A5032091908- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Cardiac pacing and defibrillation studies
- Heart Rate Variability and Autonomic Control
- ECG Monitoring and Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Neuroscience and Neural Engineering
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Vagus Nerve Stimulation Research
- EEG and Brain-Computer Interfaces
- Receptor Mechanisms and Signaling
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Electrochemical Analysis and Applications
- Tissue Engineering and Regenerative Medicine
- Wikis in Education and Collaboration
- Pain Management and Treatment
- Non-Invasive Vital Sign Monitoring
- Nonlinear Dynamics and Pattern Formation
- Misinformation and Its Impacts
Cedars-Sinai Medical Center
2007-2025
Cedars-Sinai Smidt Heart Institute
2021-2025
Harbin Medical University
2011-2024
Jiangsu Province Hospital
2014-2024
Second Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
Xuzhou Central Hospital
2022-2024
Third Affiliated Hospital of Harbin Medical University
2024
Nanjing Medical University
2013-2022
Indiana University – Purdue University Indianapolis
2012-2021
Document Reviewers: Carina Blomström-Lundqvist, MD, PhD; Angelo A.V. De Paola, Peter M. Kistler, MBBS, Gregory Y.H. Lip, MD; Nicholas S. Peters, Cristiano F. Pisani, Antonio Raviele, Eduardo B. Saad, Kazuhiro Satomi, Martin K. Stiles, MB ChB, Stephan Willems, PhD During the past three decades, catheter and surgical ablation of atrial fibrillation (AF) have evolved from investigational procedures to their current role as effective treatment options for patients with AF. Surgical AF, using...
D espite the significant decline in coronary artery disease (CAD) mortality second half of 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 300 US lives annually. 24][5][6] Because absence emergency medical response systems most world regions, worldwide estimates are currently not available. 7However, even presence advanced first responder for resuscitation out-of-hospital arrest, overall survival rate a recent North American analysis was 4.6%. 8SCD can manifest as...
Ventricular fibrillation is the leading cause of sudden cardiac death. In fibrillation, fragmented electrical waves meander erratically through heart muscle, creating disordered and ineffective contraction. Theoretical computer studies, as well recent experimental evidence, have suggested that created sustained by property restitution action potential duration (that is, its dependence on previous diastolic interval). The hypothesis states steeply sloped curves create unstable wave...
The National Heart, Lung, and Blood Institute convened an expert panel April 28 to 29, 2008, identify gaps recommend research strategies prevent atrial fibrillation (AF). reviewed the existing basic scientific, epidemiological, clinical literature about AF identified opportunities advance prevention research. After discussion, proposed following recommendations: (1) enhance understanding of epidemiology in population by systematically longitudinally investigating symptomatic asymptomatic...
Background —Sympathetic nerve activity is known to be important in ventricular arrhythmogenesis, but there little information on the relation between distribution of cardiac sympathetic nerves and occurrence spontaneous arrhythmias humans. Methods Results —We studied 53 native hearts transplant recipients, 5 obtained at autopsy patients who died noncardiac causes, 7 tissues that had been surgically resected from origin tachycardia. The history was reviewed determine presence (group 1A) or...
The factors that contribute to the occurrence of sudden cardiac death (SCD) in patients with chronic myocardial infarction (MI) are not entirely clear. present study tests hypothesis augmented sympathetic nerve regeneration (nerve sprouting) increases probability ventricular tachycardia (VT), fibrillation (VF), and SCD MI. In dogs MI complete atrioventricular (AV) block, we induced sprouting by infusing growth factor (NGF) left stellate ganglion (experimental group, n=9). Another 6 AV block...
The relationship between autonomic activation and the mechanisms of paroxysmal atrial fibrillation remains unclear.We implanted a pacemaker radio transmitter in 7 dogs (group 1). After baseline recording, we paced left atrium at 20 Hz for 1 week then monitored stellate ganglion nerve activity, vagal electrogram without pacing 24 hours. This protocol repeated itself until sustained (>48 hours) was induced 3+/-1 weeks. In another 6 2), cryoablated right ganglia cardiac branch during first...
Abstract Interstitial fibrosis plays a key role in the development and progression of heart failure. Here, we show that an enzyme crosslinks collagen—Lysyl oxidase-like 2 (Loxl2)—is essential for interstitial mechanical dysfunction pathologically stressed hearts. In mice, cardiac stress activates fibroblasts to express secrete Loxl2 into interstitium, triggering fibrosis, systolic diastolic Antibody-mediated inhibition or genetic disruption greatly reduces stress-induced chamber dilatation,...
Background —T-wave alternans, which is associated with the genesis of cardiac fibrillation, has recently been related to discordant action potential duration (APD) alternans. However, cellular electrophysiological mechanisms responsible for alternans are poorly understood. Methods and Results —We simulated a 2D sheet tissue using phase 1 Luo-Rudy model. A steep (slope >1) APD restitution curve promoted concordant T-wave without QRS When pacing was from single site, occurred only when rate...
Whether or not the muscle bundle within ligament of Marshall (LOM) can serve as origin focal atrial fibrillation (AF) is unknown.A total 28 consecutive patients with paroxysmal AF underwent balloon-occlusion coronary sinus angiograms to identify vein (VOM). Attempts were then made advance a 1.5-French electrophysiological catheter into VOM via orifice. In 17 (10 men aged 38+/-15 years), cannulation was successful. Double potentials registered in 8 these patients. The first potential...
Cardiac nerve sprouting and sympathetic hyperinnervation after myocardial infarction (MI) both contribute to arrhythmogenesis sudden death. However, the mechanisms responsible for MI are unclear. The expression of growth factor (NGF), associated protein 43 (GAP43), other markers were studied at infarcted site, noninfarcted left ventricle free wall (LVFW), stellate ganglion (LSG) several time points (30 minutes 1 month) MI. Transcardiac (difference between coronary sinus aorta) NGF levels...
Abstract —Sudden cardiac death resulting from ventricular fibrillation can be separated into 2 components: initiation of tachycardia and degeneration to fibrillation. Clinical drug studies such as CAST SWORD demonstrated that focusing exclusively on the first component is inadequate a therapeutic modality. The hope for developing effective pharmacological therapy rests comprehensive understanding second component, transition We summarize evidence spatiotemporal chaos, with similarities...
The administration of therapeutic cell types, such as stem and progenitor cells, has gained much interest for the limitation or repair tissue damage caused by a variety insults. However, it is still uncertain whether morphological functional benefits are mediated predominantly via differentiation paracrine mechanisms. Here, we assessed extent mechanisms adipose-derived stromal/stem cells (ASC)-dependent in context acute myocardial infarction. Human ASCs saline alone was injected into...