Charlotte Gimpel
A5088463708- Renal and related cancers
- Genetic and Kidney Cyst Diseases
- Renal Diseases and Glomerulopathies
- Pediatric Urology and Nephrology Studies
- Blood Pressure and Hypertension Studies
- Vasculitis and related conditions
- Dialysis and Renal Disease Management
- Gastroesophageal reflux and treatments
- Congenital Heart Disease Studies
- Pharmaceutical studies and practices
- Coronary Artery Anomalies
- Cardiovascular Function and Risk Factors
- Renal cell carcinoma treatment
- Neonatal Health and Biochemistry
- Chronic Kidney Disease and Diabetes
- Renal function and acid-base balance
- Nephrotoxicity and Medicinal Plants
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Syncope and Autonomic Disorders
- Celiac Disease Research and Management
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Retinopathy of Prematurity Studies
- Williams Syndrome Research
- Ion Transport and Channel Regulation
German Center for Pediatric and Adolescent Rheumatology
2025
University Hospital Heidelberg
2009-2025
Heidelberg University
2009-2025
University Hospital Münster
2024
University Medical Center Freiburg
2014-2023
Klinikum Konstanz
2021-2023
University of Freiburg
2016-2022
Center for HIV and Hepatogastroenterology
2021
Zentrum für Kinderheilkunde
2019
Klinik und Poliklinik für Kinder- und Jugendmedizin
2014
Kidney cysts can manifest as focal disease (simple and complex kidney cysts), affect a whole (eg, multicystic dysplastic or cystic dysplasia), bilateral autosomal recessive polycystic [ARPKD] dominant [ADPKD]). In children, opposed to adults, larger proportion of are due genetic diseases HNF1B nephropathy, various ciliopathies, tuberous sclerosis complex), fewer patients have simple acquired disease. The purpose this consensus statement is provide clinical guidance on standardization imaging...
Few antihypertensive drugs are available in appropriate formulations for infants.We investigated candesartan cilexetil liquid suspension a 4-week, randomized double-blind dose-ranging study followed by 1-year open-label treatment phase (NCT00244621). The drug was administered at 0.05, 0.2 or 0.4 mg/kg per day 93 hypertensive children aged 1-5 years, of whom 74 had underlying renal disorders.A single-dose pharmacokinetic profile obtained 10 patients. At 4 weeks, SBP declined dose dependently...
The Wilms' tumor suppressor WT1 is a key regulator of podocyte function that mutated in Denys-Drash and Frasier syndromes. Here we have used an integrative approach employing ChIP, exon array, genetic analyses mice to address general isoform-specific functions differentiation. Analysis ChIP-Seq data showed almost half the podocyte-specific genes are direct targets WT1. Bioinformatic analysis further identified coactivator FOXC1-binding sites proximity WT1-bound regions, thus supporting...
The introduction of digital pathology to nephrology provides a platform for the development new methodologies and protocols visual, morphometric computer-aided assessment renal biopsies. Application imaging made substantial progress over past decade; it is now in use education, clinical trials translational research. Digital evolved as valuable tool generate comprehensive structural information form, key prerequisite achieving precision computational biology. application this technology on...
The objective of this study was to determine which the many risk factors for nephrocalcinosis (NC) in preterm infants are most relevant.In 55 neonates born before 32 completed weeks gestation, parameters relevant NC were analyzed. Median birthweight 1010 g (range 500-2070 g). Fifteen (27%) asymptomatic children had ultrasonographic NC.In multivariate analysis strongest independent factor furosemide therapy above 10 mg per kg bodyweight cumulative dose, with a 48-fold increased (odds ratio...
Background Casual office blood pressure (CBP) measurements are still standard in antihypertensive drug trials. In pediatric hypertensive trials, ethical considerations, very low disease prevalence and the marked impact of white-coat hypertension create need for sensitive reproducible techniques BP assessment. We hypothesized that ambulatory monitoring (ABPM) may identify treatment effects more sensitively than CBP thereby reduce sample sizes required Methods Standard deviations (SDs) were...
The uremic toxins indoxyl sulfate (IS) and p-cresyl (pCS) accumulate in patients with chronic kidney disease (CKD) as a consequence of altered gut microbiota metabolism decline renal excretion. Despite solid experimental evidence for nephrotoxic effects, the impact on progression CKD has not been investigated representative patient cohorts. In this analysis, IS pCS serum concentrations were measured 604 pediatric participants (mean eGFR 27 ± 11 ml/min/1.73m2) at enrolment into prospective...
We investigated the effects of nutritional vitamin D supplementation on markers bone and mineral metabolism, i.e. serum levels fibroblast growth factor 23 (FGF23), Klotho, alkaline phosphatase (BAP) sclerostin, in two cohorts with chronic kidney disease (CKD).In all, 80 D-deficient children were selected: 40 mild to moderate CKD from ERGO study, a randomized trial ergocalciferol [estimated glomerular filtration rate (eGFR) 55 mL/min/1.73 m2], advanced observational Cardiovascular Comorbidity...
IntroductionNephronophthisis (NPH) comprises a group of rare disorders accounting for up to 10% end-stage kidney disease (ESKD) in children. Prediction prognosis poses major challenge. We assessed differences survival, impact variant type, and the association clinical characteristics with declining function.MethodsData was obtained from 3 independent sources, namely network early onset cystic diseases registry (n = 105), an online survey sent out European Reference Network Rare Kidney...
Purpose.: To prospectively study plasma levels of soluble E-selectin (sE-selectin) in premature infants and to identify their relationship retinopathy prematurity (ROP) on the background known clinical risk factors. Methods.: Eighty-five sE-selectin samples from 42 preterm born at 23 32 weeks gestational age (GA) were analyzed. Twenty-two did not have ROP, eight had stage I, seven II, five III. Infants having no ROP or I designated as no-ROP group, with II III formed group. Results.: In...
The choice and timing of kidney replacement therapy (KRT) is influenced by clinical factors, laboratory features, feasibility issues, family preferences, clinicians' attitudes. We analyzed the factors associated with KRT modality in a multicenter, multinational prospective pediatric cohort study.
Nephronophthisis (NPH) comprises a heterogeneous group of inherited renal ciliopathies clinically characterized by progressive kidney failure. So far, definite diagnosis is based on molecular testing only. Here, we studied the feasibility NPHP1 and NPHP4 immunostaining nasal epithelial cells to secure accelerate NPH.
Abstract Background Atypical hemolytic uremic syndrome (aHUS) is a rare, life-threatening microangiopathy, frequently causing kidney failure. Inhibition of the terminal complement complex with eculizumab only licensed treatment but mostly requires long-term administration and risks severe side effects. The underlying genetic cause aHUS thought to influence severity initial recurring episodes, milder courses in patients mutations membrane cofactor protein ( MCP ). Methods Twenty pediatric...