A5044388583- Bone health and osteoporosis research
- Bone health and treatments
- Vitamin D Research Studies
- Bone Metabolism and Diseases
- Diversity and Career in Medicine
- Parathyroid Disorders and Treatments
- Medical Education and Admissions
- Innovations in Medical Education
- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Vitamin C and Antioxidants Research
- Menopause: Health Impacts and Treatments
- Health disparities and outcomes
- Hip and Femur Fractures
- Bone and Joint Diseases
- Migration, Health and Trauma
- Racial and Ethnic Identity Research
- Cultural Competency in Health Care
- Genetic Syndromes and Imprinting
- Healthcare professionals’ stress and burnout
- Nutrition, Genetics, and Disease
- Ovarian function and disorders
- Genetic Associations and Epidemiology
- Sexual Differentiation and Disorders
- Pharmacological Effects and Toxicity Studies
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Office of Diversity and Inclusion
2023
Boston University
2023
University of California, Los Angeles
2020
University of Michigan
2020
Brigham and Women's Hospital
2020
University of Pittsburgh
2020
Stony Brook University
2020
University of Colorado Denver
2020
Current approaches to diagnosing testosterone deficiency do not consider the physiological consequences of various levels or whether deficiencies testosterone, estradiol, both account for clinical manifestations.
Abstract FGF-23 is a novel regulator of phosphate metabolism. We studied the regulation by dietary in 66 men and women using two assays. Dietary restriction decreased loading increased significantly. An assay that measured intact showed effects much more clearly than an also measures presumed biologically inactive fragments. key circulating FGF-23; choice critical when studying physiology. Introduction: Fibroblast growth factor 23 (FGF-23) phosphaturic discovered through genetic studies...
Despite tremendous interest in hypoparathyroidism, large cohort studies describing typical treatment patterns, laboratory parameters, and rates of complications are lacking.Our objective was to characterize the course disease a hypoparathyroid patients.We conducted chart review patients with permanent hypoparathyroidism identified via clinical patient data registry. Patients were seen at Boston tertiary-care hospital system between 1988 2009.We 120 patients. Diagnosis confirmed by documented...
Current osteoporosis medications increase bone mineral density (BMD) modestly and reduce, but do not eliminate, fracture risk. Attempts to improve efficacy by administering anabolic agents bisphosphonates concomitantly have been unsuccessful. Conversely, 12 months of concomitant denosumab teriparatide therapy increases BMD more than either drug alone.The purpose this study was determine whether 24 combined will hip spine individual agent.Preplanned continuation the Denosumab Teriparatide...
Severe gonadal steroid deficiency induces bone loss in adult men; however, the specific roles of androgen and estrogen hypogonadal are unclear. Additionally, threshold levels testosterone estradiol that initiate uncertain.One hundred ninety-eight healthy men, ages 20-50, received goserelin acetate, which suppresses endogenous production, were randomized to treatment with 0, 1.25, 2.5, 5, or 10 grams gel daily for 16 weeks. An additional cohort 202 men was receive these treatments plus...
Aging is associated with declining gonadal steroid production, low bone mineral density (BMD), and fragility fractures. The efficacy safety of testosterone replacement in older men remains uncertain.The objective the study was to assess effects aromatase inhibition on BMD levels.This a 1-yr, double-blind, randomized, placebo-controlled trial that conducted at tertiary care academic center Boston, MA.Participants included 69 aged 60+ yr borderline or levels hypogonadal symptoms.Intervention 1...
ABSTRACT Combined teriparatide and denosumab increases spine hip bone mineral density more than either drug alone. The effect of this combination on skeletal microstructure microarchitecture, however, is unknown. Because microarchitecture are important components integrity, we performed high-resolution peripheral quantitative computed tomography (HR-pQCT) assessments at the distal tibia radius in postmenopausal osteoporotic women randomized to receive 20 µg daily (n = 31), 60 mg every 6...
In postmenopausal osteoporosis, combining denosumab and teriparatide increases hip spine bone mineral density more than either monotherapy.The objective of the study was to determine effects 2 years combination therapy on microarchitecture estimated strength.This an open-label, randomized controlled trial.We performed high-resolution peripheral quantitative computed tomography at distal tibia radius in 94 osteoporotic women 20 μg sc daily, 60 mg every 6 months, or both.Total volumetric...
Abstract Background A test that helps predict the time to final menstrual period (FMP) has been sought for many years. Objective To assess ability of antimullerian hormone (AMH) measurements predictions FMP. Design Prospective longitudinal cohort study. Setting The Study Women’s Health Across Nation. Participants and Measurements AMH FSH were measured in 1537 pre- or early perimenopausal women, mean age 47.5 ± 2.6 years at baseline, then serially until 12 months amenorrhea occurred. was...
Using race and ethnicity in clinical algorithms potentially contributes to health inequities. The American Society for Bone Mineral Research (ASBMR) Professional Practice Committee convened the ASBMR Task Force on Clinical Algorithms Fracture Risk determine impact of adjustment US Assessment Tool (US-FRAX). engaged University Minnesota Evidence-based Core conduct a systematic review investigating performance US-FRAX predicting incident fractures over 10 years Asian, Black, Hispanic, White...
This JAMA Clinical Guidelines Synopsis summarizes the Endocrine Society’s most recent recommendations on vitamin D supplementation for disease prevention.
A 1-yr extension of the Fosamax Actonel Comparison Trial was completed to compare changes in bone mineral density (BMD), turnover, and upper gastrointestinal tolerability over 2 yr treatment.This a randomized, double-blind conducted at 72 U.S. sites.Of 1053 women who 1, 833 postmenopausal with low BMD entered extension, continuing their same treatment allocation [once-weekly (OW) alendronate 70 mg or OW risedronate 35 mg]. Changes hip trochanter, total hip, femoral neck, lumbar spine markers...
We have previously demonstrated that alendronate reduces the ability of teriparatide to increase bone mineral density (BMD) in osteoporotic men. The underlying basis for this observation is poorly understood.The primary aim study was determine whether increases osteoblast activity when osteoclast suppressed by alendronate.This a nonblinded, randomized, controlled trial.The conducted at General Clinical Research Center teaching hospital.We studied 63 men, age 46-85, with low spine and/or hip...
In postmenopausal women, bone mineral density (BMD) declines after teriparatide therapy is stopped. The pattern of BMD loss stopped in men less clear.The aim the study was to determine whether teriparatide-induced accrual and post-teriparatide differs between women eugonadal men.We conducted a prospective cohort substudy.The included 14 17 men, ages 46-85 yr, with lumbar spine or femoral neck T-scores below -2.Teriparatide (37 microg sc daily) administered for 24 months, followed by 12...
Vitamin D deficiency (defined by serum levels of 25-hydroxyvitamin D) is common in patients with ESRD on hemodialysis, but risk factors are unknown. This study was conducted to determine whether routinely measured clinical and demographic parameters could identify dialysis who vitamin deficient.Nine-hundred eight were identified from the Accelerated Mortality Renal Replacement (ArMORR) cohort incident U.S. divided into training (60%) validation (40%) sets. Predictive models generated...
<h3>Importance</h3> Social distancing is critical to the control of COVID-19, which has disproportionately affected Black community. Physician-delivered messages may increase adherence these behaviors. <h3>Objectives</h3> To determine whether delivered by physicians improve COVID-19 knowledge and preventive behaviors assess differential effectiveness tailored <h3>Design, Setting, Participants</h3> This randomized clinical trial self-identified White adults with less than a college education...
To assess the association between internal medicine (IM) residents' race/ethnicity and clinical performance assessments.The authors conducted a cross-sectional analysis of assessment scores at 6 U.S. IM residency programs from 2016 to 2017. Residents underrepresented in (URiM) were identified using self-reported race/ethnicity. Standardized calculated for Accreditation Council Graduate Medical Education core competencies. Cross-classified mixed-effects regression assessed competency scores,...