A5067431731- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiomyopathy and Myosin Studies
- Congenital Heart Disease Studies
- Advanced MRI Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Heart Failure Treatment and Management
- ECG Monitoring and Analysis
- Cardiovascular Effects of Exercise
- Congenital heart defects research
- Aortic Disease and Treatment Approaches
- Mesenchymal stem cell research
- Heart Rate Variability and Autonomic Control
- Cardiac Fibrosis and Remodeling
- Antiplatelet Therapy and Cardiovascular Diseases
Leiden University Medical Center
2015-2024
Leiden University
2015-2024
Consultative and Diagnostic Center
2022
Institute of Cardiology
2003-2020
Ghent University
2007-2018
Amsterdam UMC Location University of Amsterdam
2003-2017
Cleveland Clinic
2017
AZ Sint-Jan
2017
University of Amsterdam
2017
Netherlands Heart Institute
2000-2016
The ESC Guidelines represent the views of and were arrived at after careful consideration available evidence time they written.Health professionals are encouraged to take them fully into account when exercising their clinical judgement.The guidelines do not, however, override individual responsibility health make appropriate decisions in circumstances patients, consultation with that patient, where necessary patient's guardian or carer.It is also professional's verify rules regulations...
Guidelines and Expert Consensus Documents summarize evaluate all available evidence with the aim of assisting physicians in selecting best management strategy for an individual patient suffering from a given condition, taking into account impact on outcome risk–benefit ratio diagnostic or therapeutic means. are no substitutes textbooks their legal implications have been discussed previously. recommendations should help to make decisions daily practice. However, ultimate judgement regarding...
Guidelines summarize and evaluate all currently available evidence on a particular issue with the aim of assisting physicians in selecting best management strategy for an individual patient suffering from given condition, taking into account impact outcome, as well risk–benefit ratio diagnostic or therapeutic means. are no substitutes textbooks. The legal implications medical guidelines have been discussed previously. A large number issued recent years by European Society Cardiology (ESC)...
Currently, one third of patients treated with cardiac resynchronization therapy (CRT) do not respond. Nonresponse to CRT may be explained by the presence scar tissue in posterolateral left ventricular (LV) segments, which result ineffective LV pacing and inadequate resynchronization. In present study, relationship between transmural response was evaluated.Forty consecutive end-stage heart failure (NYHA class III/IV), ejection fraction < or =35%, QRS duration >120 ms, bundle-branch block,...
In patients with severe heart failure and dilated cardiomyopathy, cardiac resynchronization therapy (CRT) improves left ventricular (LV) systolic function associated LV reverse remodeling favorable 1-year survival. However, it is unknown whether translates into a better long-term prognosis what extent of clinically relevant, which were investigated in this study.Patients (n=141) advanced (mean+/-SD age, 64+/-11 years; 73% men) who received CRT followed up for mean (+/-SD) 695+/-491 days. The...
We calculated the wavelength of atrial impulse in chronically instrumented conscious dogs by measuring both conduction velocity and refractory period: = period X velocity. Implantation multiple stimulating recording electrodes allowed determination at four different areas: right left parts Bachmann's bundle free walls atria. During programmed electrical stimulation, three types arrhythmias were observed: rapid repetitive responses, flutter, fibrillation. normal rhythm, varied between 14 18...
The relation between infarct tissue heterogeneity on contrast-enhanced MRI and the occurrence of spontaneous ventricular arrhythmia (or sudden cardiac death) is unknown. Therefore, study purpose was to evaluate predictive value assessed with subsequent implantable cardioverter-defibrillator (ICD) therapy (as surrogate in patients previous myocardial infarction.Ninety-one (age, 65+/-11 years) infarction scheduled for ICD implantation underwent cine left function volumes characterization scar...
Aims At present, 20–30% of patients do not respond to cardiac resynchronization therapy (CRT). In this study, the relation between extent viable myocardium and scar tissue vs. response CRT was evaluated. addition, presence in left ventricular (LV) lead position specifically related CRT.
Background— 3D transesophageal echocardiography (TEE) may provide more accurate aortic annular and left ventricular outflow tract (LVOT) dimensions geometries compared with 2D TEE. We assessed agreements between TEE measurements multislice computed tomography (MSCT) changes in annular/LVOT areas after transcatheter valve implantations (TAVI). Methods Results— Two-dimensional circular (π� r 2 ), circular, planimetered LVOT by were “gold standard” MSCT before TAVI. Mean area was 4.65�0.82 cm...
During persistent atrial fibrillation (AF), waves with a focal spread of activation are frequently observed. The origin these and their relevance for the persistence AF unknown.In 24 patients longstanding structural heart disease, high-density mapping right left atria was performed during cardiac surgery. In reference group 25 patients, induced by rapid pacing. For data analysis, algorithm developed that separated fibrillatory process into its individual wavelets identified origin. AF,...
Catheter ablation of ventricular tachycardia (VT) after repair congenital heart disease can be difficult because nonmappable VTs and complex anatomy. Insights into the relation between anatomic isthmuses identified by delineating unexcitable tissue using substrate mapping techniques critical reentry circuit might facilitate ablation.Sinus rhythm voltage right ventricle was performed in 11 patients with sustained VT disease. Unexcitable from patch material, valve annulus, or dense fibrosis,...
Cardiac resynchronization therapy (CRT) is now a well-recognized therapeutic option for patients with end-stage heart failure. However, not all respond to CRT, and, therefore, preimplantation identification of responders desirable. The aim the present study was investigate whether degree left ventricular (LV) dyssynchrony, as assessed phase analysis from gated myocardial perfusion SPECT (GMPS), can predict which will CRT. <b>Methods:</b> Forty-two severe failure, depressed LV ejection...