A5032349035- Atherosclerosis and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cytomegalovirus and herpesvirus research
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- Venous Thromboembolism Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Adipokines, Inflammation, and Metabolic Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Long-Term Effects of COVID-19
- Marriage and Sexual Relationships
- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Coronary Interventions and Diagnostics
- Cardiovascular Disease and Adiposity
- Anesthesia and Neurotoxicity Research
- Chemokine receptors and signaling
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Immune cells in cancer
Moscow State University of Medicine and Dentistry
2014-2023
City Clinical Hospital
2020-2022
Ministry of Health of the Russian Federation
2017-2021
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2011-2016
Institute of Surgery named after A. V. Vishnevskogo
2016
National Institutes of Health
2016
Pulmonary and Critical Care Associates
2011-2015
Arizona Oncology
2011-2015
Oregon Dermatology & Research Center
2011-2015
Amherst College
2011-2015
The ESC Guidelines represent the views of and were arrived at after careful consideration available evidence time they written.Health professionals are encouraged to take them fully into account when exercising their clinical judgement.The guidelines do not, however, override individual responsibility health make appropriate decisions in circumstances patients, consultation with that patient, where necessary patient's guardian or carer.It is also professional's verify rules regulations...
Guidelines summarize and evaluate all currently available evidence on a particular issue with the aim of assisting physicians in selecting best management strategy for an individual patient suffering from given condition, taking into account impact outcome, as well risk–benefit ratio diagnostic or therapeutic means. are no substitutes textbooks. The legal implications medical guidelines have been discussed previously. A large number issued recent years by European Society Cardiology (ESC)...
Russian Society of Cardiology (RSC). With the participation Scientific Clinical Electrophysiology, Arrhythmology and Cardiac Pacing, Association Cardiovascular Surgeons. Approved by Practical Council Ministry Health.
To decipher the immunologic mechanisms of plaque maturation and rupture, it is necessary to analyze phenotypes distribution individual lymphocytes that migrate plaques, as well their activation at different stages formation.
Although an association between human herpesvirus (HHV) infection and atherosclerosis has been suggested, the data supporting such are controversial and, in most cases, based on serological evidence or presence of cell-associated HHV DNA, which do not report about actual viral replication. We quantified DNA all 8 types HHVs plasma, their is replication.Using quantitative real-time polymerase chain reaction, we evaluated blood samples obtained at time hospitalization from 71 patients with...
During the ongoing coronavirus disease 2019 (COVID-19) pandemic, many individuals were infected with and have cleared virus, developing virus-specific antibodies effector/memory T cells. An important unanswered question is what levels of T-cell antibody responses are sufficient to protect from infection.
The level of systemic inflammation correlates with the severity clinical course acute myocardial infarction (AMI). It has been shown that circulating cytokines and endothelial dysfunction play an important role in process clot formation. aim our study was to assess concentration various cytokines, function blood clotting AMI patients depending on flow through infarction-related artery (IRA).We included 75 AMI. 58 presented ST-elevation (STEMI) 17 had non-ST-elevation (non-STEMI). A...
The novel coronavirus infection COVID-19 in most cases manifests with respiratory symptoms and fever, however, some patients may have cardiovascular gastroenterological manifestations. A feature of the clinical syndrome is development pronounced immunopathological reactions disorders hemostasis, leading to a wide range complications. course be complicated by acute myocardial infarction, venous arterial thrombosis thromboembolism various vascular pools, damage myocarditis. Among...
Abstract Acute myocardial infarction (AMI) is associated with activation of various cells, including platelets that form monocyte–platelet complexes (MPCs). Here, we analysed MPC in vivo and vitro investigated the abilities different monocyte subclasses to MPC, characteristics cells involved formation changes AMI. We identified by co-staining for platelet antigen CD41a antigens CD14 CD16. Platelet was evaluated from expression phosphatidylserine as revealed annexin V. Our results confirm...
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A diverse population of small extracellular vesicles (EVs) that are released by various cells has been characterized predominantly in bulk, a procedure whereby the individual characteristics EVs lost. Here, we used new nanotechnology-based flow cytometric analysis to characterize antigenic composition patients with acute coronary syndrome (ACS). Plasma were captured 15-nm magnetic nanoparticles coupled antibodies against CD31 (predominantly an endothelial marker), CD41a (a marker for...
An association between productive cytomegalovirus infection and atherosclerosis was shown recently in several trials, including a previous study of ours. However, the mechanism involved this is still under investigation. Here, we addressed interaction endothelial function patients with ST-elevation myocardial infarction (STEMI).We analyzed presence cytomegaloviral DNA plasma 33 STEMI volunteers without cardiovascular diseases, using real-time polymerase chain reaction (PCR) noninvasive test...
A proinflammatory dysregulation of cytokine release is associated with various diseases, in particular those infectious etiology, as well cardiovascular diseases (CVD). We showed earlier that cytokines are released two forms, soluble and association extracellular vesicles (EVs). Here, we investigated the patterns expression clustering EV-associated patients ST-elevation myocardial infarction (STEMI). collected plasma samples from 48 volunteers without CVD 62 STEMI, separated EV fractions,...
The relationship between acute coronary syndrome (ACS) and local systemic inflammation, including accumulation of macrophages in atherosclerotic plaques upregulation blood cytokines (e.g., C-reactive protein (CRP)), has been known for more than 100 years. atherosclerosis-associated inflammatory response traditionally considered as an immune system reaction to low-density lipoproteins. At the same time, some data have indicated a potential involvement cytomegalovirus (CMV) activation...
Aim. Cryoballoon ablation (CBA) is one of the methods for catheter pulmonary vein isolation (PVI) paroxysmal atrial fibrillation (AF). Left additional lesion (LAAL) to PVI were proposed eliminate extrapulmonary AF triggers. Nonetheless whether lesions improve CBA effectiveness not clear. Methods. Primary procedures performed during 2017-2021 analyzed. The study group (Algorithm group, n=82) was recruited prospectively in 2019-2021. As first step all pts. In those who on sinus rhythm (SR)...
Objective : to assess results from the Stroke Network created on basis of Infarction in metropolis Moscow for endovascular treatment patients with occlusion large cerebral artery (the internal carotid artery, M1 and M2 segments middle main artery). Patients methods . A total 742 thromboextractions were performed ischemic stroke hospitals 2019. The final analysis included 729 aged 25 97 years (mean age, 71 years); them there 370 (50.8%) men 359 (49.2%) women. selection criteria consistent...
Summary Rapid spread of COVID-19 pandemic made a substantial share the world population immunised by SARS-CoV-2 antigens. Infection induces development virus-specific antibodies and T cells. Ample evidence on antibody-mediated protection is contrasted elusive role cells in preventing infection. To explore impact to quantify protective levels immune responses we conducted large prospective study: 5,340 Moscow residents were evaluated for antibody cellular monitored up 300 days. The tightly...
Background: Occlusion of the coronary artery is main cause ST-elevation myocardial infarction (STEMI). In some patients, it followed by early spontaneous thrombolysis. this study, we tried to determine whether thrombolysis in infarct-related (IRA) correlates with state endothelium, which assessed using brachial flow-mediated dilation (FMD) test. Methods: 52 patients STEMI were included study. Based on results angiography performed during first three days STEMI, divided into two groups: Group...