A5032775193- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Acute Kidney Injury Research
- Erythrocyte Function and Pathophysiology
- Ferroptosis and cancer prognosis
- Renal Transplantation Outcomes and Treatments
- Diet and metabolism studies
- Gut microbiota and health
- Immune Response and Inflammation
- Biochemical Acid Research Studies
- Hydrogen's biological and therapeutic effects
- Colorectal and Anal Carcinomas
- Parathyroid Disorders and Treatments
- Hemoglobin structure and function
- Coenzyme Q10 studies and effects
- Cancer, Lipids, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Dietary Effects on Health
- Tryptophan and brain disorders
- Thermoregulation and physiological responses
- Renal Diseases and Glomerulopathies
- Immune cells in cancer
- Ectopic Pregnancy Diagnosis and Management
- Neurological Complications and Syndromes
- Folate and B Vitamins Research
Sun Yat-sen University
2017-2024
Charité - Universitätsmedizin Berlin
2022-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2020-2024
Humboldt-Universität zu Berlin
2022-2024
Freie Universität Berlin
2022-2024
The First Affiliated Hospital, Sun Yat-sen University
2017-2022
Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity atherosclerosis. We test, whether augments angiotensin II (Ang II)-induced vasoconstriction hence promotes Ang II-induced hypertension. Plasma levels were indeed elevated hypertensive patients, thus potential pathways which mediates these effects explored. (400...
Abstract Ferroptosis is caused by lipid peroxidation and iron accumulation can cause cell death. Abnormally expressed transporters are involved in ferroptosis a variety of diseases. ZRT/IRT-like protein 14 (ZIP14) transport that mediate cellular uptake iron, zinc, manganese. Herein, we have tested the hypothesis divalent metal transporter ZIP14 initiation diabetic nephropathy (DN). DN was induced 8-week-old male rats streptozotocin before analysis degree renal tubular injury. In addition, an...
Abstract Aims Hypertension (HTN) can lead to heart and kidney damage. The gut microbiota has been linked HTN, although it is difficult estimate its significance due the variety of other features known influence HTN. In present study, we used germ-free (GF) colonized (COL) littermate mice quantify impact microbial colonization on organ damage in Methods results 4-week-old male GF C57BL/6J littermates were randomized remain or receive colonization. HTN was induced by subcutaneous infusion with...
Background: To provide tacrolimus is first-line treatment after liver and kidney transplantation. However, hypertension nephrotoxicity are common side effects that limit its use. Although tacrolimus-related well known, the underlying mechanisms not. Here, we test whether tacrolimus-induced involves RhoA (Ras homolog family member A)/ROCK (Rho-associated protein kinase) pathway in male C57Bl/6 mice. methods: Intra-arterial blood pressure was measured under anesthesia. The reactivity of renal...
BACKGROUND: Acute hyperglycemia is a risk factor for developing acute kidney injury and poor renal outcome in critically ill patients, whereby the role of vasculature remains unclear. We hypothesize that hyperglycemia-associated hyperosmolarity facilitates vasodilation through Piezo1-mediated eNOS (endothelial NO synthase) activation. METHODS: Vasoreactivity was analyzed using wire myography isolated mouse mesenteric arteries interlobar, microvascular perfusion afferent arterioles efferent...
Cervical cancer is the fourth most common malignant tumor in women worldwide. The persistent infection of high-risk Human Papillomavirus (hrHPV) considered to be primary cause this disease. As an innate immune receptor, nucleotide-binding oligomerization domain protein-1 (NOD1) recognizes pathogen-associated molecular pattern (PAMP), subsequently initiating responses. NOD1 also involved apoptotic signaling pathway and mutates many cells. In study, we revealed that expression decreased during...
Acute kidney injury (AKI) causes multiple organ dysfunction. Here, we identify a possible mechanism that can drive brain vessel after AKI. We induced 30-minute bilateral renal ischemia-reperfusion in C57Bl/6 mice and isolated microvessels macrovessels 24 hours or 1 week later to test their responses vasoconstrictors found AKI vessels were sensitized Ang II (angiotensin II). Upregulation of FGF2 (fibroblast growth factor 2) FGFBP1 (FGF binding protein 1) expression both serum tissue suggested...
Post-ischemic acute kidney injury and disease (AKI/AKD) involve tubular necrosis irreversible nephron loss. Mononuclear phagocytes including conventional dendritic cells (cDCs) are present during different phases of repair, but the functional contribution this subset remains controversial. Transcription factor interferon regulatory 8 (IRF8) is required for development type I (cDC1s) lineage helps to define distinct cDC1 subsets. We identified one among mononuclear phagocyte subsets according...
In patients with renal disease, high serum phosphate shows a relationship cardiovascular risk. We speculate that (HP) impairs arterial vasodilation via the endothelium and explore potential underlying mechanisms. Isolated vessel relaxation, endothelial function, glomerular filtration rate (GFR), oxidative stress status protein expression were assessed in HP diet mice. Mitochondrial function HP-treated human umbilical vein cells (HUVECs). High (1.3%) for 12 weeks impaired...
In addition to liquid-based cytology (LBC) and HR HPV testing, p16/ki-67 dual-staining is another method for cervical cancer screening. The combination of any two methods can improve the accuracy screening, but some lesions are still missed or misdiagnosed. this retrospective study, significance LBC, testing especially in lesion screening was evaluated with reference histological diagnosis. At same time, we tried explore value combined LBC (triple detection) improving diagnostic specificity...
Abstract Objectives To evaluate the diagnostic values of urine liquid‐based cytology (LBC), fluorescence in situ hybridization (FISH), and p16/Ki‐67 dual immunostaining detection upper tract urothelial carcinomas (UTUCs). Methods Sixty‐one patients with UTUCs were retrospectively analyzed. All diagnosed both by FISH, histologically confirmed as UTUCs. Thirty‐two had been stained labeling. Results The sensitivities for low‐grade (LGUTUCs) high‐grade (HGUTUCs) 33.3% 67.4% LBC, 60% 69.6% 12.5%...
jabbrv-ltwa-all.ldf jabbrv-ltwa-en.ldf Long-term use of the immunosuppressant tacrolimus (Tac) is limited due to its nephrotoxic, hepatotoxic and diabetogenic effects. Up 33.6% solid organ transplantation patients receiving Tac treatment develop hyperglycemia; however, underlying mechanisms remain poorly elucidated. Here, using a mouse model Tac-induced hyperglycemia, we found that body-weight loss, hypoinsulinemia, glucose intolerance insulin resistance were improved by renin-angiotensin...
Journal of the American Society Nephrology 34(11S):p 497, November 2023. | DOI: 10.1681/ASN.20233411S1497a
The incidence of infertility is increasing, more than 30% them having related abnormal tubal patency. Four-dimensional (4D) hysterosalpingo-contrast sonography (HyCoSy) overcomes the shortcomings 3D HyCoSy in diagnosis patency, showing high specificity and accuracy. In addition, 4D discards iodine allergy X-ray radiation possesses easy-operating, contributing to good acceptance clinical practice. However, there no research explore imaging standards possibility natural pregnancy after HyCoSy....
Background: Acute hyperglycemia (HG) is a risk factor for developing acute kidney injury and poor renal outcome in critically ill patients. The role of vasculature this context not clear. We hypothesize that HG-associated hyperosmolarity facilitates vasodilation through Piezo1-mediated eNOS activation. Methods: Vasoreactivity isolated mouse mesenteric (MA) interlobar (ILA) arteries were analyzed using wire myography afferent (AA) efferent (EA) arterioles, vasa recta (VR) microvascular...
Abstract Background and Aims Post-ischemic acute tubular necrosis is a common cause of kidney disease (AKD) subsequent chronic disease. In AKD, mononuclear phagocytes (MPCs) including conventional dendritic cells (cDCs) are present during the different phases injury, repair regeneration. The contribution cDCs to AKD still poorly understood. Hence, we hypothesized that transcription factor interferon regulatory 8 (IRF8)-specific regulate immune response in AKD. Method was induced by...