Alev Yılmaz
A5003864888- Pediatric Urology and Nephrology Studies
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Kidney Stones and Urolithiasis Treatments
- Chronic Kidney Disease and Diabetes
- Complement system in diseases
- Renal and related cancers
- Urological Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Birth, Development, and Health
- Genetic and Kidney Cyst Diseases
- Renal function and acid-base balance
- Acute Kidney Injury Research
- Urinary Tract Infections Management
- Biomedical Research and Pathophysiology
- Blood Pressure and Hypertension Studies
- Cell Adhesion Molecules Research
- Heat shock proteins research
- Autoimmune Bullous Skin Diseases
- Muscle and Compartmental Disorders
- Gastroesophageal reflux and treatments
- Adolescent and Pediatric Healthcare
- Blood groups and transfusion
- Parathyroid Disorders and Treatments
- Vascular anomalies and interventions
Istanbul University
2016-2025
University of Fribourg
2024
Hôpital Civil, Strasbourg
2021-2022
Inserm
2019-2022
Université de Strasbourg
2019-2022
Dokuz Eylül University
2021
Fatih University Medical Faculty Hospital
2021
UCSI University
2018
Başkent University
2018
Ministry of Health
2015
We investigated the value of genetic, histopathologic, and early treatment response information in prognosing long-term renal outcome children with primary steroid-resistant nephrotic syndrome. From PodoNet Registry, we obtained longitudinal clinical for 1354 patients (disease onset at >3 months <20 years age): 612 had documented responsiveness to intensified immunosuppression (IIS), 1155 kidney biopsy results, 212 an established genetic diagnosis. assessed risk factors ESRD using...
The aim of the present study was to investigate risk factors antimicrobial resistance in children with urinary tract infection caused by extended-spectrum beta-lactamase (ESBL)-producing bacteria.A total 344 patients diagnosed (UTI) between January 2008 and December 2009 were enrolled this retrospective study. Causative microorganisms ESBL-producing bacteria 148 non-ESBL-producing 196 patients. There no difference two groups regarding distribution age, sex length follow up.The most frequent...
Significance Statement Although studies suggest that hemodiafiltration (HDF) may reduce cardiovascular mortality in adults, data children are sparse. In this observational multicenter study, the authors compared HDF and hemodialysis (HD) with ESKD, finding annualized changes well validated subclinical markers of disease, including carotid intima-media thickness SD scores, were lower associated 24-hour ambulatory BP intradialytic weight gain. Height increased only cohort. Compared HD cohort,...
ABSTRACT The roles of the extracellular matrix molecule tenascin-C (TNC) in health and disease have been extensively reviewed since its discovery over 40 years ago. Here, we will describe recent insights into TNC tumorigenesis, angiogenesis, immunity metastasis. In addition to high levels expression tumors, during chronic inflammation, bacterial viral infection, is also expressed lymphoid organs. This supports potential for control. Advances using murine models with engineered were...
Prevalence of isolated nocturnal hypertension (INH) and daytime (IDH) is around 10% in adults. Data children, especially chronic kidney disease (CKD), are lacking. The aim this cross-sectional multicenter cohort study was to define the prevalence INH IDH its association with cardiovascular morphology function, that is, pulse wave velocity (PWV), carotid intima-media thickness (cIMT), or left ventricular mass index (LVMI) children CKD.Ambulatory blood pressure (BP) monitoring profiles were...
Metastasis is a major cause of death in cancer patients. The extracellular matrix molecule tenascin-C known promoter metastasis, however the underlying mechanisms are not well understood. To further analyze impact on progression we generated MMTV-NeuNT mice that develop spontaneous mammary tumors, knockout background. We also developed syngeneic orthotopic model which tumor cells derived from tumor. Tumor were transfected with control shRNA or to knockdown expression and, grafted into gland...
Children requiring kidney replacement therapy experience high burden of cardiovascular (CV) disease leading to increased mortality. Intima-media thickness (IMT) indicating atherosclerosis is a validated surrogate marker for future CV events.
Randomized trials in adults have shown reduced all-cause and cardiovascular mortality on hemodiafiltration (HDF) compared to high-flux hemodialysis (HD), but the mechanisms leading improved outcomes are not clear. We studied biomarkers of inflammation, oxidative stress, anti-oxidant capacity endothelial dysfunction 22 children (13 female, age 8–15 years). All received HD for at least 3 months, were then switched HDF, keeping all dialysis related parameters time constant. inflammation...
Cancer cell plasticity contributes to therapy resistance and metastasis, which represent the main causes of cancer-related death, including in breast cancer. The tumor microenvironment drives cancer unravelling underlying cues may provide novel strategies manage metastatic disease. Using experimental models transcriptomic analyses, we showed that stem antigen-1 positive (SCA1+) murine cells enriched during progression metastasis had higher vitro cell-like properties, enhanced vivo ability,...
ABSTRACT Background Two earthquakes on 6 February 2023 destroyed 10 cities in Türkiye. We report our experience with pediatric victims during these catastrophes, a focus crush syndrome related–acute kidney injury (Crush-AKI) and death. Method Web-based software was prepared. Patient demographics, time under rubble (TUR), admission laboratory data, dialysis, overall outcomes were recorded. Results A total of 903 injured children (median age 11.62 years) evaluated. Mean TUR 13 h (interquartile...
Conventional methods to diagnose and monitor chronic kidney disease (CKD) in children, such as creatinine level cystatin C-derived estimated glomerular filtration rate (eGFR) assessment of proteinuria spot or timed urine samples, are limited value identifying patients at risk progressive function loss. Serum soluble urokinase receptor (suPAR) levels strongly predict incident CKD stage 3 adults.
The uremic toxins indoxyl sulfate (IS) and p-cresyl (pCS) accumulate in patients with chronic kidney disease (CKD) as a consequence of altered gut microbiota metabolism decline renal excretion. Despite solid experimental evidence for nephrotoxic effects, the impact on progression CKD has not been investigated representative patient cohorts. In this analysis, IS pCS serum concentrations were measured 604 pediatric participants (mean eGFR 27 ± 11 ml/min/1.73m2) at enrolment into prospective...
Autoantibodies against the podocyte protein nephrin were recently identified in a pediatric cohort primarily comprising steroid-sensitive (SSNS) and steroid-dependent (SDNS) nephrotic syndrome (NS). However, their prevalence across all NS subtypes, particularly steroid-resistant (SRNS), relation to therapy response remain need be determined advance pathophysiological understanding refine treatment strategies. A multicenter study measuring anti-nephrin autoantibodies samples from children...
Background Carotid intima‐media thickness (cIMT) may identify early alterations in the vascular phenotype children with chronic kidney disease (CKD). Methods and Results Investigation of longitudinal changes cIMT SD scores (SDS) 670 patients from 4C Study (Cardiovascular Comorbidity Children With CKD Study), aged 6 to 17 years, stage 3 5 at baseline. The trajectory SDS over up 8 years was examined using a mixed‐effects model. yearly progression rate (β=0.20 [95% CI, 0.13–0.28]) remained...
Infantile nephropathic cystinosis is a severe disease that occurs due to mutations in the gene, and it characterized by progressive dysfunction of multiple organs; >100 gene have been identified populations. Our study aimed identify clinical characteristics spectrum Turkish pediatric patients with cystinosis.We multicenter registry was established for data collection. The were extracted from this analyzed.In total, 136 (75 men 61 women) enrolled study. most common findings growth...
Cardiovascular disease is prevalent in children on dialysis and accounts for almost 30% of all deaths. Randomised trials adults suggest that haemodiafiltration (HDF) with high convection volumes associated reduced cardiovascular mortality compared to high-flux haemodialysis (HD); however paediatric data are scarce. We designed the haemodiafiltration, heart height (3H) study test hypothesis HDF have an improved risk profile, growth nutritional status quality life, those conventional HD....