A5063579724- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Pancreatic and Hepatic Oncology Research
- TGF-β signaling in diseases
- Metabolism, Diabetes, and Cancer
- Vitamin D Research Studies
- Pancreatitis Pathology and Treatment
- Bone health and osteoporosis research
- Magnesium in Health and Disease
- Medical Imaging and Pathology Studies
- Bone health and treatments
- Thyroid and Parathyroid Surgery
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Oral and Maxillofacial Pathology
- Infectious Diseases and Tuberculosis
- Nutrition and Health in Aging
- dental development and anomalies
- Cancer-related gene regulation
- Neuroendocrine Tumor Research Advances
- Endodontics and Root Canal Treatments
- South Asian Cinema and Culture
- Fibroblast Growth Factor Research
- Protease and Inhibitor Mechanisms
- Dental Trauma and Treatments
City of Hope
2024-2025
Ragas Dental College & Hospital
2024-2025
Post Graduate Institute of Medical Education and Research
2006-2024
Beckman Research Institute
2024
Gandhi Medical College
2023
Hamidia Hospital
2023
Sardar Patel Post Graduate Institute of Dental and Medical Sciences
2022
Indian Agricultural Research Institute
2022
Saraswati Dental College and Hospital
2020-2021
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital
2020
Purpose Accurate preoperative localization of parathyroid lesion(s) is crucial for successful surgical management primary hyperparathyroidism (PHPT). This study was conducted to compare the effectiveness ultrasonography (USG) neck, 99m Tc-sestamibi (MIBI) imaging with or without SPECT/CT, and 18 F-fluorocholine (FCH) PET/CT in lesions patients PHPT. Methods Fifty-four consecutive PHPT were included this prospective who underwent using 3 diagnostic modalities followed by surgery. The...
Epigenetic dysregulation has been reported in multiple cancers including leukemias. Nonetheless, the roles of epigenetic reader Tudor domains leukemia progression and therapy remain unexplored. Here, we conducted a domain–focused CRISPR screen identified SGF29, component SAGA/ATAC acetyltransferase complexes, as crucial factor for H3K9 acetylation, ribosomal gene expression, leukemogenesis. To facilitate drug development, integrated tiling scan with compound docking molecular dynamics...
Among the parathyroid imaging techniques, ultrasonography (USG) has advantage of convenience, easy availability and low cost.To study role USG in localization (side and/or site) abnormal glands primary hyperparathyroidism (PHPT) to compare with radionuclide scintigraphy 'gold standard', surgery.Forty-six consecutive patients undergoing anterior neck for a diagnosis PHPT whom nuclear scan (technetium-99m sestamibi thallium-201/technetium-99m pertechnetate scintigraphy) was also performed,...
The current study investigated transcriptional distortion in prostate cancer cells using the vitamin D receptor (VDR) as a tool to examine how epigenetic events driven by corepressor binding and CpG methylation lead aberrant gene expression. These relationships were non-malignant RWPE-1 that 1α,25(OH) 2 3 responsive (RWPE-1) malignant cell lines partially (RWPE-2) resistant (PC-3). studies revealed selective attenuation repression of VDR responses reflected their loss antiproliferative...
Cyclin D1, a G1-S phase regulator, is upregulated in parathyroid adenomas. Since cyclin-dependent kinase (CDK) inhibitors, CDKN2A and CDKN2B, RASSF1A (Ras-association domain family 1, isoform A) are involved arrest act as potential tumor suppressor genes, we aimed to study methylation-mediated inactivation of these genes Gene expressions cyclin D1 (CCND1) regulatory molecules (CDKN2A, CDKN2B RASSF1A) was analysed adenoma tissues (n = 30). DNA promoter methylation regulators were assessed...
Reduced calcium sensing receptor (CaSR) expression has been implicated in parathyroid tumorigenesis, but the underlying mechanism remains elusive. Accordingly, we aimed to explore epigenetic changes (DNA methylation and histone modifications) involved CaSR regulation sporadic adenomas correlate state with disease indices.Forty 10 control tissues were studied. Real-time quantitative PCR (qPCR) for mRNA immunohistochemistry protein of performed. The status promoter 2 was determined by...
Abstract Inhibin is a heterodimeric TGFβ family ligand that expressed in many cancers and selective biomarker for ovarian cancers; however, its tumor-specific functions remain unknown. Here, we demonstrate the α subunit of inhibin (INHA), which critical functionality dimeric A/B, correlates with microvessel density human tissues predictive poor clinical outcomes multiple cancers. We inhibin-regulated angiogenesis necessary metastasis. Although had no direct impact on tumor cell signaling,...
Abstract Wheat, one of the most widely consumed staple food crops globally, is relatively vulnerable to high temperature-induced heat stress. It therefore essential gain more insight into comprehensive mechanism thermotolerance wheat in order safeguard its production. In view this, we analysed stress responsive transcriptome data determine gene expression level under A total 7990 DEGs, including 4483 up-regulated and 3507 down regulated genes were identified. Gene Ontology (GO) analysis...
Fibronectin (FN) is a critical regulator of extracellular matrix (ECM) remodeling through its availability and stepwise polymerization for fibrillogenesis. Availability FN regulated by synthesis turnover, fibrillogenesis multistep, integrin-dependent process essential cell migration, proliferation, tissue function. Transforming growth factor β (TGF-β) an established ECM via transcriptional control proteins. Here we show that TGF-β, increased trafficking in transcription- SMAD-independent...
Abstract Context Primary hyperparathyroidism (PHPT) results from the hypersecretion of parathyroid hormone tumors. A transcription factor, namely Paired box1 (PAX1), is active in gland development. Objective We aimed to study potential epigenetic-mediated mechanism PAX1 gene sporadic adenomas. Methods In adenomas tissues, we analyzed DNA methylation via bisulfite-specific polymerase chain reaction (BSP) and histone modifications chromatin immunoprecipitation regulating differential...
The current study aimed to assess the topology of nuclear receptor (NR) superfamily in normal prostate epithelial cells and its distortion cancer. Both vitro silico approaches were utilized profile NRs expressed non-malignant RWPE-1 cells, which subsequently investigated by treating with 132 binary NR ligand combinations. Nine significant cooperative interactions emerged including both superadditive [22(R)-hydroxycholesterol eicosatetraenoic acid] subadditive [1α,25(OH) 2 D 3...
The frequency and predictors of pancreatitis in primary hyperparathyroidism (PHPT) are not well understood. objective the present study was to evaluate patients with PHPT its association clinical biochemical parameters disease.In this retrospective all consecutive registered registry (www.indianphptregistry.com) from year 2004 2013 were included. clinical, radiological related evaluated histologically proven patients.A total 218 (63 men; mean age: 40.6±14.4 yr) underwent surgery for during...
Abstract Background and objective The exact underlying mechanism for the differential clinical profiles of symptomatic asymptomatic primary hyperparathyroidism (PHPT) patients has not been fully elucidated, efforts to define molecular mechanisms phenotypic heterogeneity PHPT have limited. aim this study was explore involved in pathogenesis sporadic Asian Indians. Methods A prospective cohort conducted at a tertiary care hospital North India. who underwent parathyroidectomy were included....
Parathyroid carcinoma (PTC) is a rare endocrine tumor and uncommon cause for primary hyperparathyroidism. 18F-fluorocholine (FCH) positron emission tomography computed (PET/CT) has shown promising results in the detection of parathyroid adenoma, though its role PTC undefined due to paucity incidence. The authors this case report discuss possible complimentary FCH PET/CT with 18F-fluorodeoxyglucose evaluation management suspected recurrence, since entity high loco-regional distant recurrence disease.
Abstract Purpose Minimally invasive parathyroid carcinoma (MIPC) is clinically and biochemically comparable with adenoma (PA) though histopathologically differ from PA. MIPC an intermediate of PA (PC). In literature, there no definite criterion to diagnose MIPC. Our aim was evaluate characterize the imaging biochemical parameters histological characteristics Methodology Ten patients were recruited (single centre) Indian PHPT registry ( www.indianphptregistry.com ) January 2014 July 2018....
Abstract Background Primary hyperparathyroidism (PHPT) results in reduction of bone mineral density (BMD) and an increased risk pathological fractures. Curative surgery does improve BMD; however, the magnitude rise predictive factors are highly variable amongst hitherto available studies. Objectives To quantify improvement BMD after curative patients with symptomatic PHPT dissect out possible clinical biochemical parameters predicting rise. Methods We conducted a retrospective study...