A5086743562- MicroRNA in disease regulation
- Circular RNAs in diseases
- Extracellular vesicles in disease
- COVID-19 Clinical Research Studies
- Anodic Oxide Films and Nanostructures
- Long-Term Effects of COVID-19
- Cancer-related molecular mechanisms research
- Biomarkers in Disease Mechanisms
- Aortic aneurysm repair treatments
- Technology and Human Factors in Education and Health
- Adipokines, Inflammation, and Metabolic Diseases
- IL-33, ST2, and ILC Pathways
- RNA Research and Splicing
- Healthcare Systems and Public Health
- Cardiovascular Disease and Adiposity
- COVID-19 and healthcare impacts
- Viral gastroenteritis research and epidemiology
- Aortic Disease and Treatment Approaches
- Immune Cell Function and Interaction
Sechenov University
2018-2024
City Clinical Hospital
2024
Moscow State University of Medicine and Dentistry
2020-2021
Extracellular circulating microRNAs (miRNAs) are currently a focus of interest as non-invasive biomarkers cardiovascular pathologies, including coronary artery disease (CAD) and acute syndromes (ACS): myocardial infarction with without ST-segment elevation (STEMI NSTEMI) unstable angina (UA). However, the current data for some miRNAs controversial inconsistent, probably due to pre-analytical methodological variances in different studies. In this work, we fulfilled basic requirements provided...
The potential of extracellular circulating microRNAs (miRNAs) as non-invasive biomarkers atrial fibrillation (AF) has been confirmed by a number recent studies. However, the current data for some miRNAs are controversial and inconsistent, probably due to pre-analytical methodological differences. In this work, we attempted fulfill basic requirements provided miRNA studies application paroxysmal (PAF) research. We used quantitative PCR (qPCR) determine relative plasma levels expressed in...
Microfold cells (M cells) are specialized intestinal epithelial that initiate mucosal immune responses. These unique phagocytic for the transfer of a broad range particulate antigens and microorganisms across follicle-associated epithelium (FAE) into gut-associated lymphoid tissue (GALT) by process termed transcytosis. The molecular basis antigen uptake M has been gradually identified in last decade. Active sampling initiates regulated responses ensure homeostasis. delivery luminal...
Abstract With the progress of COVID-19 studies, it became evident that SARS-CoV-2 infection is often associated with thrombotic complications. The goal our present study was to evaluate which component clot formation process including endothelial function, platelets aggregation and plasma coagulation, as well endogenous fibrinolysis in patients correlates severity disease. We prospectively included 58 47 healthy volunteers a control group we recruited before pandemic started. It turns out...
Aim . To compare the relative expression levels of circulating microRNAs associated with cardiovascular diseases, selected according to literature review, in blood plasma samples patients two variants chronic vascular wall injury: coronary artery atherosclerosis (CAA) and thoracic aortic aneurysm (TAA). Material methods Patients admitted Clinical Center I. M. Sechenov First Moscow State Medical University (University Hospital No. 1) CAA (n=45), TAA (n=38), as well a control group (n=17) were...
Background: Circulating extracellular platelet-derived microRNAs have been actively studied over the last decade as promising biomarkers of cardiovascular disease (CVD), since platelet activation plays a key role in pathogenesis CVD. The aim study: To compare microRNA profiles patients with uncomplicated hypertension (HT) and HT acute myocardial infarction ST-segment elevation (STEMI). Materials methods: study included 20 15 STEMI. At least 90% participants each group received antiplatelet...
Aim. To study the plasma profiles of circulating extracellular microribonucleic acids (miRNAs), potentially including in pathogenesis cardiovascular diseases, patients with atrial fibrillation (AF) combination hypertension (HTN) or coronary artery disease (CAD). Material and methods . The included AF combi nation HTN (n=21) CAD (n=10), as well following control groups: uncomplicated without (n=28), stable (n=10) healthy individuals (n=30). MiRNA samples were isolated from blood participants....
Abstract Background/Introduction There are numerous reports regarding the direct endothelial damage by SARS-CoV-2 that can lead to activation of both plasma hemostasis and platelet aggregation. However, mechanism interaction between endothelium haemostasis in COVID-19 remains unclear. Purpose The aim our study was assess relationship each link clot formation process (endothelial function, coagulation, aggregation) with severity disease. Methods 58 patients were included study. Patients...