Robert J. van Oostenbrugge
A5089033425- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular Health and Disease Prevention
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Artery Disease Management
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- MRI in cancer diagnosis
- Neurological Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Cerebrovascular and genetic disorders
- Neurosurgical Procedures and Complications
- Advanced X-ray and CT Imaging
- Advanced Neuroimaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Clinical practice guidelines implementation
- Cerebrospinal fluid and hydrocephalus
- Cardiac Imaging and Diagnostics
- Moyamoya disease diagnosis and treatment
- Cerebral Venous Sinus Thrombosis
Maastricht University
2016-2025
Maastricht University Medical Centre
2016-2025
University Medical Center
2010-2023
University Hospital and Clinics
2010-2023
Radboud University Nijmegen
2015-2022
Medisch Spectrum Twente
2011-2022
Radboud University Medical Center
2016-2022
Health and Education Research Management and Epidemiologic Services (United States)
2021
Cardiovascular Institute Hospital
2010-2021
Hermes Arzneimittel (Germany)
2021
In patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion, intraarterial treatment is highly effective for emergency revascularization. However, proof of beneficial effect on functional outcome lacking.
Endovascular or intra-arterial treatment (IAT) increases the likelihood of recanalization in patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion. However, beneficial effect IAT on functional recovery remains unproven. The aim this study is to assess outcome stroke. Additionally, we safety IAT, and different mechanical modalities.A multicenter randomized clinical trial blinded assessment. active comparison versus no IAT. may consist thrombolysis alteplase...
Aortic stiffness predicts an excess risk of stroke, supposedly via cerebral small-vessel disease. White matter hyperintensities, silent lacunar infarcts, and brain microbleeds, manifestations disease on neuroimaging, may precede overt cerebrovascular Therefore, we assessed whether aortic is also related to such lesions. In 167 hypertensive patients (85 men) without a history cardiovascular or disease, mean age 51.8+/-13.1 years, untreated office blood pressure levels 169+/-25/104+/-12 mm Hg,...
Recent randomized trials have proven the benefit of intra-arterial treatment (IAT) with retrievable stents in acute ischemic stroke. Patients poor or absent collaterals (preexistent anastomoses to maintain blood flow case a primary vessel occlusion) may gain less clinical from IAT. In this post hoc analysis, we aimed assess whether effect IAT was modified by collateral status on baseline computed tomographic angiography Multicenter Randomized Clinical Trial Endovascular Treatment Acute...
Intra-arterial treatment (IAT) for acute ischemic stroke caused by intracranial arterial occlusion leads to improved functional outcome in patients treated within 6 hours after onset. The influence of delay on effect is not yet known.To evaluate the time from onset start and reperfusion IAT.The Multicenter Randomized Clinical Trial Endovascular Treatment Acute Ischemic Stroke Netherlands (MR CLEAN) was a multicenter, randomized clinical open-label trial IAT vs no 500 patients. defined as...
Asymptomatic lacunar infarcts, white matter lesions, cerebral microbleeds, and enlarged perivascular spaces are MRI markers of small vessel disease (cSVD). Higher blood pressure (BP) levels associated with the presence these separately, but association total burden cSVD on brain MRI, expressed by simultaneous multiple (a compound score), has not been investigated.We performed 24-hour ambulatory BP monitoring in 122 patients first-ever stroke. On we scored each marker cSVD. One point was...
We investigated whether type 2 diabetes (T2DM) and the presence of cognitive impairment are associated with altered cerebral blood flow (CBF). Forty-one participants thirty-nine without T2DM underwent 3-Tesla MRI, including a quantitative technique measuring (macrovascular) in internal carotid artery an arterial spin labeling (microvascular) perfusion grey matter (GM). Three analysis methods were used to quantify CBF: region interest analysis, voxel-based statistical parametric mapping...
<h3>Objective:</h3> As blood–brain barrier (BBB) dysfunction may occur in normal aging but also play a pivotal role the pathophysiology of cerebral small vessel disease (cSVD), we used dynamic contrast-enhanced (DCE)–MRI to quantify rate and spatial extent BBB leakage patients with cSVD age- sex-matched controls discern cSVD-related from aging-related leakage. <h3>Methods:</h3> We performed structural brain MRI DCE-MRI 80 clinically overt 40 controls. Using Patlak pharmacokinetic model,...
Background: Randomized, clinical trials in selected acute ischemic stroke patients reported that for every hour delay of endovascular treatment (EVT), chances functional independence diminish by up to 3.4%. These findings may not be fully generalizable practice because strict in- and exclusion criteria these trials. Therefore, we aim assess the association time EVT with outcome current, everyday practice. Methods: The MR CLEAN Registry (Multicenter Randomized Clinical Trial Endovascular...
To investigate the link between blood-brain-barrier (BBB) permeability and cerebral blood flow (CBF) relation with white matter hyperintensities (WMH) in small vessel disease (cSVD).Twenty-seven patients cSVD received dynamic susceptibility contrast contrast-enhanced MRI to determine CBF BBB (expressed as leakage rate volume), respectively. Structural were segmented into normal-appearing (NAWM) WMH, for which a perilesional zone was defined. In these regions, we investigated permeability,...
Background and Purpose- The modified Rankin Scale (mRS) at 3 months is the most commonly used primary outcome measure in stroke treatment trials, but it lacks specificity requires long-term follow-up interviews, which consume time resources. An alternative may be National Institutes of Health Stroke (NIHSS), early after stroke. Our aim was to evaluate whether NIHSS assessed within 1 week could serve as a for trials acute ischemic Methods- We data from 2 randomized controlled endovascular...
The value of administering intravenous alteplase before endovascular treatment (EVT) for acute ischemic stroke has not been studied extensively, particularly in non-Asian populations.
BACKGROUND Patients with symptomatic carotid stenosis are at high risk for recurrent stroke.The decision endarterectomy currently mainly relies on degree of (cutoff value >50% or 70%).Nevertheless, also, patients mild-to-moderate still have a considerable stroke risk.Increasing evidence suggests that plaque composition rather than determines vulnerability; however, it remains unclear whether this also provides additional information to improve clinical making.OBJECTIVES The PARISK (Plaque At...
<i>Background:</i> Infections are a common and serious threat to patients with acute ischemic stroke. The aim of this study was assess the effect infection on mortality functional outcome at discharge 1 year. <i>Methods:</i> From consecutive cohort in 11 centers, Netherlands Stroke Survey, we selected 521 stroke admitted hospital within 48 h onset. Stroke-associated defined as occurring 7 days after admission. Poor (modified Rankin score >2) recorded...
Cerebral small vessel disease (CSVD) is considered to be caused by an increased permeability of the blood-brain barrier and results in enlargement Virchow Robin spaces (VRs), white matter lesions, brain microbleeds, lacunar infarcts. The may relate endothelial cell activation activated monocytes/macrophages. Therefore, we hypothesized that plasma markers (adhesion molecules) monocyte/macrophage (neopterin) CSVD manifestations. In 163 first-ever stroke patients 183 essential hypertensive...