İpek Kaplan Bulut
A5032871828- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Pediatric Urology and Nephrology Studies
- Cardiovascular Health and Disease Prevention
- Acute Kidney Injury Research
- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Birth, Development, and Health
- Renal and Vascular Pathologies
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Urinary Tract Infections Management
- Cytomegalovirus and herpesvirus research
- Parathyroid Disorders and Treatments
- Sepsis Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Central Venous Catheters and Hemodialysis
- Ion Transport and Channel Regulation
- Urological Disorders and Treatments
- Renal function and acid-base balance
- Cardiac Arrest and Resuscitation
- Autoimmune Bullous Skin Diseases
- Kidney Stones and Urolithiasis Treatments
- Parvovirus B19 Infection Studies
- Adolescent and Pediatric Healthcare
Ege University
2014-2025
RELX Group (United States)
2022
Elazığ Eğitim ve Araştırma Hastanesi
2018
Pediatric Nephrology of Alabama
2018
Ege Üniversitesi Tıp Fakültesi Hastanesi
2014-2015
Zeynep Kamil Hospital
2011-2014
İstanbul Eğitim ve Araştırma Hastanesi
2013
Sivas Cumhuriyet Üniversitesi
2010
Significance Statement Although studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, data children are sparse. In this observational multicenter study, the authors compared HDF and hemodialysis (HD) with ESKD, finding annualized changes well validated subclinical markers of disease, including carotid intima-media thickness SD scores, were lower associated 24-hour ambulatory BP intradialytic weight gain. Height increased only cohort. Compared HD cohort,...
Prevalence of isolated nocturnal hypertension (INH) and daytime (IDH) is around 10% in adults. Data children, especially chronic kidney disease (CKD), are lacking. The aim this cross-sectional multicenter cohort study was to define the prevalence INH IDH its association with cardiovascular morphology function, that is, pulse wave velocity (PWV), carotid intima-media thickness (cIMT), or left ventricular mass index (LVMI) children CKD.Ambulatory blood pressure (BP) monitoring profiles were...
Children requiring kidney replacement therapy experience high burden of cardiovascular (CV) disease leading to increased mortality. Intima-media thickness (IMT) indicating atherosclerosis is a validated surrogate marker for future CV events.
Despite significant cardiovascular (CV) morbidity in children on dialysis and after kidney transplantation, data the evolution of CV damage with chronic disease (CKD) approaching replacement therapy (KRT) is unknown.
Background Carotid intima‐media thickness (cIMT) may identify early alterations in the vascular phenotype children with chronic kidney disease (CKD). Methods and Results Investigation of longitudinal changes cIMT SD scores (SDS) 670 patients from 4C Study (Cardiovascular Comorbidity Children With CKD Study), aged 6 to 17 years, stage 3 5 at baseline. The trajectory SDS over up 8 years was examined using a mixed‐effects model. yearly progression rate (β=0.20 [95% CI, 0.13–0.28]) remained...
BACKGROUND: Office blood pressure (BP) trajectories may help assess hypertension progression and the effects of antihypertensive treatment in children with chronic kidney disease. METHODS: Analysis BP slopes 320 patients from 4C study (Cardiovascular Comorbidity Children Chronic Kidney Disease) cohort disease before renal replacement therapy, based on a minimum 3 individual observations 2 years follow-up. RESULTS: At enrollment, 70 (22%) had uncontrolled or untreated hypertension, 130 (41%)...
Adrenarche is a component of normal pubertal development. Recent decades have witnessed changes in the timing and tempo puberty different populations. We aimed to obtain normative data on dehydroepiandrosterone-sulphate (DHEA-S) secretion healthy children evaluate age adrenarche, pubarche DHEA-S levels at which starts both sexes.Serum concentrations were measured 531 (291 female) Turkish aged 1 month-18 years by an automated chemiluminescence method. Pubic hair development was evaluated....
The uremic toxins indoxyl sulfate (IS) and p-cresyl (pCS) accumulate in patients with chronic kidney disease (CKD) as a consequence of altered gut microbiota metabolism decline renal excretion. Despite solid experimental evidence for nephrotoxic effects, the impact on progression CKD has not been investigated representative patient cohorts. In this analysis, IS pCS serum concentrations were measured 604 pediatric participants (mean eGFR 27 ± 11 ml/min/1.73m2) at enrolment into prospective...
Mortality in children with kidney failure is higher girls than boys cardiovascular complications representing the most common causes of death. Pulse wave velocity (PWV), a measure vascular stiffness, predicts mortality adults. Here, PWV undergoing replacement therapy was investigated to determine sex differences and potential contributing factors. Two-hundred thirty-five (80 girls; 34%) transplantation (150 pre-emptive, 85 prior dialysis) having at least one measurement pre- and/or...
Abstract Background Dyslipidemia is an important and modifiable risk factor for CVD in children with CKD. Methods In a cross-sectional study of baseline serum lipid levels large prospective cohort stage 3–5 (predialysis) CKD, frequencies abnormal types dyslipidemia were analyzed the entire subpopulations defined by fasting status or presence nephrotic range proteinuria. Associated clinical laboratory characteristics determined multivariable linear regression analysis. Results A total 681...
Cardiovascular disease is prevalent in children on dialysis and accounts for almost 30% of all deaths. Randomised trials adults suggest that haemodiafiltration (HDF) with high convection volumes associated reduced cardiovascular mortality compared to high-flux haemodialysis (HD); however paediatric data are scarce. We designed the haemodiafiltration, heart height (3H) study test hypothesis HDF have an improved risk profile, growth nutritional status quality life, those conventional HD....
We investigated the effects of nutritional vitamin D supplementation on markers bone and mineral metabolism, i.e. serum levels fibroblast growth factor 23 (FGF23), Klotho, alkaline phosphatase (BAP) sclerostin, in two cohorts with chronic kidney disease (CKD).In all, 80 D-deficient children were selected: 40 mild to moderate CKD from ERGO study, a randomized trial ergocalciferol [estimated glomerular filtration rate (eGFR) 55 mL/min/1.73 m2], advanced observational Cardiovascular Comorbidity...
Pseudohypoaldosteronism type 1 (PHA-1, MIM #264350) is caused by defective transepithelial sodium transport. Affected patients develop life-threatening neonatal-onset salt loss, hyperkalemia, acidosis, and elevated aldosterone levels due to end-organ resistance aldosterone. In this report, we present a patient diagnosed as PHA-1 who had clinical laboratory findings compatible with the diagnosis genetically proven autosomal recessive PHA-1. The received high doses of supplementation...
Background and objectives Although renin-angiotensin-aldosterone system inhibition (RAASi) is a cornerstone in the treatment of children with CKD, it sometimes discontinued when kidney function declines. We studied reasons RAASi discontinuation associations between important risk markers CKD progression on eGFR decline Cardiovascular Comorbidity Children study. Design, setting, participants, & measurements In this study, 69 (67% male, mean age 13.7 years, 27 ml/min per 1.73 m 2 ) who...
Patients on dialysis have a high burden of bone-related comorbidities, including fractures. We report post hoc analysis the prospective cohort study HDF, Hearts and Heights (3H) to determine prevalence risk factors for chronic kidney disease-related bone disease in children hemodiafiltration (HDF) conventional hemodialysis (HD).The baseline cross-sectional included 144 children, which 103 (61 HD, 42 HDF) completed 12-month follow-up. Circulating biomarkers formation resorption, inflammatory...
Abstract Background Continuous kidney replacement therapy (CKRT) has recently become the preferred modality for children with acute injury (AKI). We hypothesise that CKRT technical parameters and treatment settings in addition to clinical characteristics of patients may influence circuit lifetime children. Methods The study involved included EurAKId registry (NCT 02960867), who underwent treatment. analysed patient parameters. primary end point was mean (MCL). Secondary points were number...
We assessed the effect of blood pressure (BP) control on left ventricular mass index (LVMI) and hypertrophy (LVH).Ninety-six patients (64 males) ≥9 months post-kidney transplantation from 4C-T (Cardiovascular Comorbidity in Children with Chronic Kidney Disease Transplantation) study were analyzed longitudinally (mean follow-up, 2.6±1.3 years). Cumulative systolic (SBP)/diastolic BP exposure was calculated as a time-averaged area under curve categorized: ≤50th, 50th to ≤75th, 75th ≤90th,...
Background Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations and/or tract. Heat shock proteins (HSPs) expressed in response to cellular changes, such thermal, hemodynamic, osmotic, inflammatory, mechanical stresses. This study aimed assess uHSP70 levels during acute infections (UTI) non-infection periods patients with CAKUT, evaluate whether is elevated CAKUT subtypes. Methods Among 89 UTI (CAKUT-A), 111 without (CAKUT-B), 74 healthy...