A5004311331- Mitochondrial Function and Pathology
- Cell death mechanisms and regulation
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Amoebic Infections and Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cancer Cells and Metastasis
- Prostate Cancer Treatment and Research
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- COVID-19 Clinical Research Studies
- Biliary and Gastrointestinal Fistulas
- Cytokine Signaling Pathways and Interactions
- Microscopic Colitis
- Diagnosis and treatment of tuberculosis
- Helicobacter pylori-related gastroenterology studies
- Microtubule and mitosis dynamics
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
Max Super Speciality Hospital
2015-2023
Max Healthcare
2021
Post Graduate Institute of Medical Education and Research
2009-2018
St. Jude Children's Research Hospital
2017-2018
Hindu Rao Hospital
2016
The Ohio State University
2010-2015
Ohio University
2014
Hull and East Yorkshire Hospitals NHS Trust
2013
Hull Royal Infirmary
2013
Hull York Medical School
2013
Constitutive activation of signal transducer and activator transcription 3 (STAT3) signaling is frequently detected in cancer, promoting its emergence as a promising target for cancer treatment. Inhibiting constitutive STAT3 represents potential therapeutic approach. We used structure-based design to develop nonpeptide, cell-permeable, small molecule, termed LLL12, which targets STAT3. LLL12 was found inhibit phosphorylation (tyrosine 705) induce apoptosis indicated by the increases cleaved...
Interleukin (IL)-6 overexpression and constitutive STAT3 activation occur in many cancers, including prostate cancer. However, their contribution to stem progenitor cells has not been explored. In this study, we show that stem-like from patients with cancer secrete higher levels of IL-6 than counterparts non-neoplastic prostate. Tumor grade did influence the expression or secretion. Stem-like expressed receptor gp80 concomitant pSTAT3. Blockade activated STAT3, by either anti-IL-6 antibody...
Abstract Purpose: Glioblastoma multiforme (GBM) is a devastating disease. Recent studies suggest that the stem cell properties of GBM contribute to development therapy resistance. Experimental Design: The expression Survivin and Ran was evaluated by immunohistochemistry with tissues, quantitative reverse transcriptase (qRT)-PCR immunocytochemistry patient-derived sphere cultures. With computational structure-based drug design, 11 small-molecule compounds were designed, synthesized, as...
We previously reported the discovery, validation, and structure–activity relationships of a series piperidinyl ureas that potently inhibit DCN1–UBE2M interaction. demonstrated compound 7 inhibits both protein–protein interaction DCN1-mediated cullin neddylation in biochemical assays reduces levels steady-state squamous carcinoma cell line harboring DCN1 amplification. Although exhibits good solubility permeability, it is rapidly metabolized microsomal models (CLint = 170 mL/min/kg). This...
ABSTRACT Second wave of COVID-19 pandemic in India came with unexpected quick speed and intensity, creating an acute shortage beds, ventilators, oxygen at the peak occurrence. This may have been partly caused by emergence new variant delta. Clinical experience cases admitted to hospitals suggested that it is not merely a steep rise but also possibly case-profile different. study was taken up investigate differentials characteristics second versus those first wave. Records total 14398 (2020)...
Melatonin is involved in the regulation of gut motility and sensation. We aimed to determine if melatonin was effective improving bowel symptoms, extracolonic quality life (QOL) irritable syndrome (IBS) patients.Eighteen patients (aged 18 65 y; 6 females) were randomly assigned receive either 3 mg (n=9) or matching placebo at bed time for 8 weeks. The overall IBS scores, QOL scores assessed 2, 4, 6, weeks during treatment 16, 24, 48 follow up.Compared with placebo, taken significantly...
Early detection and differentiation of malignant from benign pancreatic tumors is very essential as mass-forming pancreatitis a frequently encountered problem. Positron emission tomography (PET) has role in establishing the diagnosis carcinoma when conventional imaging modalities or biopsies are nondiagnostic. In this prospective study, utility fluorodeoxyglucose (FDG)-PET/computed (CT) characterization lesions pancreas was reported.(18)F-FDG-PET/CT prospectively performed 87 patients...
To evaluate cholangiographic abnormalities resulting from extrahepatic portal venous obstruction (EHPVO) by sonography and endoscopic retrograde cholangiopancreaticography (ERCP).Forty-three patients with an established diagnosis of EHPVO were subjected to duplex Doppler ERCP. Of these, 8 had obstructive jaundice.Dilated common bile duct pericholedochal varices showing a continuous type flow pattern was seen in 5 jaundice. ERCP revealed 40 (93%). Extrahepatic ducts involved 100% cases...
ABSTRACT Primary sclerosing cholangitis (PSC) is considered to be rare in India. The aim of the present study was investigate incidence, clinical profile and outcome PSC seen a tertiary care centre. Over period 10 years (July, 1984‐June, 1994) 18 patients were diagnosed at cholangiography (14 by endoscopic retrograde cholangiopancreatography, two percutaneous transhepatic both methods). presence secondary causes, such as choledocholithiasis, biliary tract surgery, congenital anomalies,...
The virulence of Entamoeba histolytica is governed by adhesion/colonization in the gut which mediated a galactose specific lectin. Two morphologically identical but distinct species i.e. pathogenic E. and non-pathogenic dispar, can be differentiated epitopes Both bind to colonic epithelial cells, only infection induces an inflammatory response subsequent pathogenesis. Thus, comparing responses intestinal cells lectins point interest. lectin causes cytolysis immune-competent cells. Our data...
The frequency and predictors of pancreatitis in primary hyperparathyroidism (PHPT) are not well understood. objective the present study was to evaluate patients with PHPT its association clinical biochemical parameters disease.In this retrospective all consecutive registered registry (www.indianphptregistry.com) from year 2004 2013 were included. clinical, radiological related evaluated histologically proven patients.A total 218 (63 men; mean age: 40.6±14.4 yr) underwent surgery for during...
Two patients with ulcerative colitis associated Takayasu9s arteritis are described. Gangrene of a limb was the presenting feature in one patient and renovascular disease other. Angiography showed vascular occlusions affecting several medium or large sized vessels both patients.