A5005575645- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Immune Response and Inflammation
- Nanoparticle-Based Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Graphene and Nanomaterials Applications
- Thermal Regulation in Medicine
- Microplastics and Plastic Pollution
- Neuroscience of respiration and sleep
- Stress Responses and Cortisol
- RNA modifications and cancer
- Eicosanoids and Hypertension Pharmacology
- Thermoregulation and physiological responses
- Cancer Cells and Metastasis
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Iron Metabolism and Disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- interferon and immune responses
- Circadian rhythm and melatonin
- Characterization and Applications of Magnetic Nanoparticles
- Exercise and Physiological Responses
- Liver Disease Diagnosis and Treatment
Research Institute of Human Morphology
2017-2025
Peoples' Friendship University of Russia
2022-2025
Russian Scientific Center of Surgery
2024
All-Russian Scientific Research Institute of Irrigation and Agricultural Water Supply "Raduga"
2021
The substituent's Hammett parameter correlates linearly with electrochemical reduction potentials and rates of hypoxia-activated dissociation cobalt complexes esculetin.
Background One of the effective strategies for treatment tumor diseases, including colitis-associated colorectal cancer (CAC), is immunotherapy. During inflammation, NF-κB activated, which connected with hypoxia-inducible factor—HIF, regulating immune cells functioning and influences CAC development. Organisms differ according to their hypoxia resistance HIF expression. Therefore, aim study was characterize thymus, spleen mesenteric lymph nodes morphofunctional features, as well changes in...
The aim of the study was to characterize severity systemic inflammatory response induced by lipopolysaccharide (LPS) in animals with different resistance levels hypoxia.Two three months old male Wistar rats (220-240 g) were divided according hypoxia tolerance a hypobaric chamber. After month, they injected intraperitoneally Escherichia coli LPS at dose 1.5 mg/kg. 3, 6 and 24 hours injection, we studied IL-1β, C-reactive protein (CRP) TGF-β serum, expression Hif-1α Nf-kb liver, morphological...
Microplastic pollution poses a threat to human health. It is possible that the increase in incidence of inflammatory bowel disease associated with exposure microplastics. We investigated effect consumption polystyrene microparticles diameter 5 μm at dose 2.3 mg/kg/day for 6 weeks on morphological changes colons healthy male C57BL/6 mice and acute colitis induced by 1% dextran sulfate sodium solution (DSS). In mice, microplastics caused an number endocrine cells, content highly sulfated...
Magnetic nanoparticles are widely used in biomedicine for MRI imaging and anemia treatment. The aging of these nanomaterials vivo may lead to gradual diminishing their contrast properties inducing toxicity. Here, we describe observation the full lifecycle 40-nm magnetic particles from injection complete degradation associated impact on organism. We found that 2 h were eliminated bloodstream, but initial biodistribution changed over time. In 1 week, a major part was transferred liver spleen,...
Hypoxia is a major pathogenetic factor in many cancers. Individual resistance to suboptimal oxygen availability subject broad variation and its possible role tumorigenesis remains underexplored. This study aimed at specific characterization of glioblastoma progression male tolerant susceptible hypoxia Wistar rats. was assessed by gasping time measurement an 11,500 m altitude-equivalent hypobaric decompression chamber. Based on the outcome, animals were assigned three groups termed 'tolerant...
Individual hypoxia tolerance is a major influence on the course and outcome of infectious inflammatory diseases. Macrophages, which play central roles in systemic response other immunity reactions, are subject to functional activation orchestrated by several transcription factors including inducible (HIFs). HIF-1 expression levels lipopolysaccharide (LPS)-induced severity have been shown correlate with tolerance. Molecular features macrophages, depending organisms resistance hypoxia, can...
Soft tissue sarcomas (STSs) are a rare heterogeneous group of malignant neoplasms characterized by their aggressive course and poor response to treatment. This determines the relevance research aimed at studying pathogenesis STSs. By now, it is known that STSs complex relationships between tumor cells immune microenvironment. Dynamic interactions components microenvironment enhance adaptation changing environmental conditions, which provides high potential resistance antitumor therapy....
Abstract It is a common fact, that the content of sex hormones in humans and animals varies different age periods. The functional state immune system also changes with age. However, differences studies inflammatory responses during puberty prevail literature. Investigation to LPS peculiarities prepubertal females males may contribute development more effective immunotherapy minimize side effects children vaccination. Therefore, aim this work was investigate LPS-induced SIRS Wistar rats....
Hypoxia is connected with inflammation, and the severity of inflammatory diseases predominantly depends on individual tolerance to oxygen deficiency. Hypoxia-inducible factor, HIF-1, regulates thymus functional state, its activity varies in organisms different hypoxia tolerance. It likely that differences associated HIF-1 may influence severity, such as acute chronic ulcerative colitis. The study aim characterize morphological changes during colitis animals male C57Bl/6 mice was determined...
On the model of systemic inflammatory response (SIRS), induced by lipopolysaccharide (LPS), morphological and functional changes in thymus spleen subpopulation composition peripheral blood lymphocytes rats differing resistance to hypoxia were studied. It was demonstrated that level endotoxin serum after 3 hours LPS administration susceptible-to-hypoxia 64 times higher than control group, while tolerant-to-hypoxia animals it only 8 6 hours. After 24 injection, did C-reactive protein increase....
One of the factors contributing to colorectal cancer (CRC) development is inflammation, which mostly hypoxia-associated. This study aimed characterize morphological and molecular biological features colon tumors in mice that were tolerant susceptible hypoxia based on colitis-associated CRC (CAC). Hypoxia tolerance was assessed through a gasping time evaluation decompression chamber. month later, animals experimentally modeled for by intraperitoneal azoxymethane administration three dextran...