A5061356869- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Cardiac Valve Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Congenital Heart Disease Studies
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Adipose Tissue and Metabolism
- Coronary Interventions and Diagnostics
- Advanced X-ray and CT Imaging
- Cerebrovascular and Carotid Artery Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Aortic aneurysm repair treatments
- Cardiac electrophysiology and arrhythmias
- Medical Imaging Techniques and Applications
- Cardiac pacing and defibrillation studies
- MRI in cancer diagnosis
- Diet, Metabolism, and Disease
- Atomic and Subatomic Physics Research
- Dietary Effects on Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
Leiden University Medical Center
2016-2025
Leiden University
2012-2024
Weatherford College
2024
Loyola University Medical Center
2011-2023
Erasmus University Rotterdam
2006-2022
Erasmus MC
2011-2022
Delft University of Technology
2022
De Gezondheidsdienst voor Dieren
2022
Imaging Center
2021
University of Leeds
2018
Currently, one third of patients treated with cardiac resynchronization therapy (CRT) do not respond. Nonresponse to CRT may be explained by the presence scar tissue in posterolateral left ventricular (LV) segments, which result ineffective LV pacing and inadequate resynchronization. In present study, relationship between transmural response was evaluated.Forty consecutive end-stage heart failure (NYHA class III/IV), ejection fraction < or =35%, QRS duration >120 ms, bundle-branch block,...
The relation between infarct tissue heterogeneity on contrast-enhanced MRI and the occurrence of spontaneous ventricular arrhythmia (or sudden cardiac death) is unknown. Therefore, study purpose was to evaluate predictive value assessed with subsequent implantable cardioverter-defibrillator (ICD) therapy (as surrogate in patients previous myocardial infarction.Ninety-one (age, 65+/-11 years) infarction scheduled for ICD implantation underwent cine left function volumes characterization scar...
Body fat distribution is, next to overall obesity, an important risk factor for cardiometabolic outcomes in the general population. In particular, visceral adipose tissue (VAT) is strongly associated with factors. Since it unclear whether body also men and women obesity we investigated associations between measures of factors obesity.In this cross-sectional analysis obese (BMI≥30 kg/m2) included Netherlands Epidemiology Obesity Study, waist:hip ratio(WHR), waist circumference, MRI-based...
The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage. Ectopic associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but accumulation intermediates lipid metabolism organs, such as liver, skeletal muscle, heart seem to disrupt metabolic processes impair organ function. We describe mechanisms depositions around consequences for each organs In addition, we systematically reviewed literature effects...
Abdominal obesity is a well-established risk factor for the development of type 2 diabetes. However, sex differences may exist. We aimed to investigate associations abdominal subcutaneous adipose tissue (SAT) and visceral (VAT) with insulin resistance secretion in men women.In this cross-sectional analysis Netherlands Epidemiology Obesity study, fasting postprandial concentrations glucose were measured fat depots assessed using magnetic resonance imaging 2253 participants (53% women). With...
Purpose To develop a deep learning–based method for fully automated quantification of left ventricular (LV) function from short-axis cine MR images and to evaluate its performance in multivendor multicenter setting. Materials Methods This retrospective study included MRI data sets obtained three major vendors four medical centers 2008 2016. Three convolutional neural networks (CNNs) with the U-NET architecture were trained on increasing variability: (a) single-vendor, single-center,...
Background Obesity has been associated with increased risk of accelerated cognitive decline and dementia, which suggests underlying neurobiological changes. Purpose To investigate the associations between obesity brain structure (overall regional volumes, white matter microstructure) assessed at MRI in a sample general population. Materials Methods Between March 2014 January 2018, 12 087 participants (52.8% women [6381 087]; mean age, 62 years; age range, 45–76 years) prospective...
The authors studied the reproducibility of repeated measurements left ventricular volumes, weight, and wall stress as determined with cine spin-echo magnetic resonance (MR) imaging. Two observers analyzed 40 serial MR imaging examinations twice, yielding a total 160 measurements. Estimates 95% ranges for change were ejection fraction, 10% 12%; mass, 16% 21%; stress, 22% 20%, derived from imaging, respectively. Reproducibility was not significantly different between Intraobserver,...
Hypertension is an important clinical problem and often accompanied by left ventricular (LV) hypertrophy dysfunction. Whether the myocardial high-energy phosphate (HEP) metabolism altered in human hypertensive heart disease whether this associated with LV dysfunction not known.Eleven patients hypertension 13 age-matched healthy subjects were studied magnetic resonance imaging at rest phosphorus-31 spectroscopy during high-dose atropine-dobutamine stress. Hypertensive showed higher mass...
Cardiac disease is the leading cause of mortality in type 2 diabetes mellitus (T2DM). Pioglitazone has been associated with improved cardiac outcome but also an elevated risk heart failure. We determined effects pioglitazone on myocardial function relation to high-energy phosphate, glucose, and fatty acid metabolism triglyceride content T2DM patients.Seventy-eight men without structural or inducible ischemia as assessed by dobutamine stress echocardiography were assigned (30 mg/d) metformin...
Purpose: The goal of this study was to evaluate a newly developed semiautomated contour detection algorithm for the quantitative analysis cardiovascular MRI. Method: Left ventricular function parameters derived from automatically detected endocardial and epicardial contours were compared with results manually traced in short-axis multislice GRE MRI studies 10 normal volunteers infarct patients. Results: Compared manual image analysis, method resulted following systematic random differences...
Magnetic resonance spectroscopy can quantify myocardial triglyceride content in type 2 diabetic patients. Its relation to alterations left (LV) and right (RV) ventricular functions is unknown.A total of 42 men with diabetes mellitus were recruited. Exclusion criteria included hemoglobin A(1c) >8.5, known cardiovascular disease, diabetes-related complications, or blood pressure >150/85 mm Hg. Myocardial ischemia was excluded by a negative dobutamine stress test. LV RV volumes ejection...