A5080152645- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Birth, Development, and Health
- Renal and related cancers
- Cardiovascular Health and Disease Prevention
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Vitamin D Research Studies
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Genetic and Kidney Cyst Diseases
- Pediatric Urology and Nephrology Studies
- Pregnancy and preeclampsia studies
- Renal Transplantation Outcomes and Treatments
- Pregnancy and Medication Impact
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Renal and Vascular Pathologies
- Adolescent and Pediatric Healthcare
- Central Venous Catheters and Hemodialysis
- Lipoproteins and Cardiovascular Health
- Biomedical Research and Pathophysiology
- Magnesium in Health and Disease
- Cardiovascular Function and Risk Factors
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2002-2023
Freie Universität Berlin
2017-2023
RELX Group (United States)
2022
Vilnius University
2022
University Medical Center Groningen
2020
University of Groningen
2020
Vivantes Klinikum
2014
Heidelberg University
1986-2013
University Hospital Heidelberg
2002-2013
Background — Cardiovascular mortality is excessive in young adults with end-stage renal disease (ESRD). The factors contributing to ESRD-related vascular are incompletely understood. Young childhood-onset chronic failure (CRF) uniquely suited for risk factor assessment because of their long-term exposure at an age when pathology the general population still minimal. Methods and Results We used novel noninvasive technologies screen coronary carotid artery 39 patients ESRD aged 19 years CRF...
Carotid intima-media thickness (cIMT) and carotid artery distensibility are reliable screening methods for vascular alterations the assessment of cardiovascular risk in adult pediatric cohorts. We sought to establish an international reference data set childhood adolescence period explore impact developmental changes body dimensions blood pressure (BP) on wall elasticity. cIMT, coefficient, incremental modulus elasticity, stiffness index β were assessed 1155 children aged 6 18 years...
Background and objectives Cardiovascular disease is the most important comorbidity affecting long-term survival in children with CKD. Design, setting, participants, & measurements The Comorbidity Children CKD Study a multicenter, prospective, observational study ages 6–17 years old initial GFR of 10–60 ml/min per 1.73 m 2 . cardiovascular status monitored annually, subclinical assessed by noninvasive surrogate markers, including left ventricular mass index, carotid intima-media...
The severe side effects of long-term corticosteroid or cyclosporin A (CsA) therapy complicate the treatment children with frequently relapsing steroid-sensitive nephrotic syndrome (FR-SSNS). We conducted a randomized, multicenter, open-label, crossover study comparing efficacy and safety 1-year mycophenolate mofetil (MMF; target plasma mycophenolic acid trough level 1.5-2.5 µg/ml) CsA (target 80-100 ng/ml) in 60 pediatric patients FR-SSNS. assessed frequency relapse as primary endpoint...
Children and adolescents with chronic kidney disease (CKD) are at high risk for cardiovascular morbidity mortality. A systemic arteriopathy cardiomyopathy has been characterized in pediatric dialysis patients by the presence of morphologic functional abnormalities.The Cardiovascular Comorbidity CKD (4C) Study is a multicenter, prospective, observational study aiming to recruit more than 600 children, aged 6 17 years, initial GFR 10 45 ml/min per 1.73 m(2). The prevalence, degree, progression...
BACKGROUND Aortic pulse wave velocity (PWV), an indicator of arterial stiffness, independently predicts cardiovascular mortality risk in adults. Arterial stiffening advances with age and seems accelerated children certain disease conditions such as chronic kidney or diabetes. The Vicorder, oscillometric device to measure PWV, has been validated children, but reference values a large pediatric cohort, association carotid stiffness influence individual family factors have not determined....
CKD is characterized by a sustained proinflammatory response of the immune system, promoting hypertension and cardiovascular disease. The underlying mechanisms are incompletely understood but may be linked to gut dysbiosis. Dysbiosis has been described in adults with CKD; however, comorbidities limit CKD-specific conclusions.We analyzed fecal microbiome, metabolites, phenotypes 48 children (with normal kidney function, stage G3-G4, G5 treated hemodialysis [HD], or transplantation) mean±SD...
Background. Studies in patients with childhood-onset end-stage renal disease (ESRD) provide a diagnostic window to the evolution of cardiovascular (CVD) this population. Hyperphosphataemia and osteodystrophy are particularly difficult treat paediatric patients, but there is only limited information regarding effect calcium-containing phosphate binders vitamin D preparations on development CVD young.
Claudin-16 (CLDN16) is critical for renal paracellular epithelial transport of Ca 2+ and Mg in the thick ascending loop Henle. To gain novel insights into role CLDN16 homeostasis pathological mechanisms underlying a human disease associated with dysfunction [familial hypomagnesemia hypercalciuria nephrocalcinosis (FHHNC), OMIM 248250], we generated mouse model deficiency. Similar to patients, CLDN16-deficient mice displayed hypomagnesemia. Contrary FHHNC was absent our model, indicating...
Pulse wave velocity (PWV) is an indicator of aortic stiffness and a predictor cardiovascular risk. Applanation tonometry (e.g., SphygmoCor) well-established method to measure PWV (aPWV). The Vicorder, new oscillometric device, has not been validated in children adolescents.We performed intra- interobserver repeatability studies 14 individuals using the Vicorder. Vicorder SphygmoCor measurements were compared 156 healthy (6-18 years) two different path length measurements.Intra-...
Abstract The peritoneum plays an essential role in preventing abdominal frictions and adhesions can be utilized as a dialysis membrane. Its physiological ultrastructure, however, has not yet been studied systematically. 106 standardized peritoneal 69 omental specimens were obtained from 107 patients (0.1–60 years) undergoing surgery for disease affecting the automated quantitative histomorphometry immunohistochemistry. mesothelial cell layer morphology protein expression pattern is similar...
Poor linear growth is a frequent complication of CKD. This study evaluated the effect kidney transplantation on age-related body segments in pediatric renal transplant recipients who were enrolled from May 1998 until August 2013 CKD Growth and Development observational cohort study.Linear (height, sitting height, arm leg lengths) was prospectively investigated during 1639 annual visits 389 ages 2-18 years with median follow-up 3.4 (interquartile range, 1.9-5.9 years). Linear mixed-effects...
The Wilms tumor suppressor gene 1 (WT1) plays an essential role in urogenital and kidney development. Genotype/phenotype correlations of WT1 mutations with renal function proteinuria have been observed world-wide cohorts nephrotic syndrome or (WT). This study analyzed mid-European patients known constitutional heterozygous WT1, including without WT. Retrospective analysis genotype, phenotype, treatment 53 mutation from all pediatric nephrology centers Germany, Austria, Switzerland performed...
Prevalence of isolated nocturnal hypertension (INH) and daytime (IDH) is around 10% in adults. Data children, especially chronic kidney disease (CKD), are lacking. The aim this cross-sectional multicenter cohort study was to define the prevalence INH IDH its association with cardiovascular morphology function, that is, pulse wave velocity (PWV), carotid intima-media thickness (cIMT), or left ventricular mass index (LVMI) children CKD.Ambulatory blood pressure (BP) monitoring profiles were...
Abstract. The effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) (calcitriol) and parathyroid hormone (PTH) on synthesis secretion lipoprotein lipase (LPL) were studied in 3T3-L1 adipocytes. Expression the vitamin D receptor was demonstrated by saturation kinetics with radiolabeled calcitriol. Incubation calcitriol (10-8 M) for up to 4 d resulted a time-dependent significant increase heparin-releasable LPL activity (LPLa) accompanied mRNA. In contrast, incubation intact (1-84) PTH (10-6 10-9...
Objective Vitamin D may contribute to cardiovascular disease in the absence of hypercalcemia patients with chronic kidney disease. Methods We investigated effects long-term (6-week) treatment 1,25(OH)2D3, at a non-hypercalcemic dosage (0.25 μg/kg per day orally) 5/6 nephrectomized rats: (i) vehicle-treated, sham-operated rats; (ii) 1,25(OH)2D3-treated, (iii) and (iv) rats. Results Creatinine clearance after 6 weeks was significantly lower parathyroid hormone levels were higher...