A5060198403- Bone health and osteoporosis research
- Parathyroid Disorders and Treatments
- Bone health and treatments
- Genetic Syndromes and Imprinting
- Bone and Joint Diseases
- Vitamin D Research Studies
- Pancreatic and Hepatic Oncology Research
- Metabolism, Diabetes, and Cancer
- Bone fractures and treatments
- Medical Imaging and Pathology Studies
- Medical Imaging Techniques and Applications
- Bone Metabolism and Diseases
- Thyroid and Parathyroid Surgery
- Hip and Femur Fractures
- Vitamin C and Antioxidants Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Alkaline Phosphatase Research Studies
- Orthopaedic implants and arthroplasty
- Diabetes and associated disorders
- Renal and related cancers
- Growth Hormone and Insulin-like Growth Factors
- Epigenetics and DNA Methylation
Henry Ford Health System
2016-2025
Henry Ford Hospital
2016-2025
Wayne State University
2003-2024
Henry Ford Health + Michigan State University Health Sciences
2024
Michigan State University
2023-2024
Ford Motor Company (United States)
2014-2023
Detroit R&D (United States)
2014-2020
Woodward (United States)
2020
GTx (United States)
2014
Abstract Background Numerous studies demonstrate associations between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and a variety common disorders, including musculoskeletal, metabolic, cardiovascular, malignant, autoimmune, infectious diseases. Although causal link 25(OH)D many disorders has not been clearly established, these have led to widespread supplementation with vitamin increased laboratory testing for in the general population. The benefit-risk ratio this increase use is...
Abstract We developed a novel immunoradiometric assay (IRMA; whole parathyroid hormone [PTH] IRMA) for PTH, which specifically measures biologically active PTH(1–84). The is based on solid phase coated with anti-PTH(39–84) antibody, tracer of125I-labeled antibody unique specificity to the first N-terminal amino acid of PTH(1–84), and calibrators diluted synthetic In contrast Nichols intact PTH IRMA, this new does not detect PTH(7–84) fragments only detects one immunoreactive peak in...
Several studies define optimal serum 25-hydroxyvitamin D (25-OHD) levels based on PTH level reaching an asymptote. However, results differ widely, ranging from 25-OHD of 12-44 ng/ml: many are constrained by small sample size.The objective the study was to determine relationship between and age in a very large reference laboratory database.This detailed cross-sectional analysis 312,962 paired measured July 2010 June 2011.Median proportion patients (PTH > 65 pg/ml), 63 successive frequency...
Purpose Accurate preoperative localization of parathyroid lesion(s) is crucial for successful surgical management primary hyperparathyroidism (PHPT). This study was conducted to compare the effectiveness ultrasonography (USG) neck, 99m Tc-sestamibi (MIBI) imaging with or without SPECT/CT, and 18 F-fluorocholine (FCH) PET/CT in lesions patients PHPT. Methods Fifty-four consecutive PHPT were included this prospective who underwent using 3 diagnostic modalities followed by surgery. The...
ABSTRACT There has been renewed interest of late in the role modeling-based formation (MBF) during osteoporosis therapy. Here we describe early effects an established anabolic (teriparatide) versus antiresorptive (denosumab) agent on remodeling-based (RBF), MBF, and overflow MBF (oMBF) human transiliac bone biopsies. Postmenopausal women with received subcutaneous teriparatide (n = 33, 20 μg/d) or denosumab 36, 60 mg once/6 months), open-label for 6 months at 7 US Canadian sites. Subjects...
With the widespread use of measurement bone mineral density to detect, diagnose, and monitor therapy in management osteoporosis, histomorphometry has largely been relegated research settings academic pursuits. However, cannot distinguish between osteoporosis other metabolic disorders such as different types osteomalacia, osteitis fibrosa, renal osteodystrophy, hypophosphatasia, Paget's disease bone. Furthermore, test tell us anything about microarchitecture bone, tissue level dynamics,...
ABSTRACT Historically, rickets and osteomalacia have been synonymous with vitamin D deficiency dating back to the 17th century. The term osteomalacia, which literally means soft bone, was traditionally applied characteristic radiologically or histologically documented skeletal disease not just clinical biochemical abnormalities. Osteomalacia results from impaired mineralization of bone that can manifest in several types, differ one another by relationships osteoid (ie, unmineralized matrix)...
• A history of head and neck irradiation in childhood or adolescence was found 22 130 patients with primary hyperparathyroidism compared only 12 400 control patients, a significant difference (P <.025). Among 200 known irradiation, biochemical surgical evidence ten, prevalence 5%. This is at least 30 times the general population The data indicate that should be regarded as an important risk factor subsequent development hyperparathyroidism. (<i>Arch Intern Med</i>140:205-207, 1980)
We compared effects of teriparatide and denosumab on PTH, bone turnover markers, histomorphometry in osteoporotic postmenopausal women. The findings were inconsistent with an early indirect anabolic effect denosumab.
ABSTRACT Previously, we reported the effects of teriparatide (TPTD) and zoledronic acid (ZOL) on bone formation based biochemical markers histomorphometry cancellous envelope at month 6 in postmenopausal women with osteoporosis who participated 12-month primary Skeletal Histomorphometry Subjects Teriparatide or Zoledronic Acid Therapy (SHOTZ) study. Patients were eligible to enter a extension their original treatment regimen: TPTD 20 μg/day (s.c. injection) ZOL 5 mg/year (i.v. infusion). A...
Background To explore underlying molecular mechanisms in the pathogenesis of symptomatic sporadic primary hyperparathyroidism (PHPT). Materials and methods Forty-one parathyroid adenomas from patients with PHPT ten normal glands either ( n =3) or euthyroid without during thyroid surgery =7) were analyzed for vitamin D receptor (VDR), calcium-sensing (CASR), cyclin D1 (CD1), hormone (PTH) expressions. The protein expressions assessed semiquantitatively by immunohistochemistry, based on...
Cyclin D1, a G1-S phase regulator, is upregulated in parathyroid adenomas. Since cyclin-dependent kinase (CDK) inhibitors, CDKN2A and CDKN2B, RASSF1A (Ras-association domain family 1, isoform A) are involved arrest act as potential tumor suppressor genes, we aimed to study methylation-mediated inactivation of these genes Gene expressions cyclin D1 (CCND1) regulatory molecules (CDKN2A, CDKN2B RASSF1A) was analysed adenoma tissues (n = 30). DNA promoter methylation regulators were assessed...
Reduced calcium sensing receptor (CaSR) expression has been implicated in parathyroid tumorigenesis, but the underlying mechanism remains elusive. Accordingly, we aimed to explore epigenetic changes (DNA methylation and histone modifications) involved CaSR regulation sporadic adenomas correlate state with disease indices.Forty 10 control tissues were studied. Real-time quantitative PCR (qPCR) for mRNA immunohistochemistry protein of performed. The status promoter 2 was determined by...
The exact mechanism causing decreased expression of the vitamin D receptor (VDR) and calcium-sensing (CASR) genes in parathyroid adenoma is not known, but methylation promoter regions often detected during epigenetic downregulation gene expression. We investigated whether silencing involved VDR CASR. Real-time PCR immunohistochemistry confirmed CASR at transcriptional translational levels. Bisulfite-converted DNA samples from adenomas with control were analyzed for region genes. There was no...