Jonathan G. Best
A5075641974- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Dementia and Cognitive Impairment Research
- Transcranial Magnetic Stimulation Studies
- Renal and Vascular Pathologies
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Neurological and metabolic disorders
- Cerebrovascular and Carotid Artery Diseases
- Autoimmune Neurological Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurosurgical Procedures and Complications
- Venous Thromboembolism Diagnosis and Management
- Long-Term Effects of COVID-19
- Alzheimer's disease research and treatments
- Brain Tumor Detection and Classification
- Intracranial Aneurysms: Treatment and Complications
- Ion channel regulation and function
- Medical Image Segmentation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Abdominal vascular conditions and treatments
- Stroke Rehabilitation and Recovery
University College London
2019-2025
National Hospital for Neurology and Neurosurgery
2019-2025
Biomedical Research Institute
2022-2024
Hospital de Sant Pau
2022-2024
Fujian Medical University
2020-2023
Union Hospital
2020-2023
University College London Hospitals NHS Foundation Trust
2023
Union Hospital
2020
Aalborg University
2020
Liverpool Heart and Chest Hospital
2020
Transcranial direct current stimulation (tDCS) modulates cortical excitability and is being used for human studies more frequently. Here we probe the underlying neuronal mechanisms by measuring polarity-specific changes in neurotransmitter concentrations using magnetic resonance spectroscopy (MRS). MRS provides evidence that excitatory (anodal) tDCS causes locally reduced GABA while inhibitory (cathodal) glutamatergic activity with a highly correlated reduction GABA, presumably due to close...
Rationale Atrial fibrillation causes one-fifth of ischemic strokes, with a high risk early recurrence. Although long-term anticoagulation is highly effective for stroke prevention in atrial fibrillation, initiation after usually delayed by concerns over intracranial hemorrhage risk. Direct oral anticoagulants offer significantly lower than other anticoagulants, potentially allowing earlier and recurrence, but the safety efficacy this approach has not been established. Aim Optimal timing...
The optimal timing of anticoagulation for patients with acute ischaemic stoke atrial fibrillation is uncertain. We investigated the efficacy and safety early compared delayed initiation direct oral anticoagulants (DOACs) in stroke associated fibrillation.
Poststroke cognitive impairment (PSCI) occurs in about half of stroke survivors. Cumulative evidence indicates that functional outcomes are worse women than men. Yet it is unknown whether the occurrence and characteristics PSCI differ between men women. Individual patient data from 9 cohorts patients with ischemic were harmonized pooled through Meta-VCI-Map consortium (n=2343, 38% women). We included visible symptomatic infarcts on computed tomography/magnetic resonance imaging assessment...
The association between statin use and the risk of intracranial hemorrhage (ICrH) following ischemic stroke (IS) or transient attack (TIA) in patients with cerebral microbleeds (CMBs) remains uncertain. This study investigated recurrent IS ICrH receiving statins based on presence CMBs.
Ischaemic stroke, a leading cause of death and disability, critically relies on neuroimaging for characterising the anatomical pattern injury. Diffusion-weighted imaging (DWI) provides highest expressivity in ischemic stroke but poses substantial challenges automated lesion segmentation: susceptibility artefacts, morphological heterogeneity, age-related comorbidities, time-dependent signal dynamics, instrumental variability, limited labelled data. Current U-Net-based models therefore...
Abstract Background Atrial fibrillation causes one-fifth of ischaemic strokes, with a high risk early recurrence. Although long-term anticoagulation is highly effective for stroke prevention in atrial fibrillation, initiation after can be delayed by concerns over intracranial haemorrhage risk. Direct oral anticoagulants offer significantly lower than other anticoagulants, potentially allowing earlier and recurrence, but the safety efficacy this approach has not been established. This article...
To investigate whether enlarged perivascular spaces (PVS) within the basal ganglia or deep cerebral white matter are risk factors for intracranial hemorrhage in patients taking oral anticoagulants (OACs), independent of established clinical and radiologic factors, we conducted a post hoc analysis Clinical Relevance Microbleeds Stroke (CROMIS-2) (atrial fibrillation [AF]), prospective inception cohort study.Patients with atrial recent TIA ischemic stroke underwent standardized MRI prior to...
Antibodies to glutamic acid decarboxylase (GAD), the major pathway for synthesis of c-aminobutyric acid(GABA) in humans, are found at elevated levels a subgroup patients with chronic epilepsy. To test whether antibodies were associated changes cortical GABA we used magnetic resonance spectroscopy. Four epilepsy and high serum GAD antibody (107-6,200 units/ml) 10 healthy controls recruited. A 3T GABA-optimized spectrum was obtained from reproducible voxel cortex. Compared control group,...
Post-stroke cognitive impairment (PSCI) is a common consequence of stroke. Accurate prediction PSCI risk challenging. The recently developed network impact score, which integrates information on infarct location and size with brain topology, may improve prediction. To determine if the score an independent predictor PSCI, recovery or decline. We pooled data from patients acute ischemic stroke 12 cohorts through Meta VCI Map consortium. was defined as in ≥ 1 domain neuropsychological...
Abstract Background Cerebral amyloid angiopathy (CAA) is associated with cognitive impairment, but the contributions of lobar intracerebral haemorrhage (ICH), underlying diffuse vasculopathy, and neurodegeneration, remain uncertain. We investigated domain-specific neuropsychological profile CAA without ICH, their associations structural neuroimaging features. Methods Data were collected from patients possible or probable attending a specialist outpatient clinic. Patients completed...
Background Cerebral amyloid angiopathy (CAA) is a common cause of intracerebral haemorrhage (ICH) with high recurrence risk. Left atrial appendage occlusion (LAAO) method for ischaemic stroke prevention in patients fibrillation (AF), potentially reducing the risk intracranial bleeding CAA-associated ICH. We aimed to determine outcomes AF ICH undergoing LAAO. Methods conducted multicentre study who underwent LAAO prevention. pooled our findings data from systematic review relevant published...
This is the first study to investigate functional brain activity in patients affected by autoimmune encephalitis with faciobrancial dystonic seizures (FBDS). Multimodal 3T MRI scans, including structural neuroimaging (T1-weighted, diffusion weighted) and (scene-encoding task known activate hippocampal regions), were performed. case series analysis included eight treated for FBDS, scanned during convalescent phase of their condition (median 1.1 years post-onset), healthy volunteers. Compared...
Visible perivascular spaces are an MRI marker of cerebral small vessel disease and might predict future stroke. However, results from existing studies vary. We aimed to clarify this through a large collaborative multicenter analysis.
Ischaemic renal failure in the dog was studied by clamping one artery for 2 h 18 animals. Total blood flow measured 3 after this and only reduced about 30%. Fine detail angiography showed a normal cortical perfusion pattern. Urine rates creatinine clearances from these kidneys, however, were found to be grossly impaired over period. Seven days later angiogram of oliguric kidney remained normal. Two-hour unilateral ischaemia leads form acute with striking disparity between glomerular...
In patients with ischemic stroke (IS) or transient attack (TIA) and cortical superficial siderosis (cSS), there are few data regarding the risk of future cerebrovascular events also about benefits safety antithrombotic drugs for secondary prevention. We investigated associations cSS in recent IS TIA.