A5056005213- Atherosclerosis and Cardiovascular Diseases
- Cytomegalovirus and herpesvirus research
- Extracellular vesicles in disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Human Health and Disease
- Herpesvirus Infections and Treatments
- Systemic Lupus Erythematosus Research
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Chemokine receptors and signaling
- Acute Myocardial Infarction Research
- Healthcare Systems and Public Health
- Cardiac Imaging and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Obesity, Physical Activity, Diet
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Nutrition, Genetics, and Disease
- Venous Thromboembolism Diagnosis and Management
- Cardiac Ischemia and Reperfusion
- Blood Pressure and Hypertension Studies
- Biomarkers in Disease Mechanisms
- Immune cells in cancer
- Bariatric Surgery and Outcomes
Universitätsmedizin Greifswald
2025
German Centre for Cardiovascular Research
2025
Federal Research Centre of Nutrition and Biotechnology
2023
TU Dresden
2023
Moscow State University of Medicine and Dentistry
2013-2022
Pirogov Russian National Research Medical University
2019-2022
Lomonosov Moscow State University
2020
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2016-2018
National Institutes of Health
2016-2018
Ministry of Health of the Russian Federation
2018
Abstract Prevention of cardiovascular disease (CVD) remains one the largest public health challenges our time. Identifying individuals at increased risk an asymptomatic, sub-clinical stage is paramount importance for minimizing progression as well substantial and economic burden associated with overt CVD. Vascular ageing (VA) involves deterioration in vascular structure function over time ultimately leads to damage heart, brain, kidney, other organs. encompasses cumulative effect all factors...
Although an association between human herpesvirus (HHV) infection and atherosclerosis has been suggested, the data supporting such are controversial and, in most cases, based on serological evidence or presence of cell-associated HHV DNA, which do not report about actual viral replication. We quantified DNA all 8 types HHVs plasma, their is replication.Using quantitative real-time polymerase chain reaction, we evaluated blood samples obtained at time hospitalization from 71 patients with...
The level of systemic inflammation correlates with the severity clinical course acute myocardial infarction (AMI). It has been shown that circulating cytokines and endothelial dysfunction play an important role in process clot formation. aim our study was to assess concentration various cytokines, function blood clotting AMI patients depending on flow through infarction-related artery (IRA).We included 75 AMI. 58 presented ST-elevation (STEMI) 17 had non-ST-elevation (non-STEMI). A...
Extracellular vesicles (EVs) released by virus-infected cells typically incorporate host and viral components inside the (cargo molecules). Here, we investigated if human cytomegalovirus (HCMV) proteins are incorporated in EV outer membrane HCMV-infected cells. We separated EVs from HCMV using an iodixanol step-gradient found that carried markers such as tetraspanin CD63 Rab27A. Flow analysis of individual demonstrated on average, 15 ± 3.7% were positive for gB, 5.3 2.3% gH 3.74 1.5% both gB...
Abstract Cytotoxic CD4 T cells are linked to cardiovascular morbidities and accumulate in both HIV CMV infections, of which associated with increased risk disease (CVD). In this study, we identify coinfection as a major driver the cytotoxic phenotype, characterized by elevated CD57 expression reduced CD28 expression, circulating from people living infection, investigate potential mechanisms linking cell population CVD. We find that human CD57+ express high levels costimulatory receptor CD2...
Atherosclerotic cardiovascular disease (ASCVD) remains an important cause of morbidity in the general population and risk for ASCVD is increased approximately 2-fold persons living with HIV infection (PLWH). This linked to elevated CD8 T cell counts that are abundant atherosclerotic plaques have been implicated pathogenesis yet mechanisms driving recruitment activation within poorly defined. Here we investigated role cells atherosclerosis a non-human primate model HIV-uninfected elderly;...
A diverse population of small extracellular vesicles (EVs) that are released by various cells has been characterized predominantly in bulk, a procedure whereby the individual characteristics EVs lost. Here, we used new nanotechnology-based flow cytometric analysis to characterize antigenic composition patients with acute coronary syndrome (ACS). Plasma were captured 15-nm magnetic nanoparticles coupled antibodies against CD31 (predominantly an endothelial marker), CD41a (a marker for...
An association between productive cytomegalovirus infection and atherosclerosis was shown recently in several trials, including a previous study of ours. However, the mechanism involved this is still under investigation. Here, we addressed interaction endothelial function patients with ST-elevation myocardial infarction (STEMI).We analyzed presence cytomegaloviral DNA plasma 33 STEMI volunteers without cardiovascular diseases, using real-time polymerase chain reaction (PCR) noninvasive test...
A proinflammatory dysregulation of cytokine release is associated with various diseases, in particular those infectious etiology, as well cardiovascular diseases (CVD). We showed earlier that cytokines are released two forms, soluble and association extracellular vesicles (EVs). Here, we investigated the patterns expression clustering EV-associated patients ST-elevation myocardial infarction (STEMI). collected plasma samples from 48 volunteers without CVD 62 STEMI, separated EV fractions,...
The relationship between acute coronary syndrome (ACS) and local systemic inflammation, including accumulation of macrophages in atherosclerotic plaques upregulation blood cytokines (e.g., C-reactive protein (CRP)), has been known for more than 100 years. atherosclerosis-associated inflammatory response traditionally considered as an immune system reaction to low-density lipoproteins. At the same time, some data have indicated a potential involvement cytomegalovirus (CMV) activation...
Coronavirus disease 2019 (COVID-19) is characterized by immune activation in response to viral spread, severe cases leading the development of cytokine storm syndrome (CSS) and increased mortality. Despite its importance prognosis, pathophysiological mechanisms CSS COVID-19 remain be defined. Towards this goal, we analyzed profiles their interrelation regard anti-cytokine treatment with tocilizumab 98 hospitalized patients COVID-19. We performed a multiplex measurement 41 circulating...
The article presents the results of 13-year monitoring epidemiological studies on actual nutrition and eating habits among children adolescents studying in educational institutions Republic Sakha (Yakutia). study used standardized questionnaires, adapted by Nutrition Center Health Institute M.K. Ammosov North-Eastern Federal University, accordance with national traditions food culture peoples North Arctic. Methods frequency analysis consumption individual products daily reproduction from...
1 ФГБОУ ВО «Московский государственный медико-стоматологический университет им.А. И. Евдокимова» Минздрава России, Москва 2 Национальный Институт Детского Здоровья и Развития Человека им
Aim of the study - to assess effect remote ischemic preconditioning (RIPC) on incidence endothelial dysfunction (ED) and its impact hospital prognosis in patients with ST segment elevation acute myocardial infarction (STEMI). Materials methods. We conducted a single centre, open label prospective that included 173 STEMI who underwent primary percutaneous coronary intervention within first 24 hours symptoms onset. Before PCI, were randomized into two groups. In group (n=86) during preparation...