mutated. Through unsupervised integrative clustering of multi-omics data, classify into four subtypes with distinct molecular features clinical prognosis: (1) Immune activated (S-IA), (2) suppressed...
The pathogenesis of lung cancer, the most common is complex and unclear, leading to limited treatment options poor prognosis. To provide molecular insights into cancer development, we investigated function underlying mechanism SH2B3 in regulation cancer. We indicated was diminished while TGF-β1 elevated tissues cells. Low level correlated with prognosis patients. overexpression suppressed cell anoikis resistance, proliferation, migration, invasion, EMT, promoted those processes via reducing...
During metastasis, cancer cells invade, intravasate, enter the circulation, extravasate, and colonize target organs. Here, we examined role of interleukin (IL)-22 in metastasis. Immune cell-derived IL-22 acts on epithelial tissues, promoting regeneration healing upon tissue damage, but it is also associated with malignancy. Il22-deficient mice treated an antibody were protected from colon-cancer-derived liver lung metastasis formation, while overexpression promoted Mechanistically, acted...
Abstract Signal transducer and activator of transcription 3 (STAT3) has important roles in cancer aggressiveness been confirmed as an attractive target for therapy. In this study, we used a dual-luciferase assay to identify that pectolinarigenin inhibited STAT3 activity. Further studies showed constitutive interleukin-6-induced signaling, diminished the accumulation nucleus blocked DNA-binding activity osteosarcoma cells. Mechanism investigations indicated disturbed STAT3/DNA...
It has been reported that in patients with operable stage I non-small cell lung cancer (NSCLC), overall survival (OS) is better those who undergo hypofractionated stereotactic radiation therapy (HSRT) than surgery. However, the reason HSRT a OS not fully explored. Here, we analyzed reconstitution kinetics immune cells peripheral blood of NSCLC after HSRT. We found increased frequency total T cells, especially proportion CD8+ but decreased inhibitory Tregs. Intracellular staining showed HSRT,...
The objective of this research was to investigate the effects Lactobacillus acidophilus CICC 6074 S-layer protein on viability, adhesion, cell cycle, and apoptosis human colon cancer HT-29 cells explore their molecular mechanism tumor suppression. at doses 0, 25, 50, 100 mg/L significantly suppressed proliferation cells. exerts its cytotoxic activities against by arresting cycle in G1 phase through upregulating expression p53, p21, p16 downregulating CDK1 (cyclin-dependent kinases) cyclin B....
Osteosarcoma is one of the most common malignant bone tumors. However, treatment and clinical outcomes osteosarcoma have hardly changed over past three decades due to comprehensive heterogeneity higher rate mutation osteosarcoma. Recent studies shown that STAT3 has potential suppress proliferation metastasis In this study, a novel class 2-amino-3-cyanothiophene derivatives were designed synthesized inhibit by targeting STAT3. Representative compound 6f showed potent antiproliferative effects...
The effectiveness of neoadjuvant immune checkpoint inhibitor (ICI) therapy is confirmed in clinical trials; however, the patients suitable for receiving this remain unspecified. Previous studies have demonstrated that tumor microenvironment (TME) dominates immunotherapy; therefore, an effective TME classification strategy required. In study, five crucial immunophenotype-related molecules (WARS, UBE2L6, GZMB, BATF2, and LAG-3) are determined public gastric cancer (GC) datasets (n = 1426)...
Forced metastasis models, those in which the step of intravasation is bypassed, can be used to investigate mechanisms underlying and evaluate potential therapeutic targets. Here, we present a protocol for using three forced models lung liver generate within 3-4 weeks approximately 99% injected mice. We describe steps cancer cell preparation, mouse analgesia anesthesia; injecting through intrasplenic, intraportal, intravenous techniques; daily evaluation metastasis. For complete details on...
The standard therapy for locally unresectable advanced non-small cell lung cancer (NSCLC) is comprised of chemoradiotherapy (CRT) before immunotherapy (IO) consolidation. However, how to predict treatment outcomes and recognize patients that will benefit from IO remain unclear. This study aimed identify prognostic biomarkers by integrating computed tomography (CT)-based radiomics genomics. Specifically, our research involved 165 suffering Stage III NSCLC. Cohort 1 (IO following CRT) was...
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we identify subgroup of OS methylthioadenosine phosphorylase (MTAP) deletion, which contributes ICT resistance, leading "cold" microenvironment. MTAP-deleted relies on methionine metabolism is sensitive intervention, achieved through either dietary restriction or inhibition adenosyltransferase 2a (MAT2A), key...
Leukemia inhibitory factor receptor (LIFR) has been documented as a cancer promoter and to be present at high levels in various types of tumor tissues. In our search for molecules prognostic colorectal (CRC), we found LIFR CRC tissue samples. Further analyses revealed that was indeed patient survival, associated with size, lymphatic metastasis stages. promote growth, angiogenesis both vitro vivo. High facilitated proliferation migration endothelial cells, resulting an increase angiogenic...
Osteosarcoma (OS) is the most common primary bone malignancy in adolescents. One major obstacle for current OS treatment drug-resistance. Raddeanin A (RA), an oleanane-type triterpenoid saponin, exerts anti-tumor effects several tumor models, but effect of RA human drug-resistant remained to be elucidated. In present study, we investigated both drug-sensitive and cells its underlying mechanism. inhibited cell proliferation colony formation induced apoptotic death a dose-dependent manner...