A5027129526- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Cardiac Imaging and Diagnostics
- Acute Ischemic Stroke Management
- Glaucoma and retinal disorders
- Adipose Tissue and Metabolism
- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Optical Imaging and Spectroscopy Techniques
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Effects of Exercise
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Valve Diseases and Treatments
- NMR spectroscopy and applications
- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- MRI in cancer diagnosis
- Renal and Vascular Pathologies
- Pediatric Hepatobiliary Diseases and Treatments
- Cerebrospinal fluid and hydrocephalus
Haga Hospital
2017-2023
University Medical Center Utrecht
2022
Erasmus MC
2022
Juliana Kinderziekenhuis
2020
Medisch Centrum Haaglanden
2018
Leiden University Medical Center
2007-2017
University Medical Center
2013-2014
Leiden University
2007-2013
University Medical Center Hamburg-Eppendorf
2011
Loyola University Medical Center
2011
The natural history of non-functioning pituitary macroadenomas (NFMA) has not been completely elucidated. Therefore, we evaluated function, visual fields, and tumor size during long-term follow-up non-operated patients with NFMA.Follow-up study.Twenty-eight (age 55 +/- 3 years) NFMA, operated after initial diagnosis, were included.Initial presentation was insufficiency in 44%, field defects 14%, apoplexy chronic headache 7% the patients. duration 85 13 months. Radiological evidence growth...
Die Kurzform des Brief Symptom Inventory (BSI-18) ist ein anwendungsökonomisches, reliables und valides Selbstbeurteilungsverfahren, das zunehmende internationale Verbreitung findet. Mit je 6 Items werden die Syndrome Somatisierung, Depressivität Ängstlichkeit abgebildet. Für teststatistische Evaluation der deutschen Version wurden Studenten, nicht klinische Probanden ambulante psychosomatische Patienten untersucht. Alle Skalen zeigten über verschiedenen Stichproben hinweg befriedigende bis...
To validate 3-dimensional (3D) 3-directional velocity-encoded (VE) magnetic resonance imaging (MRI) for flow assessment through all 4 heart valves simultaneously with retrospective valve-tracking during off-line analysis in healthy volunteers and patients valvular regurgitation.Three-dimensional VE MRI was performed 22 29 ischemic cardiomyopathy who were suspected of regurgitation net volumes the compared. Furthermore, repeated each valve 10 regurgitant to assess intra- interobserver...
Abstract Segmentation of anatomical structures is valuable in a variety tasks, including 3D visualization, surgical planning, and quantitative image analysis. Manual segmentation time-consuming deals with intra inter-observer variability. To develop deep-learning approach for the fully automated inner ear MRI, U-net was trained on 944 MRI scans manually segmented ears as reference standard. The model validated an independent, multicentric dataset consisting 177 from three different centers....
Diabetes and obesity are associated with increased plasma nonesterified fatty acid (NEFA) levels, myocardial triglyceride accumulation, dysfunction. Because a very low-calorie diet (VLCD) also increases NEFA we studied the effect of VLCD on content cardiac function in healthy subjects.Fourteen nonobese men underwent (1)H-magnetic resonance spectroscopy (MRS) to determine hepatic content, (31)P-MRS assess high-energy phosphate (HEP) metabolism (phosphocreatine/ATP), magnetic imaging at...
In animal models of obesity and diabetes mellitus, myocardial TG accumulation is associated with decreased function. the physiologically ageing heart, triglyceride (TG) may also occur due to reduced fatty acid oxidation. The role in human heart unknown. Therefore, purpose our study was evaluate effects on content, determine association between content function.1H-magnetic resonance spectroscopy magnetic imaging were performed 43 healthy male subjects. Mean age (range) subjects 44 (20-66)...
Institutional review board approval and informed consent were obtained. The purpose of the study was to prospectively compare spectral resolution reproducibility hydrogen 1 (1H) magnetic resonance (MR) spectroscopy, with without respiratory motion compensation based on navigator echoes, in assessment myocardial triglyceride content human heart. In 20 volunteers (14 men, six women; mean age ± standard error, 31 years 2.8 [range, 19–60 years]; body mass index, 19–30 kg/m2) history...
An association has been suggested between elevated plasma nonesterified fatty acid (NEFA) levels, myocardial triglyceride (TG) accumulation, and function.Our objective was to investigate the effects of an elevation NEFA by a high-fat, high-energy (HFHE) diet on hepatic TG function.There were 15 healthy males (mean +/- sd age: 25.0 6.6 yr) subjected 3-d HFHE consisting their regular diet, supplemented with 800 ml cream (280 g fat) every day.(1)H-magnetic resonance spectroscopy performed for...
In animal experiments, high plasma concentrations of free fatty acids (FFAs) are associated with increased triglyceride (TG) stores in liver and heart, impaired cardiac function. humans caloric restriction increases FFA levels.Our objective was to assess the effects progressive on myocardial hepatic TG content function.This a prospective intervention study.This study included 10 lean healthy men.Three-day partial (471 kcal/d) complete starvation performed.Plasma levels FFA, content, function...
Pericardial fat accumulation has been associated with an increased cardiovascular risk. A very low calorie diet (VLCD) improves the risk profile in patients type 2 diabetes mellitus (T2DM), by improving metabolic profile, heart function, and triglyceride (TG) stores (non)adipose tissues. However, long-term effects of a VLCD on pericardial volume tissue-specific TG have not documented. The aim this study was therefore to assess 16-week subsequent 14 months follow-up regular relation other...
<h3>BACKGROUND AND PURPOSE:</h3> Ménière disease is characterized by endolymphatic hydrops, whereas perilymphatic enhancement on MR imaging has been suggested to be of additional value in diagnosing disease. This study evaluates the presence hydrops and patients with other vertigo-associated inner ear pathology. <h3>MATERIALS METHODS:</h3> A 3D-FLAIR sequence 4 hours after intravenous gadolinium injection was performed visualize endolymph perilymph 220 suspected having Patients’ ears were...
We evaluated data from all patients in the Netherlands who underwent endovascular treatment for acute ischemic stroke past 3.5 years, to identify nationwide trends time and procedural success, assess their effect on clinical outcomes.We included with proximal occlusions of anterior circulation second first cohorts MR CLEAN (Multicenter Randomized Clinical trial Endovascular Treatment Acute Ischemic Stroke Netherlands) Registry (March 2014 June 2016; 2016 November 2017, respectively)....
Objectives To analyze the frequency of intra-abdominal Candida infection during acute necrotizing pancreatitis and to compare outcome patients without infections. Design Retrospective analysis data from 37 with infection. Setting Surgical intensive care unit (ICU) in a university hospital. Patients Thirty-seven pancreatitis. Interventions were subject necrosectomy programmed lavage. Measurements Main Results Clinical parameters contained Acute Physiology Chronic Health Evaluation (APACHE) II...
Short-term caloric restriction increases plasma levels of nonesterified fatty acids (NEFAs) and is associated with increased myocardial triglyceride (TG) content decreased function in healthy subjects. Whether this flexibility TG stores also present patients type 2 diabetes mellitus (T2DM) yet unknown. Myocardial left ventricular (LV) ratio between the early (E) atrial (A) diastolic filling phase (E/A) were determined using magnetic resonance (MR) spectroscopy MR imaging, respectively,...
Abstract The post‐traumatic status of antemortem fractures in human dry bone remains is currently defined as being either ‘healing’ or ‘healed’. However, detailed ‘dating’ the related time interval would be desirable, since it aid assessing individual medical and care at death. Within forensic pathology practice, fresh tissue healing phases are routinely used an intrinsic parameter for length interval. Unfortunately, direct application such a method hampered when applied to skeletal...
To prospectively assess the effects of an exercise intervention on organ-specific fat accumulation and cardiac function in type 2 diabetes mellitus.Written informed consent was obtained from all participants, study protocol approved by medical ethics committee. The followed 12 patients with mellitus (seven men; mean age, 46 years ± [standard error]) before after 6 months moderate-intensity exercise, a high-altitude trekking expedition long duration. Abdominal, epicardial, paracardial volume...
Using a mouse model for human-like lipoprotein metabolism, we observed previously that reduction of the hepatic triglyceride (TG) content resulted in decrease plasma cholesteryl ester transfer protein (CETP) and an increase HDL levels. The aim current study was to investigate effects prolonged caloric restriction obese patients with type 2 diabetes mellitus, resulting major TG content, on CETP levels.We studied 27 (BMI: 37.2 ± 0.9 kg/m(2)) insulin-dependent mellitus (14 men 13 women, aged 55...
Abstract Background Despite evidence of a quite large beneficial effect endovascular treatment (EVT) for ischemic stroke caused by anterior circulation vessel occlusion, many patients do not recover even after complete recanalization. To some extent, this may be attributable to incomplete microvascular reperfusion, which can possibly improved antiplatelet agents and heparin. It is unknown whether periprocedural antithrombotic medication in treated with EVT improves functional outcome. The...