A5071194180- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Cardiovascular Effects of Exercise
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Photoreceptor and optogenetics research
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Neural dynamics and brain function
- Epilepsy research and treatment
- Sports injuries and prevention
- ECG Monitoring and Analysis
- Cardiac Health and Mental Health
- Cardiomyopathy and Myosin Studies
- Health Systems, Economic Evaluations, Quality of Life
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Cardiac Valve Diseases and Treatments
Indiana University – Purdue University Indianapolis
2016-2025
Indiana University School of Medicine
2015-2025
Indiana University Indianapolis
2013-2024
University of Indianapolis
2012-2024
Royal North Shore Hospital
2024
Eskenazi Health Foundation
2023-2024
Eskenazi Health
2023-2024
American College of Cardiology
2014-2024
University of Pecs
2024
Széchenyi István University
2024
Ryanodine receptors have recently been shown to be the Ca2+ release channels of sarcoplasmic reticulum in both cardiac muscle and skeletal muscle. Several regulatory sites are postulated exist on these receptors, but date, none definitively identified. In work described here, we localize one by showing that isoform ryanodine receptor is a preferred substrate for multifunctional Ca2+/calmodulin-dependent protein kinase (CaM kinase). Phosphorylation CaM occurs at single site encompassing...
Background— Identifying hospitalized patients at risk for QT interval prolongation could lead to interventions reduce the of torsades de pointes. Our objective was develop and validate a score in patients. Methods Results— In this study, single tertiary care institution, consecutive (n=900) admitted cardiac units comprised development group. The then applied 300 additional validation Corrected (QT c ) (defined as >500 ms or an increase >60 from baseline) occurred 274 (30.4%) 90 (30.0%)...
<h3>Importance</h3> Myocarditis is a leading cause of sudden death in competitive athletes. Myocardial inflammation known to occur with SARS-CoV-2. Different screening approaches for detection myocarditis have been reported. The Big Ten Conference requires comprehensive cardiac testing including magnetic resonance (CMR) imaging all athletes COVID-19, allowing comparison approaches. <h3>Objective</h3> To determine the prevalence COVID-19 and compare strategies safe return play. <h3>Design,...
To ensure that guidelines reflect current knowledge, available treatment options, and optimum medical care, existing clinical practice guideline recommendations are modified new added in response to data, medications or devices. keep pace with evolving evidence, the American College of Cardiology (ACC)/American Heart Association (AHA) Task Force on Clinical Practice Guidelines ("Task Force") has issued this focused update revise basis recently published data. This is not based a complete...
Two guidelines from the American College of Cardiology (ACC), Heart Association (AHA), and collaborating societies address risk aortic dissection in patients with bicuspid valves severe enlargement: “2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for Diagnosis Management Patients With Thoracic Aortic Disease” (Circulation. 2010;121:e266–e369) “2014 AHA/ACC Guideline Valvular 2014;129:e521–e643). However, 2 differ regard to recommended threshold root or ascending dilatation that...
Fast neuronal network oscillations in the gamma range (∼30–90 Hz) have been implicated complex brain functions such as sensory processing, memory formation and, perhaps, consciousness, and appear to be exceptionally vulnerable various pathologies. However, both energy demand mitochondrial performance underlying are unknown. We investigated fundamental relationship between acetylcholine-induced oscillations, gene expression oxidative metabolism hippocampal slice preparations of mouse rat by...