A5009322556- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Cerebral Venous Sinus Thrombosis
- Pituitary Gland Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Growth Hormone and Insulin-like Growth Factors
- Glioma Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Peripheral Artery Disease Management
- Migraine and Headache Studies
- Moyamoya disease diagnosis and treatment
- Blood Coagulation and Thrombosis Mechanisms
- Stroke Rehabilitation and Recovery
- Peripheral Nerve Disorders
- Cardiovascular Health and Disease Prevention
- Neurological Complications and Syndromes
- Trigeminal Neuralgia and Treatments
University Hospital of Bern
2015-2025
University of Bern
2015-2025
Regionalspital Emmental
2022
Amsterdam University Medical Centers
2020
University of Amsterdam
2020
Sanquin
2020
Medical University of Vienna
2010-2019
Université Paris Cité
2017
Massachusetts General Hospital
2017
University College London
2017
Background Reported frequency of post-stroke dysphagia in the literature is highly variable. In view progress stroke management, we aimed to assess current burden acute ischemic stroke. Methods We studied 570 consecutive patients treated a tertiary center. Dysphagia was evaluated by using Gugging Swallowing Screen (GUSS). investigated relationship with pneumonia, length hospital stay and discharge destination compared rates favourable clinical outcome mortality at 3 months between dysphagic...
There is some controversy on the association of National Institutes Health Stroke Scale (NIHSS) score to predict arterial occlusion MR arteriography and CT in acute stroke.We analyzed NIHSS scores arteriographic findings 2152 patients (35.4% women, mean age 66 ± 14 years) with anterior or posterior circulation strokes.The study included 1603 examined 549 arteriography. Of those, 1043 (48.5%; median 5, time clinical assessment 179 minutes) showed an occlusion, 887 (median 7/0-31), 156...
The goal of acute stroke treatment with intravenous thrombolysis or endovascular recanalization techniques is to rescue the penumbral tissue. Therefore, knowing factors that influence loss tissue major interest. In this study we aimed identify determine evolution penumbra in patients proximal (M1 M2) middle cerebral artery occlusion. Among these collaterals as seen on angiography were special Forty-four included analysis. They had all received therapy and at least minimal reperfusion was...
Abstract Objective: The aim of this study was to compare children and young adults with acute ischemic stroke (AIS) in 2 large registries. Methods: We compared clinical characteristics, etiology, workup, outcome (modified Rankin scale score [mRS] at 3–6 months) (1 month–16 years) (16.1–45 AIS. Data were collected prospectively the nationwide Swiss NeuroPediatric Stroke Registry, Bernese database. Outcome (mRS) severity (pediatric adaptation National Institutes Health [PedNIHSS]) calculated...
Intra-arterial thrombolysis can be used for treatment of basilar artery occlusion. Predictors outcome before initiation are special interest.From 1992 to 2010, we treated 106 consecutive patients with occlusion intra-arterial thrombolysis. Baseline characteristics, treatment, clinical course, and 3-month long-term outcomes (≥12 months) were assessed. Outcome parameters vessel recanalization after complications, modified Rankin scale (mRS) score, mortality 3 months in the long-term.At months,...
Endovascular therapy of acute ischemic stroke has been shown to be beneficial for selected patients. The purpose this study is determine predictors outcome in a large cohort patients treated with intra-arterial thrombolysis, mechanical revascularization techniques, or both.We prospectively acquired data 623 cerebral infarcts the carotid artery territory who received endovascular treatment at single center. Logistic regression analysis was performed outcome.Median National Institutes Health...
Background and Purpose- Sustained successful reperfusion is an important prognostic factor for good clinical outcome in acute ischemic stroke. We aimed to identify the prevalence, impact, predictors of early reocclusion after initially thrombectomies within a prospective cohort. Methods- A total 711 stroke patients with (modified Thrombolysis Cerebral Infarction, 2b/3) followed magnetic resonance or computed tomographic angiography at 24 48 hours were included. Multivariable logistic...
Several clinical trials have recently proven the efficacy of mechanical thrombectomy for treating ischemic stroke, within a six-hour window therapy. To move beyond treatment windows and toward personalized risk assessment, it is essential to accurately identify extent tissue-at-risk ("penumbra"). We introduce fully automated method estimate penumbra volume using multimodal MRI (diffusion-weighted imaging, T2w- T1w contrast-enhanced sequence, dynamic susceptibility contrast perfusion MRI)....
<h3>Background and purpose</h3> The use of thrombolysis in patients with minor neurological deficits large vessel occlusion is controversial. <h3>Methods</h3> We compared the outcome low National Institutes Health Stroke Scale (NIHSS) scores occlusions between thrombolysed non-thrombolysed patients. <h3>Results</h3> 88 (1.7%) 5312 consecutive acute (within 24 h) ischaemic stroke had internal carotid or main stem middle cerebral artery baseline NIHSS ≤5.47 (53.4%) were treated without...
Lesion volume on diffusion-weighted magnetic resonance imaging (DWI) before acute stroke therapy is a predictor of outcome. Therefore, patients with large volumes are often excluded from therapy. The aim this study was to analyze the impact endovascular treatment in DWI lesion (>70 mL).Three hundred seventy-two middle cerebral or internal carotid artery occlusions examined since 2004 were included. Baseline data and 3 months outcome recorded prospectively. measured semiautomatically.One five...
Serum neurofilaments are markers of axonal injury. We addressed their diagnostic and prognostic role in acute ischemic stroke (AIS) transient attack (TIA).Nested within a prospective cohort study, we compared levels serum neurofilament light chain (sNfL) drawn 24 h from symptom onset patients with AIS or TIA. Patients without magnetic resonance imaging on admission were excluded. assessed whether sNfL was associated with: (i) clinical severity admission, (ii) diagnosis vs. TIA, (iii) infarct...
To evaluate and validate the incremental value of copeptin in prediction outcome complications as compared with established clinical variables.In this prospective, multicenter, cohort study, we measured emergency room within 24 hours from symptom onset 783 patients acute ischemic stroke. The 2 primary end points were unfavorable functional (modified Rankin Scale score 3-6) mortality 90 days. Secondary any 5 prespecified during hospitalization.In multivariate analysis, higher independently...
Background and purpose Endovascular therapy is used increasingly for treatment of acute symptomatic internal carotid artery ( ICA ) occlusion, although randomized trials are lacking. Predictors outcome therefore special interest. Methods From 1992 to 2010 we treated 201 patients with occlusion intra‐arterial pharmacological thrombolysis (32), endovascular mechanical (78) or a combination both (91). All data were assessed prospectively. Results There 76/38% tandem occlusions [ plus middle MCA...
<h3>BACKGROUND AND PURPOSE:</h3> The prevalence and clinical importance of primarily fragmented thrombi in patients with acute ischemic stroke remains elusive. Whole-brain SWI was used to detect multiple thrombus fragments, their significance analyzed. <h3>MATERIALS METHODS:</h3> Pretreatment analyzed for the presence a single intracranial or thrombi. Associations baseline characteristics, complications, outcome were studied. <h3>RESULTS:</h3> Single detected 300 (92.6%), thrombi, 24 324...
Background and Purpose— Focal cerebral arteriopathy accounts for up to 35% of arterial ischemic stroke (AIS) in children is the most important predictor recurrence. The study objective was compare outcomes with focal treated combined corticosteroid antithrombotic treatment (CAT) those receiving (AT) alone. Methods— This multicenter retrospective Swiss/Australian cohort analyzed consecutive children, aged 1 month 18 years, presenting first AIS because a from 2000 2014. Children CAT were...
Randomized controlled trials have shown that bridging endovascular therapy (EVT) after intravenous thrombolysis (IVT) improves outcome in patients with stroke large-artery anterior circulation compared IVT alone. It remains unknown whether adds any benefit to EVT these patients. The aim of this study was assess recanalization rates and thrombus dislocation before initiation receiving therapy.All the Bernese registry (2008-2015) whom considered were included analysis. Relevant EVT, increase...
The diagnosis of cerebral venous thrombosis is often difficult both clinically and radiologically until now there no method available to predict if brain lesions, detected using conventional imaging methods, may lead full recovery, as expected in vasogenic edema or ischemic infarcts even a hematoma. New fast neuroimaging techniques such diffusion-weighted (DWI) are sensitive different reasons changes local tissular water concentration thus giving further insight into the pathophysiological...
Object. Brain abscesses and other purulent brain processes represent potentially life-threatening conditions for which immediate correct diagnosis is necessary to administer treatment. Distinguishing between cystic tumors often difficult using conventional imaging methods. The authors' goal was study the ability of diffusion-weighted (DW) magnetic resonance (MR) differentiate these two pathologies in patients within clinical setting. Methods. Diffusion-weighted MR studies calculation...
The purpose of the study was to compare efficacy and potential complications 2 commercially available devices for mechanical thromboembolectomy.Devices were tested in an established animal model allowing use routine angiography catheters thrombectomy devices. Radio-opaque thrombi used visualization thrombus-device interaction during angiography. Merci Retrieval System Catch Thromboembolectomy assessed each 10 vessel occlusions. For every occluded up 5 retrieval attempts performed.Sufficient...
Retrievable stents combine the high recanalization rate of and capability removing thrombus offered by mechanical thrombectomy devices. We hypothesized that retrievable shorten time to in multimodal approach for endovascular stroke treatment.Forty consecutive patients with acute ischemic undergoing therapy were included. Treatment included thromboaspiration, disruption, thrombolysis, PTA, stent placement. In 17 patients, a was used (group A) addition therapy. The remaining 23 constituted...