A5101406572- Gut microbiota and health
- Diet and metabolism studies
- Dietary Effects on Health
- Nutritional Studies and Diet
- Insect-Plant Interactions and Control
- Sodium Intake and Health
- Metabolomics and Mass Spectrometry Studies
- Extracellular vesicles in disease
- Insect and Pesticide Research
- Plant and animal studies
- Insect symbiosis and bacterial influences
- Meta-analysis and systematic reviews
- Geological formations and processes
- Tryptophan and brain disorders
- Nutrition, Health and Food Behavior
- Bioinformatics and Genomic Networks
- Mental Health Research Topics
- Mitochondrial Function and Pathology
- Insect and Arachnid Ecology and Behavior
- Endoplasmic Reticulum Stress and Disease
- Renal Diseases and Glomerulopathies
- Genomics and Phylogenetic Studies
- Vitamin D Research Studies
- Pregnancy and preeclampsia studies
- Antibiotic Use and Resistance
Charité - Universitätsmedizin Berlin
2020-2025
German Centre for Cardiovascular Research
2021-2025
Max Delbrück Center
2021-2025
Humboldt-Universität zu Berlin
2021-2024
Freie Universität Berlin
2021-2024
Duke University
2024
National Taiwan University
2021
National Chung Hsing University
2009-2013
National Taipei University
2009
Mackay Memorial Hospital
2008
Abstract Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. Here we show in the substudy NCT02099968, investigating clinical parameters, immunome gut microbiome exploratory endpoints, that hypertensive metabolic syndrome patients, a 5-day fast followed modified Dietary Approach to Stop Hypertension diet reduces systolic blood pressure, need for antihypertensive medications, body-mass index at three months post intervention compared alone. Fasting...
Fusion of cytotrophoblasts into the multinucleated syncytiotrophoblast layer is essential for development a functional placenta. The envelope protein human endogenous retrovirus W (HERV-W) family member, syncytin 1, has been shown to mediate placental cell fusion. Recently, another HERV member (HERV-FRD), 2, identified and be highly expressed in To better understand biology this study we first investigated 2 gene expression normal preeclamptic placentas then characterized functions 2. was...
Abstract Aims Hypertension (HTN) can lead to heart and kidney damage. The gut microbiota has been linked HTN, although it is difficult estimate its significance due the variety of other features known influence HTN. In present study, we used germ-free (GF) colonized (COL) littermate mice quantify impact microbial colonization on organ damage in Methods results 4-week-old male GF C57BL/6J littermates were randomized remain or receive colonization. HTN was induced by subcutaneous infusion with...
Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney (CKD). However, pathogenesis CVD CKD remains incompletely understood. Endothelial extracellular vesicles (EC-EVs) have previously been associated with CVD. We hypothesized that alters EV release and cargo, subsequently promoting vascular remodelling. recruited 94 children CKD, including patients after transplantation healthy donors, performed phenotyping functional analyses absence age-related comorbidities....
Abstract Summary We introduce LongDat, an R package that analyzes longitudinal multivariable (cohort) data while simultaneously accounting for a potentially large number of covariates. The primary use case is to differentiate direct from indirect effects intervention (or treatment) and identify covariates (potential mechanistic intermediates) in data. LongDat focuses on analyzing microbiome data, but its usage can be expanded other types, such as binary, categorical, continuous tested...
There is limited data on the effect of UV light exposure versus orally ingested vitamin D3 D metabolism and health. A 4-week study with 16 pigs (as a model for human physiology) was conducted. The were either supplemented 20 µg/d or exposed to 19 min/d standardise plasma 25-hydroxyvitamin levels. Important differences higher levels stored in skin subcutaneous fat, concentrations 3-epi-25-hydroxyvitamin increases cutaneous lumisterol3 UV-exposed compared pigs. supplementation resulted lower...
Abstract Aims Metformin has been attributed to cardiovascular protection even in the absence of diabetes. Recent observations suggest that metformin influences gut microbiome. We aimed investigate influence on microbiota and hypertensive target organ damage rats. Methods Male double transgenic rats overexpressing human renin angiotensinogen genes (dTGR), a model angiotensin II‐dependent hypertension, were treated with (300 mg/kg/day) or vehicle from 4 7 weeks age. assessed microbiome...
Abstract To estimate the net effect of climate change on natural populations, we must take into account positive and negative effects temperature oscillations variability. Warming because will likely exceed physiological optima tropical insects, which currently live very close to their thermal optima. Tropical insects be negatively affected if are exceeded otherwise warming may affect them positively. We evaluate demographic responses cowpea aphid, Aphis craccivora , summer in subtropical...
High salt intake ranks among the most important risk factors for noncommunicable diseases. Western diets, which are typically high in salt, associated with a prevalence of obesity. is thought to be potential factor obesity independent energy intake, although underlying mechanisms insufficiently understood. A diet could influence expenditure (EE), specifically diet-induced thermogenesis (DIT), accounts about 10% total EE. We aimed investigate on DIT. In randomized, double-blind,...
The gut microbiome of healthy individuals naturally undergoes temporal changes linked to the dynamics its community components 1 . These are only observable in longitudinal studies; they particularly relevant understanding ecosystem responses external environment disturbances. External exposures, such as antibiotic treatment, significantly reshape microbiome, impacting both pathogen and commensal microbes 2 plays pivotal roles digestion, nutrient absorption, mental health, influencing immune...
Abstract Background and Aims Cardiovascular disease (CVD) is the main cause of mortality in chronic kidney (CKD). However, pathogenesis CVD CKD remains incompletely understood. Extracellular vesicles (EVs) emerged as mediators inter-organ cross-talk endothelial EVs (EC-EVs) were previously associated with CVD. We hypothesized that drives EV release these EC-EVs drive CKD. Method A cohort 94 children (mean age 10.9 years) at different stages (patients or without dialysis after transplantation...
Abstract Background and Aims Increased dietary salt intake ranks among the most prominent nutritional risk factors worldwide has been tied to arterial hypertension all-cause mortality. The mechanisms responsible are incompletely understood have recently extended include inflammatory microbiome-associated mechanisms. Building on our preliminary data, present study investigates whether a moderate increase in healthy subjects primes host physiology more transiently unstable state, potentially...
Abstract Aims Hypertension (HTN) can lead to heart and kidney damage. The gut microbiota has been linked HTN, although it is difficult estimate its significance due the variety of other features known influence HTN. In present study, we used germ-free (GF) colonized (COL) littermate mice quantify impact microbial colonization on organ damage in Methods results Four-week-old male GF C57BL/6J littermates were randomized remain or receive colonization. HTN was induced by subcutaneous infusion...
Introduction: The gut microbiota is suspected to play a role in hypertension and hypertensive end organ damage. In the present study, we used germ-free mice demonstrate that microbial colonization modulates response stimulus. Methods: Four-week-old male C57BL6/J littermates were randomized remain (GF) or receive transfer from SPF donor achieve full status (COL). At 12 weeks, Angiotensin (Ang) II was infused s.c. for 14 days (1.44mg/kg/d, osmotic minipumps) 1% NaCl added drinking water;...