A5017140872- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Radiopharmaceutical Chemistry and Applications
- Boron Compounds in Chemistry
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Brain Metastases and Treatment
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Lung Cancer Research Studies
- Cancer, Lipids, and Metabolism
- Boron and Carbon Nanomaterials Research
- RNA Interference and Gene Delivery
- Gut microbiota and health
- Esophageal Cancer Research and Treatment
- Advanced Radiotherapy Techniques
- Gallbladder and Bile Duct Disorders
Zhejiang University
2016-2025
Beijing Anzhen Hospital
2025
Capital Medical University
2025
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
Second Affiliated Hospital of Zhejiang University
2016-2025
Zhejiang Cancer Hospital
2021-2024
Ministry of Education of the People's Republic of China
2016-2024
Southwest Medical University
2023
Huzhou Central Hospital
2023
Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). In this phase 3 study (ClinicalTrial.gov: NCT03829969), 514 patients with treatment-naïve ESCC were randomized (1:1) to receive toripalimab or placebo in combination paclitaxel plus cisplatin (TP) every weeks up 6 cycles, followed by maintenance. At prespecified final analysis of progression-free survival (PFS), a significant improvement PFS observed arm over (hazard ratio...
Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity atherosclerosis. We test, whether augments angiotensin II (Ang II)-induced vasoconstriction hence promotes Ang II-induced hypertension. Plasma levels were indeed elevated hypertensive patients, thus potential pathways which mediates these effects explored. (400...
Experience in clinical practice and research systems pharmacology suggested the limitations of current one-drug-one-target paradigm new drug discovery. Single-target drugs may not always produce desired physiological effects on entire biological system, even if they have successfully regulated activities their designated targets. On other hand, multicomponent therapy, which two or more agents simultaneously interact with multiple targets, has attracted growing attention. Many combinations...
Currently, the limited penetration of nanoparticles remains a major challenge for antitumor nanomedicine to penetrate into tumor tissues. Herein, we propose size-shrinkable drug delivery system based on polysaccharide-modified dendrimer with microenvironment responsiveness first time our knowledge, which was formed by conjugating terminal glucose hyaluronic acid (HA) superficial amidogen poly(amidoamine) (PAMAM), using matrix metalloproteinase-2 (MMP-2)-cleavable peptide (PLGLAG) via click...
Glioblastoma is the most common brain primary malignant tumor with highest mortality. Boron neutron capture therapy (BNCT) can efficiently kill cancer cells on cellular scale, high accuracy, short course and low side-effects, which regarded as promising for tumors like glioma. As keypoint of BNCT, all boron delivery agents currently in clinical use are beset by insufficient uptake, especially nucleus, limits application BNCT. In this study, nuclear targeting achieved DOX-CB, consisting...
To identify subgroups of patients with early-stage (pT1-2N0M0) oral tongue squamous cell carcinoma (OTSCC) who may benefit from postoperative radiotherapy (PORT).
There is currently no worldwide consensus for the management of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). We evaluated efficacy stereotactic body radiotherapy (SBRT) as initial treatment HCC extensive PVTT based on a relatively large number patients.In our multidisciplinary approach patients hepatobiliary tumors, SBRT recommended unresectable or those contraindication transarterial chemoembolization (TACE). The aim to shrink and preserve adequate venous flow,...
Multidrug resistance (MDR) is the major obstacle for chemotherapy. In a previous study, we have successfully synthesized novel doxorubicin (DOX) derivative modified by triphenylphosphonium (TPP) to realize mitochondrial delivery of DOX and showed potential this compound overcome in MDA-MB-435/DOX cells.(1) To introduce specificity DOX-TPP cancer cells, here report on conjugation hyaluronic acid (HA) hydrazone bond with adipic dihydrazide (ADH) as acid-responsive linker, producing...
The expression of EGFR, HER2 and HER3 receptors were analyzed in immunohistochemical preparations from primary esophageal tumours corresponding lymph node metastases. goal was to evaluate whether any these are suitable as targets for radionuclide based imaging therapy. receptor expressions evaluated parallel samples, tumour metastasis, each patient (n=51). majority the cases squamous cell carcinomas, ESCC (n=40). HercepTest scoring used analysis both EGFR (0, 1+, 2+ or 3+). only negative,...
Lung cancer is the leading cause of cancer-related death in United States, and metastatic behavior largely responsible for this mortality. Mutations multiple 'driver' oncogenes tumor suppressors are known to contribute lung tumorigenesis some cases represent therapeutic targets. Leucine Zipper Transcription Factor-like 1 (LZTFL1) located chromosome region 3p21.3 where allelic loss genetic alterations occur early frequently cancers. Previously, we found that LZTFL1 downregulated epithelial...
It has been reported that in patients with operable stage I non-small cell lung cancer (NSCLC), overall survival (OS) is better those who undergo hypofractionated stereotactic radiation therapy (HSRT) than surgery. However, the reason HSRT a OS not fully explored. Here, we analyzed reconstitution kinetics immune cells peripheral blood of NSCLC after HSRT. We found increased frequency total T cells, especially proportion CD8+ but decreased inhibitory Tregs. Intracellular staining showed HSRT,...
Photodynamic therapy (PDT) is a promising treatment modality for the management of malignant diseases. However, general acceptance PDT has been hampered due to limited tissue penetration light and unavailability suitable photosensitizers (PSs). The innovative combination conventional radiotherapy (RT) with might reduce unacceptable normal toxicity while maintaining desired tumor suppression effect. There have number attempts examine interaction RT; however, previous results presented are...