A5032080330- Spaceflight effects on biology
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Stress Responses and Cortisol
- Human Health and Disease
- Hepatitis C virus research
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Optical Imaging and Spectroscopy Techniques
- Liver Disease Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Medical and Biological Sciences
- Mitochondrial Function and Pathology
- S100 Proteins and Annexins
- Neurological Disorders and Treatments
- Muscle Physiology and Disorders
- Health and Medical Research Impacts
- Contact Dermatitis and Allergies
- Thermoregulation and physiological responses
- Cancer Cells and Metastasis
- High Altitude and Hypoxia
- Anesthesia and Neurotoxicity Research
- Optical Polarization and Ellipsometry
- Dermatology and Skin Diseases
Sechenov University
2014-2024
Lomonosov Moscow State University
2011-2023
Frumkin Institute of Physical Chemistry and Electrochemistry
2012-2014
Russian Academy of Sciences
2012-2013
University of Rhode Island
2008-2012
Academy of Medical Sciences
2012
Ministry of Health of the Russian Federation
2009
University of Virginia
2008
Progress in nanomedicine depends on the development of nanomaterials and targeted delivery methods. In this work, we describe a method for preferential targeting gold nanoparticles to tumor mouse model. The is based use pH Low Insertion Peptide (pHLIP), which targets various imaging agents acidic tumors. We compare by nonfunctionalized nanogold particles with nanogold–pHLIP conjugates, where covalently attached N terminus pHLIP. Our most important finding that both intratumoral i.v....
Abstract Prostate cancer is the second most common globally in men, and some countries now diagnosed form of cancer. It necessary to differentiate between benign malignant prostate conditions give accurate diagnoses. We aim demonstrate use a 3D Mueller matrix method allow quick easy clinical differentiation adenoma carcinoma tissues with different grades Gleason scores. Histological sections tumours, obtained by radical prostatectomy, were investigated. map degree depolarisation tumour using...
Abstract The impairments of cerebral blood flow microcirculation brought on by cardiac and respiratory arrest were assessed with multi‐modal diagnostic facilities, utilising laser speckle contrast imaging, fluorescence spectroscopy diffuse reflectance spectroscopy. results imaging show a notable reduction in small medium size vessels during few minutes arrest, while the same effect was observed large sinuses their branches circulatory cessation. Concurrently, redox ratio indicates...
Diseases affecting myocardial tissues are currently a leading cause of death in developed nations. Fast and reliable techniques for analysing understanding how affected by disease respond to treatment fundamental combating the effects heart disease. A 3D Mueller matrix method that reconstructs linear circular birefringence dichroism parameters has been image biological structures tissues. The required optical data is gathered using Stokes polarimeter then processed mathematically recover...
In this work, we apply generative topographic maps as a universal approach for data visualization and structure–property modeling of melting points (mp), which is one the most important physical properties design application ionic liquids (ILs) green solvents. Data part more general concept chemography, relatively new field dealing with chemical data, representation space, navigation in space. This has received much attention by chemists it may help to analyze intuitively comprehend relevant...
HERG potassium channels have a critical role in the normal electrical activity of heart. The blockade hERG heart cells can result potentially fatal disorder called long QT syndrome. be blocked by compounds with diverse structures belonging to several drug classes. Presented herein are generative (Generative Topographic Maps) and discriminative (Support Vector Machines) classification models categorize silico into active inactive classes using different types descriptors. predictive...
Acute cerebral circulation disorder is one of the most discussed issues in modern intensive care and neurology, as it a severe condition, leading to disability or death patient, absence immediate medical care. This review discusses general specific biological markers stroke, genetic current data on their diagnostic significance. The main mechanisms brain tissue cell such apoptosis, necrosis, ferroptosis, parthanatosis, sarmoptosis, autolysis, autophagy, oncosis, excitotoxic are analyzed;...
Journal Article Lambek grammars with one division and primitive type Get access Stepan Kuznetsov * Moscow State University, Moscow, Russia E-mail: skuzn@inbox.ru Search for other works by this author on: Oxford Academic Google Scholar Logic of the IGPL, Volume 20, Issue 1, February 2012, Pages 207–221, https://doi.org/10.1093/jigpal/jzr031 Published: 09 August 2011 history Received: 13 October 2010
Background NORE1A and RASSF1A are growth tumour suppressors inactivated in a variety of cancers. Methylation promoters is the predominant mechanism for downregulation these proteins; however, other mechanisms likely to exist. Methodology/Principal Findings Here we describe proteolysis by calpains as alternative their downregulation. Extracts H358 cell line, human bronchoalveolar carcinoma, H460, large were capable protein calpain-dependent manner. Likewise, tumor suppressor was proteolyzed...
The NORE1 protein was identified in a yeast two-hybrid screen as Ras effector that binds GTP-dependent manner. NORE1A is growth and tumour suppressor inactivated variety of cancers. In transformed human cells, both full-length its domain alone (amino acids 191-363) are localized to microtubules centrosomes. However, the mechanism by which associates with these cytoskeletal elements not known; furthermore, whether centrosomally-associated or microtubule-associated suppresses cell has been yet...
Despite a rapid growth in the application of modern techniques for visualization studies life sciences, classical methods histological examination are yet to be outdated. Herein, we introduce new approach that involves combining silver nitrate pretreatment and impregnation with consequent Nissl (cresyl violet) staining cortex striatum architectonics study on same microscopy slide. The developed hybrid provides high-quality cellular subcellular structures, including impregnated neurons (about...
Aim . We sought to assess the effects of exogenous Hsp70 (single subcutaneous low- and high-dose injections) on organ structure functions in adult mice. Materials methods randomized CD1 90-day-old male mice ( n = 30) three groups (10 per group). injected animals with single saline solution for Group 1 (control), low dose (500 μg/kg) recombinant human (HspA1A) 2, high (5000 3. examined behavior Day 3 after injections (distance traveled, velocity, bowel movement number). lethalized 5 further...
Microfold cells (M cells) are specialized intestinal epithelial that initiate mucosal immune responses. These unique phagocytic for the transfer of a broad range particulate antigens and microorganisms across follicle-associated epithelium (FAE) into gut-associated lymphoid tissue (GALT) by process termed transcytosis. The molecular basis antigen uptake M has been gradually identified in last decade. Active sampling initiates regulated responses ensure homeostasis. delivery luminal...
We consider language models for the Lambek calculus that allow empty antecedents and enrich them with constants containing only word. No complete calculi are known respect to these semantics, in this paper we several trivalent systems arise as fragments of models' logics.
Fine needle aspiration biopsy technique and following histological examination show its effectiveness safety but performing takes several time. However, the problem of real-time analysis pathological changes in tissues remains relevant. We demonstrate optical fine-needle method, combining a fine (17.5G) fiber-optic probe (1 mm diameter) for minimally invasive interrogation tissue vivo. During rat tumor experiment, we collected spectrally-resolved diffuse reflectance fluorescence. Quantified...
Anthropogenic activity causes the introduction of zinc compounds into biological cycle in mining and processing sites its accumulation organs tissues, causing systemic toxicity. A cumulative effect is predominantly neurotoxic it also affects respiratory, cardiovascular digestive systems. This study evaluates effects single-dose intragastric administration 100 mg/kg succinate on structure function tissues male Wistar rats 1 month after treatment. The presented morphofunctional approach for...