A5018310651- Cancer, Lipids, and Metabolism
- Folate and B Vitamins Research
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- GDF15 and Related Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Histone Deacetylase Inhibitors Research
- Receptor Mechanisms and Signaling
- Polyamine Metabolism and Applications
Roswell Park Comprehensive Cancer Center
2011-2021
Cancer Genetics (United States)
2011-2021
University of Chicago
2017-2020
Argonne National Laboratory
2017
University at Buffalo, State University of New York
2011
Abstract ENCODE comprises thousands of functional genomics datasets, and the encyclopedia covers hundreds cell types, providing a universal annotation for genome interpretation. However, particular applications, it may be advantageous to use customized annotation. Here, we develop such custom by leveraging advanced assays, as eCLIP, Hi-C, whole-genome STARR-seq on number data-rich types. A key aspect this is comprehensive experimentally derived networks both transcription factors RNA-binding...
Genome-wide quantification of enhancer activity in the human genome has proven to be a challenging problem. Recent efforts have led development powerful tools for quantification. However, because size and complexity, these yet applied whole genome. In current study, we use prostate cancer cell line, LNCaP as model perform STARR-seq (WHG-STARR-seq) reliably obtain an assessment activity. This approach builds upon previously developed fly CapSTARR-seq techniques targeted genomic regions. With...
The current study investigated transcriptional distortion in prostate cancer cells using the vitamin D receptor (VDR) as a tool to examine how epigenetic events driven by corepressor binding and CpG methylation lead aberrant gene expression. These relationships were non-malignant RWPE-1 that 1α,25(OH) 2 3 responsive (RWPE-1) malignant cell lines partially (RWPE-2) resistant (PC-3). studies revealed selective attenuation repression of VDR responses reflected their loss antiproliferative...
Dietary folate is essential in all tissues to maintain several metabolite pools and cellular proliferation. Prostate cells, due specific metabolic characteristics, have increased demand support proliferation prevent genetic epigenetic damage. Although studies found that dietary interventions can affect colon cancer biology rodent models, its impact on prostate unknown. The purpose of this study was determine whether manipulation, possibly being primary importance for epithelial cell...
// Vineet K. Dhiman 1 , Kristopher Attwood 2 Moray J. Campbell 3 and Dominic Smiraglia Department of Cancer Genetics, Roswell Park Institute, Buffalo, NY, USA Biostatistics Bioinformatics, Pharmacology Therapeutics, Correspondence to: Smiraglia, email: Keywords : DNA methylation, androgen receptor, gene transcription, nuclear regulated target genes, Chromosome Section Received November 23, 2015 Accepted 24, Published December 04, Abstract methylation is an epigenetic modification that...
Germline KLLN promoter hypermethylation was recently identified as a potential genetic etiology of the cancer predisposition syndrome, Cowden syndrome (CS), when no causal PTEN gene mutation found. We screened for methylation in large prospective series CS patients and determined risk benign malignant features with increased both without mutation/variant unknown significance. In all, 1012 meeting relaxed International Consortium criteria including 261 mutation-positive patients, 187...
Abstract ENCODE comprises thousands of functional genomics datasets, and the encyclopedia covers hundreds cell types, providing a universal annotation for genome interpretation. However, particular applications, it may be advantageous to use customized annotation. Here, we develop such custom by leveraging advanced assays, as eCLIP, Hi-C, whole-genome STARR-seq on number data-rich types. A key aspect this is comprehensive experimentally derived networks both transcription factors RNA-binding...
Understanding the epigenetic control of normal differentiation programs might yield principal information about critical regulatory states that are disturbed in cancer. We utilized established non-malignant HPr1-AR prostate epithelial cell model upon androgen exposure commits to a luminal trajectory from basal-like state. profile dynamic transcriptome associated with this transition at multiple time points (0 h, 1 24 96 h), and confirm expression patterns strongly indicative progressive...
Abstract The archetypical co-repressors NCOR1 and NCOR2/SMRT exist in large complexes with histone deacetylases significantly control multiple transcription factors (TFs), including nuclear receptors such as the VDR AR. are altered cancer by mechanisms, mutation, but it remains unclear how this disrupts their unique shared functions either to commission or decommission enhancers through genome. Previously, we established that co-repressor recruitment prostate (CaP) induces sustained targeted...
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