A5041802535- Ovarian function and disorders
- Hypothalamic control of reproductive hormones
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Growth Hormone and Insulin-like Growth Factors
- Adipose Tissue and Metabolism
- Adrenal Hormones and Disorders
- Menstrual Health and Disorders
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Disease and Adiposity
- Vitamin D Research Studies
- Ovarian cancer diagnosis and treatment
- Pituitary Gland Disorders and Treatments
- Thyroid Disorders and Treatments
- Estrogen and related hormone effects
- Plant Reproductive Biology
- Neuroendocrine regulation and behavior
- Menopause: Health Impacts and Treatments
- Reproductive Physiology in Livestock
- Sperm and Testicular Function
- Hormonal Regulation and Hypertension
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Vitamin C and Antioxidants Research
University of Virginia
2014-2024
West Virginia University
2024
University of Virginia Health System
2006-2021
Washington University in St. Louis
2019
San Antonio Uniformed Services Health Education Consortium
2019
Eastern Virginia Medical School
2019
Brown University
2019
Indiana University
2019
Indiana University School of Medicine
2019
University of Maryland, Baltimore
2017
Abstract Background Numerous studies demonstrate associations between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and a variety common disorders, including musculoskeletal, metabolic, cardiovascular, malignant, autoimmune, infectious diseases. Although causal link 25(OH)D many disorders has not been clearly established, these have led to widespread supplementation with vitamin increased laboratory testing for in the general population. The benefit-risk ratio this increase use is...
Context: Peripubertal obesity is associated with abnormal sex steroid concentrations, but the timing of onset and degree these abnormalities remain unclear. Objective: The objective study was to assess hyperandrogenemia across puberty in obese girls overnight changes Tanner stage 1–3 girls. Design: This a cross-sectional analysis. Setting: conducted at general clinical research centers. Subjects: Thirty normal-weight (body mass index for age < 85%) 74 ≥ 95%) peripubertal Intervention: Blood...
Adolescent hyperandrogenemia is considered a forerunner of adult polycystic ovary syndrome, but its etiology remains uncertain.Our objective was to explore the hypothesis that peripubertal obesity associated with hyperandrogenemia.We performed cross-sectional analysis data obtained at General Clinical Research Centers.Subjects were 41 obese [body mass index (BMI) for age, >or=95%] and 35 normal-weight (BMI <95%) girls.We used pooled blood samples (approximately 0500-0700 h; n = 64) while...
Compared with normal women, adults polycystic ovarian syndrome (PCOS) require higher progesterone (P) concentrations to inhibit GnRH (LH) pulse frequency, which contributes persistently rapid pulses and elevated LH levels in PCOS. To explore the origin of this abnormality, we assessed hypothalamic sensitivity P feedback nine controls 11 hyperandrogenemic (HA) adolescents. Subjects first underwent frequent blood sampling for h assess baseline frequency. Thereafter, oral estradiol micronized...
Context: Adult women with polycystic ovary syndrome (PCOS) have decreased GnRH pulse generator sensitivity to progesterone (P)-mediated slowing. This defect is androgen mediated because it reversed receptor blockade. Adolescent hyperandrogenism often precedes PCOS.
Abstract Context: Peripubertal obesity (body mass index-for-age ≥ 95%) in girls is associated with hyperandrogenemia. LH likely contributes to this relationship, but overnight secretion obese poorly characterized. Objective: The aim of the study was evaluate pulse characteristics throughout pubertal maturation. Design: We conducted a cross-sectional analysis. Setting: performed general clinical research center. Participants: Eight nonobese and five Tanner 1–2 participated, as well 32 12 3–5...
Abstract A long-held precept is that vitamin D supplementation primarily, if not exclusively, benefits individuals with low circulating 25-hydroxyvitamin (25[OH]D) concentrations at baseline. However, the most appropriate 25(OH)D threshold to distinguish unacceptably vs reliably adequate remains controversial. Such proposals have largely been based on observational studies, which provide less robust evidence compared randomized clinical trials (RCTs). Since Endocrine Society's first...
Abstract Vitamin D plays a critical role in many physiological functions, including calcium metabolism and musculoskeletal health. This commentary aims to explore the intricate relationships among skin complexion, race, 25-hydroxyvitamin (25[OH]D) levels, focusing on challenges Endocrine Society encountered during clinical practice guideline development. Given that increased melanin content reduces 25(OH)D production response UV light, development panel addressed potential for screening...
The luteal-follicular transition is characterized by decreasing plasma levels of E2, progesterone (P), and inhibin A, with concomitant increases in FSH LH levels. (and inference GnRH) pulse frequency from 1 every 3–4 h during the luteal phase to approximately pulse/h at midcycle surge. To examine regulation GnRH frequency, we gave 10 normally cycling women transdermal E2 oral P produce midluteal [364 ± 65.0 pmol/liter (99 18 pg/ml) 29.7 6.8 nmol/liter (9.3 2.1 ng/ml), respectively] for d...
Obesity in peripubertal girls is associated with hyperandrogenemia (HA), which can represent a forerunner of polycystic ovary syndrome (PCOS). However, not all obese demonstrate HA, and determinants HA remain unclear. We hypothesized that insulin luteinizing hormone (LH) are independent predictors free testosterone (T) concentration girls. To assess this further, fasting morning blood samples were collected from 92 (BMI-for-age percentile ≥95) various stages puberty. A multivariate...
Studies have associated obesity with peri-pubertal hyperandrogenemia. However, these studies were performed in academic centers and could been influenced by selection bias.
Doege-Potter syndrome is a paraneoplastic characterized by non-islet cell tumor hypoglycemia secondary to solitary fibrous tumor. This causes the secretion of prohormone form insulin-like growth factor II. We describe diagnosis and management use transarterial chemoembolization in patient with malignant extrapleural tumor.Our was 64-year-old Caucasian woman who initially presented urinary incontinence found have 14.5×9.0×9.0cm retroperitoneal compressing her bladder. Her surgically resected...