A5103252455- Autoimmune Bullous Skin Diseases
- Cancer and Skin Lesions
- Parathyroid Disorders and Treatments
- Autoimmune and Inflammatory Disorders
- Genetic and rare skin diseases.
- Skin Diseases and Diabetes
- Eosinophilic Disorders and Syndromes
- Cutaneous lymphoproliferative disorders research
- Nail Diseases and Treatments
- Leprosy Research and Treatment
- Oral Health Pathology and Treatment
- Mycobacterium research and diagnosis
- Urticaria and Related Conditions
- Infectious Diseases and Tuberculosis
- Pancreatic and Hepatic Oncology Research
- Dermatological and Skeletal Disorders
- Cancer Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Viral Infections and Immunology Research
- Acne and Rosacea Treatments and Effects
- Genital Health and Disease
- Fungal Infections and Studies
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
Post Graduate Institute of Medical Education and Research
2016-2025
Zoological Survey of India
2024
NRI Medical College
2023
Indian Institute of Science Education and Research Mohali
2023
All India Institute of Medical Sciences Bhubaneswar
2023
National Cancer Registry
2019
Kidney Health Australia
2019
Zhaotong University
2019
Henry Ford Hospital
2017
Institute of Post Graduate Medical Education and Research
2008-2012
Purpose Accurate preoperative localization of parathyroid lesion(s) is crucial for successful surgical management primary hyperparathyroidism (PHPT). This study was conducted to compare the effectiveness ultrasonography (USG) neck, 99m Tc-sestamibi (MIBI) imaging with or without SPECT/CT, and 18 F-fluorocholine (FCH) PET/CT in lesions patients PHPT. Methods Fifty-four consecutive PHPT were included this prospective who underwent using 3 diagnostic modalities followed by surgery. The...
Background and Aim: Hyperglycemia-mediated oxidative stress impedes cell-reparative process like autophagy, which has been implicated in impaired β-cell function T2DM. However, the role of mitophagy (selective mitochondrial autophagy) progression hyperglycemia remains elusive. This study aimed to assess impact increasing severity on mitophagy. Design Methods: A case-control including healthy controls, subjects with prediabetes, newly diagnosed T2DM (NDT2DM) advanced duration (ADT2DM) (n=20...
Recurrent and clinically unresponsive dermatophytosis is being increasingly encountered in our country. It runs a protracted course with exacerbations remissions. However, there little information regarding the extent of problem characteristics recurrent published literature.We sought to determine prevalence, risk factors clinical patterns institution. We also investigated causative dermatophyte species antifungal susceptibility these species.One hundred fifty patients attending outpatient...
Lichen planus pigmentosus (LPP) is a cosmetically distressing pigmentary disorder often posing therapeutic challenge. Isotretinoin has been shown to be effective in oral and cutaneous LP, but its role LPP yet unknown.To evaluate the efficacy safety of isotretinoin management LPP.In this prospective study, 32 clinically histologically proven patients with were recruited. Subjects treated fixed low-dose (20 mg/day) once daily for 6 months along topical sunscreens. Response was graded as mild...
Gallbladder cancer (GBC) is highly aggressive. Diagnosis of GBC challenging as benign gallbladder lesions can have similar imaging features. We aim to develop and validate a deep learning (DL) model for the automatic detection at abdominal ultrasound (US) compare its diagnostic performance with that radiologists. In this prospective study, multiscale, second-order pooling-based DL classifier was trained (training validation cohorts) using US data patients acquired between August 2019 June...
Background Rare variants of leprosy pose a diagnostic challenge even to astute clinicians and histoid is one such form disease with unique clinical histopathological features. There are very few large series on this entity, mainly reported from India. Objectives To study the epidemiological characteristics patients leprosy. Methods We undertook retrospective including registered clinic our tertiary care referral centre January 1991 December 2006. Data regarding demographic details, features,...
Background. Potentially lethal cardiac complications can occur in patients with acute organophosphate poisoning (OPP) and may be overlooked. Patients Methods. Thirty-six OPP were studied. Clinical features the nature of compound involved recorded. The QT interval was plotted against heart rate to determine risk for Torsades de Pointes using Fossa nomogram. Echocardiography undertaken 29 patients. Twenty-four-hour Holter monitoring performed on day 1 five Thirteen died. Necropsy hearts...
Acquired dermal macular hyperpigmentation (ADMH) is a hypernym encompassing Riehl's melanosis, lichen planus pigmentosus, and ashy dermatoses that show significant clinicopathological overlap. We sought to describe the dermatoscopic features of ADMH correlate them with histopathological findings.This was prospective observational study performed in two phases. A detailed clinical examination performed, skin biopsies were obtained 51 patients. Two dermatologists blinded dermatopathologist...
Abstract To evaluate the effect of different doses Manuka honey in experimentally induced inflammatory bowel disease rats. Adult Wistar rats either sex were used ( n = 30). Colitis was by a single intracolonic administration TNBS dissolved 35% ethanol. The 30) divided into five groups 6) and treated with vehicle (ethanol), TNBS, (5 g/kg, p.o.), (10 p.o.) or sulfasalazine (360 mg/kg, body weight for 14 days. After completion treatment, animals killed following parameters assessed:...
Background To explore underlying molecular mechanisms in the pathogenesis of symptomatic sporadic primary hyperparathyroidism (PHPT). Materials and methods Forty-one parathyroid adenomas from patients with PHPT ten normal glands either ( n =3) or euthyroid without during thyroid surgery =7) were analyzed for vitamin D receptor (VDR), calcium-sensing (CASR), cyclin D1 (CD1), hormone (PTH) expressions. The protein expressions assessed semiquantitatively by immunohistochemistry, based on...
Abstract Background Autologous non‐cultured outer root sheath hair follicle cell suspension ( NCORSHFS ) is a recently described novel cellular graft technique for the treatment of stable vitiligo. There lack data about various factors determining repigmentation rate in vitiligo patients undergoing this surgical therapy. Objective To study clinical characteristics and variables therapeutic outcome . Methods Non‐cultured was prepared from anagen hairs extracted occipital area. The number...
Cyclin D1, a G1-S phase regulator, is upregulated in parathyroid adenomas. Since cyclin-dependent kinase (CDK) inhibitors, CDKN2A and CDKN2B, RASSF1A (Ras-association domain family 1, isoform A) are involved arrest act as potential tumor suppressor genes, we aimed to study methylation-mediated inactivation of these genes Gene expressions cyclin D1 (CCND1) regulatory molecules (CDKN2A, CDKN2B RASSF1A) was analysed adenoma tissues (n = 30). DNA promoter methylation regulators were assessed...
Vitamin D (Vit.D) deficiency has been reported in alopecia areata (AA). Downregulation of receptor (VDR) on hair follicles is associated with reduced growth.To correlate serum Vit.D levels severity, pattern, and duration AA, density VDR expression over AA patients.Prospective study including 30 patients healthy controls. Clinical details measurement scalp biopsy for histopathology was performed controls at baseline after 6 months treatment AA.Mean age 28.9 ± 9.96 31.17 9.43 years,...
Reduced calcium sensing receptor (CaSR) expression has been implicated in parathyroid tumorigenesis, but the underlying mechanism remains elusive. Accordingly, we aimed to explore epigenetic changes (DNA methylation and histone modifications) involved CaSR regulation sporadic adenomas correlate state with disease indices.Forty 10 control tissues were studied. Real-time quantitative PCR (qPCR) for mRNA immunohistochemistry protein of performed. The status promoter 2 was determined by...
The exact mechanism causing decreased expression of the vitamin D receptor (VDR) and calcium-sensing (CASR) genes in parathyroid adenoma is not known, but methylation promoter regions often detected during epigenetic downregulation gene expression. We investigated whether silencing involved VDR CASR. Real-time PCR immunohistochemistry confirmed CASR at transcriptional translational levels. Bisulfite-converted DNA samples from adenomas with control were analyzed for region genes. There was no...
Children are believed to be the most vulnerable group for leprosy and childhood reflects disease transmission in community as well efficiency of ongoing control programmes. Objectives: To study epidemiological clinical trends cases at a tertiary care hospital North India during 2001-2011.A retrospective was undertaken analysing clinic records children with less than or equal 18 years registered this institute over an 11-year period. Demographic characteristics including age, sex, history...