A5059242487- COVID-19 Clinical Research Studies
- Acute Myocardial Infarction Research
- Adipokines, Inflammation, and Metabolic Diseases
- Long-Term Effects of COVID-19
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood properties and coagulation
- Venous Thromboembolism Diagnosis and Management
- COVID-19 and healthcare impacts
- SARS-CoV-2 and COVID-19 Research
- Mechanical Circulatory Support Devices
- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Atherosclerosis and Cardiovascular Diseases
- Cardiac electrophysiology and arrhythmias
- Biomarkers in Disease Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Climate Change and Health Impacts
- Ultrasound and Hyperthermia Applications
- Coronary Interventions and Diagnostics
- Neurological Disorders and Treatments
- Ultrasound in Clinical Applications
- Poisoning and overdose treatments
City Clinical Hospital No. 2
2025
City Clinical Hospital
2022-2024
Moscow State University of Medicine and Dentistry
2020-2023
Ministry of Health of the Russian Federation
2021
The level of systemic inflammation correlates with the severity clinical course acute myocardial infarction (AMI). It has been shown that circulating cytokines and endothelial dysfunction play an important role in process clot formation. aim our study was to assess concentration various cytokines, function blood clotting AMI patients depending on flow through infarction-related artery (IRA).We included 75 AMI. 58 presented ST-elevation (STEMI) 17 had non-ST-elevation (non-STEMI). A...
Introduction: Critically ill COVID-19 patients receiving prophylactic-dose antico-agulation exhibit high rates of thrombosis and mortality. Escalation anticoagu-lation also does not reduce mortality has an uncertain impact on the throm-bosis rates. The reasons why escalated doses fail to outperform prophylactic in reducing risks death critically remain unclear. We hypothesized that anticoagulation would ef-fectively prevent plasma hypercoagulability and, consequently, risk some patients....
Introduction: Severely ill COVID-19 patients receiving prophylactic-dose anticoagulation exhibit high rates of thrombosis and mortality. The escalation also does not reduce mortality has an uncertain impact on rates. reasons why escalated doses fail to outperform prophylactic in reducing risks death severely remain unclear. We hypothesized that would effectively prevent hypercoagulability and, consequently, the risk some patients. Methods: conducted a prospective multicenter study enrolled...
The molecular mechanisms underlying cardiovascular complications after the SARS-CoV-2 infection remain unknown. goal of our study was to analyze features blood coagulation, platelet aggregation, and plasma proteomics in COVID-19 convalescents with AMI. included 66 AMI patients 58 healthy volunteers. groups were divided according anti-N IgG levels (AMI post-COVID (n = 44), control 22), 31), 27)). All participants underwent rotational thromboelastometry, thrombodynamics, impedance...
Acute toxic myocardial damage may be accompanied by the development of cardiogenic shock (CS), mortality from which is still unacceptably high. Since there no specific antidote for many types toxins, treatment such patients includes various measures hemodynamic and respiratory support. The paper presents a case refractory CS due to possible aluminum phosphide (AP) poisoning.A 20-year-old man was admitted emergency department 4 days after home inhalation AP complaints nausea, vomiting,...
Abstract With the progress of COVID-19 studies, it became evident that SARS-CoV-2 infection is often associated with thrombotic complications. The goal our present study was to evaluate which component clot formation process including endothelial function, platelets aggregation and plasma coagulation, as well endogenous fibrinolysis in patients correlates severity disease. We prospectively included 58 47 healthy volunteers a control group we recruited before pandemic started. It turns out...
Coronavirus disease 2019 (COVID-19) is characterized by immune activation in response to viral spread, severe cases leading the development of cytokine storm syndrome (CSS) and increased mortality. Despite its importance prognosis, pathophysiological mechanisms CSS COVID-19 remain be defined. Towards this goal, we analyzed profiles their interrelation regard anti-cytokine treatment with tocilizumab 98 hospitalized patients COVID-19. We performed a multiplex measurement 41 circulating...
Aim . To identify the features of plasma, platelet hemostasis, and proteomic composition blood plasma in patients with acute myocardial infarction (AMI) healthy volunteers after COVID-19. Material methods The study included AMI who have recently had COVID-19 (AMI-post-COVID, n=56) not (AMI-control, n=141). Healthy constituted control groups were also divided into control-post-COVID (n=32) control-control (n=71) groups. Previous SARS-CoV-2 infection was determined by anti-N IgG serum, level...
Цель. Оценка взаимосвязи тяжести течения COVID-19 у пациентов без исходной сердечно-сосудистой патологии с различными эхокардиографическими параметрами дисфункции миокарда обоих желудочков.
Abstract Background/Introduction There are numerous reports regarding the direct endothelial damage by SARS-CoV-2 that can lead to activation of both plasma hemostasis and platelet aggregation. However, mechanism interaction between endothelium haemostasis in COVID-19 remains unclear. Purpose The aim our study was assess relationship each link clot formation process (endothelial function, coagulation, aggregation) with severity disease. Methods 58 patients were included study. Patients...
Abstract Introduction Enhanced activation of endogenous fibrinolysis in ST-elevation myocardial infarction (STEMI) patients is the main cause spontaneous reperfusion infarct-related artery (IRA) acute period. Whether this enhanced remains deferred period unclear. Purpose The purpose our work was to analyze process clot formation and with a history infarction. Methods We included 51 (median, 35 months). Of these patients, 19 had IRA (SR group) during index event, 32 total occlusion (occlusion...
A 45-year-old female patient with a previous SARS-CoV2 pneumonia suddenly presented pain, swelling and cyanosis of the left leg, severe dyspnea.Extensive deep vein thrombosis leg bilateral pulmonary embolism were diagnosed.The received standard treatment according to ESC 2019 Guidelines on Acute Pulmonary Embolism (Konstantinides et al., 2019).A study patient's cytokine profile was carried out, which an increase in several pro-inflammatory cytokines detected.After 3-week follow-up, partial...
Aim. Analysis of the dynamics different stages clot formation and its lysis in patients with COVID-19 severity. Materials methods. We prospectively included 58 (39 moderate disease severity 18 severe disease) 47 healthy volunteers as a control group. All participants underwent assessment flow-mediated dilation (FMD) brachial artery, impedance aggregometry, rotational thromboelastometry thrombodynamics. Von Willebrand factor antigen (vWF:Ag) quantification was also performed COVID-19....
Abstract Introduction Coagulopathy plays a significant role in COVID-19 pathogenesis. Benefit from anticoagulation is well established hospitalized patients. But since there lack of data on coagulopathy resolution: no consensus guidelines if extended required. Purpose The purpose our work was to analyze coagulation abnormalities at 2 5 months after moderate severe COVID-19. Methods reconvalescents (CR), discharged hospital, were called for follow-up 2–3 (CR1 group, 21 patients) or 5–6 (CR2...
Abstract Background/Introduction SARS-CoV-2 is notorious for its ability to cause damage the respiratory system and myocardium, which can result in development of acute distress syndrome myocardial dysfunction. Purpose The aim our study was assess interaction between severity COVID-19 echocardiographic parameters dysfunction, as well lung ultrasound data. Methods 47 patients without signs cardiovascular pathology were included (33 moderate subgroup 14 severe subgroup). All underwent...