A5043400881- Fetal and Pediatric Neurological Disorders
- Congenital Heart Disease Studies
- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Advanced Neuroimaging Techniques and Applications
- Coronary Artery Anomalies
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Aortic Disease and Treatment Approaches
- Atomic and Subatomic Physics Research
- Epilepsy research and treatment
- Domain Adaptation and Few-Shot Learning
- Congenital heart defects research
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Ocular Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroblastoma Research and Treatments
- Craniofacial Disorders and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Radiation Dose and Imaging
- Infectious Encephalopathies and Encephalitis
- High Altitude and Hypoxia
University Children's Hospital Zurich
2017-2025
Center for Pediatric Endocrinology Zurich
2023-2025
University of Zurich
2021-2024
University of Bern
2013-2017
University Hospital of Bern
2011-2017
Boston Children's Hospital
2014
Cairo University hospitals
2011
University of Geneva
2011
University of Tübingen
2004-2007
Universitätsklinikum Tübingen
2004-2006
It is critical to quantitatively analyse the developing human fetal brain in order fully understand neurodevelopment both normal fetuses and those with congenital disorders. To facilitate this analysis, automatic multi-tissue segmentation algorithms are needed, which turn requires open databases of segmented brains. Here we introduce a publicly available database 50 manually pathological non-pathological magnetic resonance volume reconstructions across range gestational ages (20 33 weeks)...
Abstract Children with congenital heart disease (CHD) remain at risk for neurodevelopmental impairment despite improved perioperative care. Our prospective cohort study aimed to determine the relationship between brain volumes and outcome in neonates severe CHD. Pre- postoperative cerebral MRI was acquired term born CHD undergoing neonatal cardiopulmonary bypass surgery. Brain were measured using an atlas prior-based automated method. One-year assessed Bayley-III. infants (n = 77) had lower...
Identification of geographic population-based differences in genotype and phenotype heterogeneity are important for targeted patient-specific diagnosis treatment, counseling, screening strategies.To report disease-causing variants their detailed patients with bilateral congenital cataract from a single center Switzerland thereby draw genetic map perform genotype-phenotype comparison this cohort.This clinical molecular-genetic cohort study took place through the collaboration Department...
Patients with severe congenital heart disease (CHD) are at risk for neurodevelopmental impairment. An abnormal cerebral blood supply caused by the altered cardiac physiology may limit optimal brain development. The aim of this study was to evaluate effect a systemic-to-pulmonary shunt, aortic arch obstruction and arterial oxygen saturation on perfusion in patients CHD.
BCT is a benign entity, whose appearance on conventional MR imaging makes its differentiation from neoplastic, inflammatory, or subacute ischemic disease challenging. SWI sensitive to susceptibility effects deoxyhemoglobin with excellent spatial resolution. Only scarce case reports have described the utility of in cases BCT. Our aim was show diagnostic value applied larger series cases.This an observational retrospective study 33 BCTs 27 consecutive patients examined August 2009 January 2011...
Abstract There is emerging evidence for delayed brain development in neonates with congenital heart disease. We hypothesize that the perioperative of structural connectome a proxy to such delays. Therefore, we set out quantify alterations and longitudinal pre- post-operative changes disease relative healthy term newborns assess factors contributing disturbed network development. In this prospective cohort study, 114 underwent cardiac surgery at University Children’s Hospital Zurich....
Abstract Adults with congenital heart disease are at risk for persisting executive function deficits, which known to affect academic achievement and quality of life. Alterations in white -matter microstructure associated cognitive impairments adolescents disease. This study aimed identify microstructural alterations potentially deficits adults Diffusion tensor imaging tract-based spatial statistics were conducted 45 patients (18 females) 54 healthy controls (26 aged 18–32 years. Fractional...
Congenital heart disease is the most common birth defect, and patients are at risk for neurodevelopmental impairment brain abnormalities. Yet, little known about link between volumes cognitive function in adults with congenital disease. Forty-four 53 controls 18 32 years underwent magnetic resonance imaging testing, assessed an intelligence quotient executive global score. Associations were calculated using linear models. Cognitive was within normal range (intelligence quotient: 97.74...
<h3>BACKGROUND AND PURPOSE:</h3> A uniform description of brain MR imaging findings in infants with severe congenital heart disease to assess risk factors, predict outcome, and compare centers is lacking. Our objective was uniformly describe the spectrum perioperative disease. <h3>MATERIALS METHODS:</h3> Prospective observational studies were performed at 3 European between 2009 2019. Brain preoperatively and/or postoperatively transposition great arteries, single-ventricle physiology, or...
The mitochondrial malate aspartate shuttle system (MAS) maintains the cytosolic NAD+/NADH redox balance, thereby sustaining redox-dependent pathways, such as glycolysis and serine biosynthesis. Human disease has been associated with defects in four MAS-proteins (encoded by MDH1, MDH2, GOT2, SLC25A12) sharing a neurological/epileptic phenotype, well citrin deficiency (SLC25A13) complex hepatopathic-neuropsychiatric phenotype. Ketogenic diets (KD) are high-fat/low-carbohydrate diets, which...
Abstract Arterial spin labelling (ASL), an MRI sequence non-invasively imaging brain perfusion, has yielded promising results in the presurgical workup of children with focal cortical dysplasia (FCD)-related epilepsy. However, interpretation ASL-derived perfusion patterns remains unclear. Hence, we compared ASL qualitative and quantitative findings to their clinical, EEG, counterparts. We included structural epilepsy related MRI-detectable FCD who underwent single delay pseudo-continuous...
ABSTRACT The human brain connectome is characterized by the duality of highly modular structure and efficient integration, supporting information processing. Newborns with congenital heart disease (CHD), prematurity, or spina bifida aperta (SBA) constitute a population at risk for altered development developmental delay (DD). We hypothesize that, independent etiology, alterations connectomic organization reflect neural circuitry impairments in cognitive DD. Our study aim to address this...
Abstract Objective This study was undertaken to determine whether integrating arterial spin labeling (ASL) perfusion imaging into presurgical planning improves postsurgical seizure outcomes in children with pharmacoresistant focal lesional epilepsy associated cortical dysplasia (FCD) or low‐grade epilepsy‐associated tumors (LEATs). Methods We retrospectively analyzed magnetic resonance (MRI) scans from 18 (median age = 4.8 years, interquartile range 1.9–11.5) who underwent resection for FCD‐...
Background In utero intravoxel incoherent motion magnetic resonance imaging (IVIM‐MRI) provides a novel method for examining microvascular perfusion fraction and diffusion in the developing human fetus. Purpose To characterize gestational changes of placenta, fetal liver, lungs using IVIM‐MRI. Study Type Retrospective, cross‐sectional study. Subjects Fifty‐five datasets from 33 singleton pregnancies were acquired (17–36 weeks). Field Strength/Sequence diffusion‐weighted echo‐planar at 1.5T...
Infants with congenital heart disease are at risk of brain injury and impaired neurodevelopment. The aim was to investigate factors for perioperative lesions in infants disease.Infants transposition the great arteries, single ventricle physiology, left ventricular outflow tract and/or aortic arch obstruction undergoing cardiac surgery <6 weeks after birth from 3 European cohorts (Utrecht, Zurich, London) were combined. Brain scored on preoperative (transposition arteries N=104; physiology...
Contrast-enhanced magnetic resonance imaging (MRI) is highly sensitive for assessing temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA), but only sparse data exist on normal TMJ appearance children.To determine MRI and enhancement pattern of pediatric as basis diagnosing early arthritis.In 27 children (age range, 1.2-16.8 years) without pathology undergoing head MRI, fat-saturated T2-weighted (T2W) postcontrast T1-weighted (T1W) images sagittally aligned to the...
Congenital heart defects are the most common congenital anomalies, accounting for a third of all anomaly cases. While surgical correction dramatically improved survival rates, lag behind normal neurodevelopment appears to persist. Deficits in higher cognitive functions particularly common, including developmental delay communication and oral-motor apraxia. It remains unclear whether varying degree is reflected variability brain growth patterns. To answer this question, we aimed investigate...
Although diffusion tensor imaging (DTI) may facilitate the identification of cytoarchitectural changes associated with focal cortical dysplasia (FCD), predominant aetiology paediatric structural epilepsy, its potential has thus far remained unexplored in this population. Here, we investigated whether DTI indices can differentiate FCD from contralateral brain parenchyma (CBP) and clinical features affect these indices.In single-centre, retrospective study, considered children adolescents...