Lukas C. van Dijk
A5086830720- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Renal and Vascular Pathologies
- Stroke Rehabilitation and Recovery
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Aortic Disease and Treatment Approaches
- Abdominal vascular conditions and treatments
- Intracranial Aneurysms: Treatment and Complications
- Coronary Interventions and Diagnostics
- Infectious Aortic and Vascular Conditions
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Disease Prevention
- Pediatric Urology and Nephrology Studies
- Cardiac Imaging and Diagnostics
- Central Venous Catheters and Hemodialysis
- Clinical practice guidelines implementation
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced X-ray and CT Imaging
- Advanced MRI Techniques and Applications
- Liver Disease and Transplantation
Haga Hospital
2015-2025
Health and Education Research Management and Epidemiologic Services (United States)
2021-2023
Radboud University Medical Center
2021
Radboud University Nijmegen
2021
Hermes Arzneimittel (Germany)
2021
Bureau van Dijk (Belgium)
2013-2020
Erasmus MC
1999-2016
University Medical Center Utrecht
2016
St. Antonius Ziekenhuis
2016
Erasmus University Rotterdam
1993-2009
In patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion, intraarterial treatment is highly effective for emergency revascularization. However, proof of beneficial effect on functional outcome lacking.
Recent randomized trials have proven the benefit of intra-arterial treatment (IAT) with retrievable stents in acute ischemic stroke. Patients poor or absent collaterals (preexistent anastomoses to maintain blood flow case a primary vessel occlusion) may gain less clinical from IAT. In this post hoc analysis, we aimed assess whether effect IAT was modified by collateral status on baseline computed tomographic angiography Multicenter Randomized Clinical Trial Endovascular Treatment Acute...
Intra-arterial treatment (IAT) for acute ischemic stroke caused by intracranial arterial occlusion leads to improved functional outcome in patients treated within 6 hours after onset. The influence of delay on effect is not yet known.To evaluate the time from onset start and reperfusion IAT.The Multicenter Randomized Clinical Trial Endovascular Treatment Acute Ischemic Stroke Netherlands (MR CLEAN) was a multicenter, randomized clinical open-label trial IAT vs no 500 patients. defined as...
Supervised exercise is recommended as a first-line treatment for intermittent claudication. Combination therapy of endovascular revascularization plus supervised may be more promising but few data comparing the 2 therapies are available.To assess effectiveness claudication compared with only.Randomized clinical trial 212 patients allocated to either or only. Data were collected between May 17, 2010, and February 16, 2013, in Netherlands at 10 sites. Patients followed up 12 months analyzed...
Background and Purpose- The modified Rankin Scale (mRS) at 3 months is the most commonly used primary outcome measure in stroke treatment trials, but it lacks specificity requires long-term follow-up interviews, which consume time resources. An alternative may be National Institutes of Health Stroke (NIHSS), early after stroke. Our aim was to evaluate whether NIHSS assessed within 1 week could serve as a for trials acute ischemic Methods- We data from 2 randomized controlled endovascular...
The value of administering intravenous alteplase before endovascular treatment (EVT) for acute ischemic stroke has not been studied extensively, particularly in non-Asian populations.
Preclinical studies showed that thrombi can be permeable and may, therefore, allow for residual blood flow in occluded arteries of patients having acute ischemic stroke. This perviousness may increase tissue oxygenation, improve thrombus dissolution, augment intra-arterial treatment success. We hypothesize the combination computed tomographic angiography noncontrast tomography imaging allows measurement contrast agent penetrating a thrombus, it is associated with improved outcome.Thrombus...
High blood pressure (BP) is associated with poor outcome and the occurrence of symptomatic intracranial hemorrhage in acute ischemic stroke. Whether BP influences benefit or safety intra-arterial treatment (IAT) not known. We aimed to assess relation functional outcome, effect IAT.This a post hoc analysis MR CLEAN (Multicenter Randomized Clinical Trial Endovascular Treatment Acute Ischemic Stroke Netherlands). was measured at baseline, before IAT stroke unit admission. estimated association...
Background and Purpose— Due to chronic hypoperfusion, cervical atherosclerosis may promote cerebral collateral circulation. We hypothesized that patients with ischemic stroke due carotid have a more extensive circulation better outcomes than cardioembolism. tested this hypothesis in population of who underwent endovascular treatment for large vessel occlusion. Methods— From the MR-CLEAN Registry (Multicenter Randomized Controlled Trial Endovascular Treatment Acute Ischemic Stroke...
The utility of computed tomographic perfusion (CTP)-based patient selection for intra-arterial treatment acute ischemic stroke has not been proven in randomized trials and requires further study a cohort that was selected based on CTP. Our objective to the relationship between CTP-derived parameters outcome effect patients with because proximal intracranial arterial occlusion.We included 175 who underwent CTP Multicenter Randomized Clinical Trial Endovascular Treatment Acute Ischemic Stroke...
A carotid web (CW) is a shelf-like lesion along the posterior wall of internal artery bulb and an underrecognized cause young stroke. Several studies suggest that patients with symptomatic CW have high risk recurrent stroke, but high-quality data are lacking.To assess 2-year stroke in CW.A comparative cohort study used from MR CLEAN trial (from 2010-2014) Registry 2014-2017). Data were analyzed September 2020. The nationwide prospective multicenter on endovascular treatment (EVT) large...
To determine the incidence of symptomatic and asymptomatic cerebral ischemic lesions found on diffusion-weighted magnetic resonance imaging (DW-MRI) after carotid interventions.A prospective study was conducted to assess new using DW-MRI in patients with artery disease undergoing protected stenting (CAS) or endarterectomy (CEA). performed before intervention 44 (21 CAS 23 CEA). Two experienced radiologists not involved procedures neurological assessment compared postprocedural DW-MR images...
Clinical outcomes reported after treatment of infrapopliteal lesions with drug-eluting stents (DESs) have been more favorable compared percutaneous transluminal angioplasty a bailout bare metal stent (PTA-BMS) through midterm follow-up in patients critical limb ischemia. In the present study, long-term results DESs are presented.Adults ischemia (Rutherford category ≥4) and were randomized to receive PTA-BMS or paclitaxel. Long-term consisted annual assessments up 5 years until clinical end...
Background— Endovascular infrapopliteal treatment of patients with critical limb ischemia using percutaneous transluminal angioplasty (PTA) and bail-out bare metal stenting (BMS) is hampered by restenosis. In interventional cardiology, drug-eluting stents (DES) have shown better patency rates are standard practice nowadays. An investigator-initiated, multicenter, randomized trial was conducted to assess whether DES also improve clinical outcome lesions. Methods Results— Adults (Rutherford...
<h3>Objective</h3> To explore clinical outcomes in older adults with acute ischemic stroke treated endovascular thrombectomy (EVT). <h3>Methods</h3> We included consecutive patients (2014–2016) an anterior circulation occlusion undergoing EVT from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke Netherlands (MR CLEAN) Registry. assessed effect age (dichotomized at ≥80 years and as continuous variable) on modified Rankin Scale (mRS) score 90 days,...
Background It is unclear whether intravenous thrombolysis ( IVT ) with alteplase before endovascular treatment EVT beneficial for patients acute ischemic stroke caused by a large vessel occlusion. We compared clinical and procedural outcomes, safety, workflow between treated both those alone in routine practice. Methods Results Using multivariable regression, we evaluated the association of + 90-day functional outcome (modified Rankin Scale), mortality, reperfusion, first-pass effect,...
Background and Purpose— Collateral circulation status at baseline is associated with functional outcome after ischemic stroke effect of endovascular treatment. We aimed to identify clinical imaging determinants that are collateral grade on computed tomography angiography in patients acute due an anterior large vessel occlusion. Methods— Patients included the MR CLEAN trial (Multicenter Randomized Clinical Trial Endovascular Treatment for Acute Ischemic Stroke Netherlands; n=500) Registry...
We evaluated data from all patients in the Netherlands who underwent endovascular treatment for acute ischemic stroke past 3.5 years, to identify nationwide trends time and procedural success, assess their effect on clinical outcomes.We included with proximal occlusions of anterior circulation second first cohorts MR CLEAN (Multicenter Randomized Clinical trial Endovascular Treatment Acute Ischemic Stroke Netherlands) Registry (March 2014 June 2016; 2016 November 2017, respectively)....
Importance Outcome prediction after endovascular treatment (EVT) for ischemic stroke is important to patients, family members, and physicians. Objective To develop validate a model based on preprocedural postprocedural characteristics predict functional outcome individual patients EVT. Design, Setting, Participants A was developed using patient data from 7 randomized clinical trials, performed between December 2010 2014. The within the Highly Effective Reperfusion Evaluated in Multiple...