A5089760217- Parathyroid Disorders and Treatments
- Vitamin D Research Studies
- Thyroid and Parathyroid Surgery
- Bone health and osteoporosis research
- Bariatric Surgery and Outcomes
- Thyroid Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Diabetes and associated disorders
- Diet and metabolism studies
- Vitamin C and Antioxidants Research
- Psoriasis: Treatment and Pathogenesis
- Prenatal Screening and Diagnostics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Medical Imaging and Pathology Studies
- Multiple Sclerosis Research Studies
- Rheumatoid Arthritis Research and Therapies
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Acute Lymphoblastic Leukemia research
- Alkaline Phosphatase Research Studies
- Eating Disorders and Behaviors
- Ubiquitin and proteasome pathways
- Magnesium in Health and Disease
- Fungal Infections and Studies
- Bone health and treatments
Massachusetts General Hospital
2015-2025
Harvard University
2012-2024
Boston Children's Hospital
2024
Endocrine Society
2009-2017
Stanford University
2011
University of Salford
2006
University of Manchester
1987-2006
Howard Hughes Medical Institute
2001
Icahn School of Medicine at Mount Sinai
1997-1998
University of Alberta
1998
Despite tremendous interest in hypoparathyroidism, large cohort studies describing typical treatment patterns, laboratory parameters, and rates of complications are lacking.Our objective was to characterize the course disease a hypoparathyroid patients.We conducted chart review patients with permanent hypoparathyroidism identified via clinical patient data registry. Patients were seen at Boston tertiary-care hospital system between 1988 2009.We 120 patients. Diagnosis confirmed by documented...
<h3>Importance</h3> Myocarditis is a leading cause of sudden death in competitive athletes. Myocardial inflammation known to occur with SARS-CoV-2. Different screening approaches for detection myocarditis have been reported. The Big Ten Conference requires comprehensive cardiac testing including magnetic resonance (CMR) imaging all athletes COVID-19, allowing comparison approaches. <h3>Objective</h3> To determine the prevalence COVID-19 and compare strategies safe return play. <h3>Design,...
Abstract Background Numerous studies demonstrate associations between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and a variety common disorders, including musculoskeletal, metabolic, cardiovascular, malignant, autoimmune, infectious diseases. Although causal link 25(OH)D many disorders has not been clearly established, these have led to widespread supplementation with vitamin increased laboratory testing for in the general population. The benefit-risk ratio this increase use is...
Apolipoprotein B (apoB) is the major protein component of atherogenic lipoproteins hepatic origin. In HepG2 cells, standard cell culture model human lipoprotein metabolism, there a limited availability core lipids in endoplasmic reticulum for association with nascent apoB. Under these conditions, apoB partially translocated, interacts cytosolic Hsp70, and undergoes rapid degradation. We show that increasing expression Hsp70 cells promotes addition, polyubiquitinated its degradation both...
When lipid synthesis is limited in HepG2 cells, apoprotein B100 (apoB100) not secreted but rapidly degraded by the ubiquitin-proteasome pathway. To investigate apoB100 biosynthesis and secretion further, physical functional states of destined for either degradation or lipoprotein assembly were studied under conditions which synthesis, proteasomal activity, microsomal triglyceride transfer protein (MTP) lipid-transfer activity varied. Cells pretreated with a inhibitor (which remained cells...
One hundred and eighty-two liver biopsies were performed over a 10-year period on patients receiving long-term, low-dose, once weekly oral methotrexate (MTX) for severe psoriasis. Forty-nine had two or more during continued treatment formed the study population our analysis. The first last compared to determine progression of any histological abnormalities. Liver assessed without knowledge MTX dose allocated one five groups according severity These defined as: (1) normal; (2) steatosis...
The diagnosis of hypoglycemia and the use diazoxide have risen in last decade. Diazoxide is only Food Drug Agency-approved pharmacologic treatment for neonatal caused by hyperinsulinism (HI). Recent publications highlighted that has serious adverse effects (AEs) such as pulmonary hypertension (2-3%) neutropenia (15%). Despite its increasing use, there little information regarding dosing and/or monitoring AEs.We convened a working group pediatric endocrinologists who were members Therapeutics...
Skeletal fragility is a significant complication of type 1 diabetes (T1D), with an increased risk fracture observed starting in childhood. Altered bone accrual and microarchitectural development during the critical peripubertal years may contribute to this fragility.To evaluate differences skeletal microarchitecture between girls T1D controls assess factors associated these differences.Cross-sectional comparison.Girls ages 10-16 years, 62 61 controls.Areal mineral density (BMD) measured by...
This study was designed to establish whether measurement of a serological marker fibrosis might reduce the need for liver biopsy in psoriatic patients receiving methotrexate (MTX). Levels type III procollagen aminopeptide (PIIINP-O and PIIINP-B) laminin P1 (LamP1-B) were measured 147 serum samples taken at time 87 long-term MTX treatment severe psoriasis. Biopsies classified as: (1) normal, (2) steatosis, (3) inflammation, (4) fibrosis, or (5) cirrhosis. Groups 3-5 considered show clinically...
The serum level of the aminoterminal peptide type III procollagen (P3NP) was measured in 51 psoriatic patients on long-term, once weekly, low-dose methotrexate and a control group with extensive psoriasis who had never systemic treatment. Serum P3NP levels were normal all patients, but elevated majority methotrexate-treated even those or non-specific liver histology. Although highest values found groups fibrosis cirrhosis, isolated measurements did not discriminate between individuals...