A5000263730- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Intracranial Aneurysms: Treatment and Complications
- Growth Hormone and Insulin-like Growth Factors
- Cerebrovascular and Carotid Artery Diseases
- Genetic Neurodegenerative Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Meningioma and schwannoma management
- Muscle metabolism and nutrition
- Vascular Malformations Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Spinal Fractures and Fixation Techniques
- Advanced MRI Techniques and Applications
- Traumatic Ocular and Foreign Body Injuries
- Trigeminal Neuralgia and Treatments
- Acute Ischemic Stroke Management
- Spine and Intervertebral Disc Pathology
- Facial Trauma and Fracture Management
- Surgical Simulation and Training
- Radiation Dose and Imaging
- Mechanical Circulatory Support Devices
- Adipose Tissue and Metabolism
- Mesenchymal stem cell research
University Hospital of Bern
2012-2022
University of Bern
2010-2022
Jackson Memorial Hospital
2020
University of Miami
2020
Stanford University
2010-2017
Swiss Continence Foundation
2012
Cairo University hospitals
2011
University of Geneva
2011
Hospital de La Ribera
2011
University of Utah
2010
Neuronavigation has become an intrinsic part of preoperative surgical planning and procedures. However, many surgeons have the impression that accuracy decreases during surgery.To quantify decrease neuronavigation identify possible origins, we performed a retrospective quality-control study.Between April July 2011, system was used in conjunction with specially prepared head holder 55 consecutive patients. Two different systems were investigated separately. Coregistration laser-surface...
Despite the fact that consensus guidelines recommend long-term dopamine agonist (DA) therapy as a first-line approach to treatment of small prolactinoma, some patients continue prefer primary surgical approach. Concerns over potential adverse effects medical and/or desire become pregnant and avoid medication are often mentioned reasons pursue removal. In this retrospective study, 34 consecutive (30 female, 4 male) preferably underwent pituitary surgery without prior DA for prolactinomas...
Abstract Context Although consensus guidelines recommend dopamine agonists (DAs) as the first-line approach in prolactinomas, some patients may opt instead for upfront surgery, with goal of minimizing need continuation DAs over long term. While this can be recommended selected a microprolactinoma, indication surgery macroprolactinomas remains controversial, limited long-term data large cohorts. We aimed at elucidating whether is equally safe and effective micro- or not extending beyond...
This chapter contains sections titled: Abstract Phosphotransfer Enzymes: The Creatine Kinase System Microcompartments: A Principle of Life Subcellular Compartments and Microcompartments CK Tissue-specific Expression Isoenzymes Temporal Spatial Buffering Functions Kinases: CK–Phosphocreatine Circuit Closer Look at (Micro)Compartments High-energy Phosphate Channeling Compartmentation the Myofibrillar M-band: ATP Regeneration for Muscle Contraction Localization Sarcoplasmic Reticulum Plasma...
BCT is a benign entity, whose appearance on conventional MR imaging makes its differentiation from neoplastic, inflammatory, or subacute ischemic disease challenging. SWI sensitive to susceptibility effects deoxyhemoglobin with excellent spatial resolution. Only scarce case reports have described the utility of in cases BCT. Our aim was show diagnostic value applied larger series cases.This an observational retrospective study 33 BCTs 27 consecutive patients examined August 2009 January 2011...
Background: Orbital fractures associated with head trauma are not always easy to diagnose. The real incidence of such is unknown. aim this study was evaluate the usefulness routine primary computed tomographic (CT) scanning for diagnosis orbital in patients. Methods: Over a 3-year period, 600 consecutive patients admitted were examined clinically; these then underwent cranial helical CT scanning, irrespective severity injuries and presence or absence fracture-related symptoms. Results:...
Open skull fractures have been traditionally managed in 2 stages: urgent craniotomy and elevation of the fracture with removal contaminated bone, debridement, delayed cranioplasty. Primary, single-stage repair these injures has said to entail risks such as infections. Recent experience, however, disproved concerns. We used a primary reconstruction for patients presenting open depressed fractures. All received antibiotic prophylaxis. The underwent compound if necessary. Debridement was...
<h3>BACKGROUND AND PURPOSE:</h3> For patients with cerebral vasospasm refractory to medical and hemodynamic therapies, endovascular therapies often remain the last resort. Data from studies in large cohorts on efficacy safety of multiple immediate interventions are sparse. Our aim was assess feasibility repeat instant medical, hemodynamic, initial interventions. <h3>MATERIALS METHODS:</h3> This a single-center retrospective study prospectively collected data requiring ≥3 during course...
While prolactinoma patients have high bone turnover, current data are inconclusive when it comes to determining whether correction of hyperprolactinemia and associated hypogandism improves osteodensitometric in men women over the long term. In a large cohort including 40 60 women, we studied long-term impact treatment on mineral density (BMD) versus assessed adverse effects primary surgical or medical approach, evaluated for risk factors impaired BMD at last follow-up using multivariate...
Abstract Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, characterized by a prominent loss of GABA‐ergic medium‐sized spiny neurons in the caudate putamen. There evidence that impaired energy metabolism contributes to neuronal death HD. Creatine endogenous substrate for creatine kinases and thereby supports cellular ATP levels. This study investigated effects supplementation (5 m ) on cell survival differentiation striatal cultures. Chronic treatment resulted...
Cell replacement therapy using mesencephalic precursor cells is an experimental approach for the treatment of Parkinson's disease (PD). A significant problem associated with this procedure poor survival grafted neurons. Impaired energy metabolism considered to contribute neuronal cell death after transplantation. Creatine a substrate mitochondrial and cytosolic creatine kinases (CK) buffers cellular ATP resources. Furthermore, elevated levels facilitate metabolic channeling show...
Craniopharyngioma-related hypothalamic obesity is a devastating complication with limited data on whether long-term follow-up should focus problems other than endocrine deficiencies and weight gain. The primary endpoint was the assessment of predictors development; secondary functional outcome (endocrine deficiencies, visual acuity) at follow-up.This retrospective case-note study examined craniopharyngioma patients least 2 years follow-up. Clinical, radiological biochemical characteristics...
High prolactin levels have been associated with weight gain and impaired metabolic profiles. While treatment dopamine agonists (DAs) has shown to improve these parameters, there is a lack of surgical series on its comparative effect in prolactinoma patients.In this retrospective, study, consecutive patients were enrolled if treated first-line transsphenoidal surgery (TSS) or DAs. Patients prolactinomas Knosp grade >2 those follow-up <24 months excluded, as missing laboratory parameters at...
Abstract Creatine is a substrate of cytosolic and mitochondrial creatine kinases. Its supplementation augments cellular levels phosphocreatine, the rate ATP resynthesis, improves function kinase energy shuttle. High cytoplasmatic total have been reported to be neuroprotective by inhibiting apoptosis. In addition, has direct antioxidant effects, which may importance in amyotrophic lateral sclerosis. present study, we investigated effects [5 mM] on survival differentiation cultured...
Carotid endarterectomy (CEA) reduces the risk of stroke in patients with symptomatic (>50%) and asymptomatic (>60%) carotid artery stenosis. Here we report midterm results a microsurgical non-patch technique compare these findings to those literature.From 1998 2009 treated 586 consecutive CEA. CEA was performed, under general anesthesia, surgical microscope using technique. Somatosensory evoked potential transcranial Doppler were continuously monitored. Cross-clamping performed EEG burst...
Currently, there are no guidelines for neurosurgeons treating patients with Cushing's disease (CD) when intraoperative adenoma identification is negative. Under these circumstances, a total hypophysectomy or hemi-hypophysectomy on the side indicated by inferior petrosal sinus sampling (IPSS) approach being used, although subsequent risk of hypopituitarism. Data whether one-third lateral pituitary gland resection results in cure hypercortisolism and low rates hypopituitarism remain...
We report on oxygenation changes noninvasively recorded by multichannel continuous-wave near infrared spectroscopy (CW-NIRS) during endovascular neuroradiologic interventions requiring temporary balloon occlusion of arteries supplying the cerebral circulation. Digital subtraction angiography (DSA) provides reference data site, timing, and effectiveness flow stagnation as well amount direction collateral This setting allows us to relate CW-NIRS findings brain specific perfusion changes....