D. N. Khochanskiy

ORCID: 0000-0002-7153-6828
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About
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Research Areas
  • Gastrointestinal motility and disorders
  • Exercise and Physiological Responses
  • Cancer, Hypoxia, and Metabolism
  • Immune Response and Inflammation
  • Adipose Tissue and Metabolism
  • Thyroid Disorders and Treatments
  • Thermoregulation and physiological responses
  • High Altitude and Hypoxia
  • Transplantation: Methods and Outcomes
  • Prostate Cancer Treatment and Research
  • Intestinal Malrotation and Obstruction Disorders
  • Cardiac Arrest and Resuscitation
  • Mechanical Circulatory Support Devices
  • Stress Responses and Cortisol
  • Diet and metabolism studies
  • Vagus Nerve Stimulation Research
  • Gut microbiota and health
  • Infant Health and Development
  • Estrogen and related hormone effects
  • Microscopic Colitis
  • Nanoplatforms for cancer theranostics
  • Eicosanoids and Hypertension Pharmacology
  • Child Nutrition and Feeding Issues
  • Ion channel regulation and function
  • Hormonal and reproductive studies

Semmelweis University
2023-2024

Research Institute of Human Morphology
2017-2021

Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental conditions worldwide. There growing awareness that ASD highly comorbid with gastrointestinal distress and altered intestinal microbiome, host-microbiome interactions may contribute to disease symptoms. However, paucity knowledge on gut-brain axis signaling in autism constitutes an obstacle development precision microbiota-based therapeutics ASD. To this end, we explored between microbiota, gut physiology social...

10.1016/j.ebiom.2017.09.020 article EN cc-by-nc-nd EBioMedicine 2017-09-22

The aim of the study was to characterize severity systemic inflammatory response induced by lipopolysaccharide (LPS) in animals with different resistance levels hypoxia.Two three months old male Wistar rats (220-240 g) were divided according hypoxia tolerance a hypobaric chamber. After month, they injected intraperitoneally Escherichia coli LPS at dose 1.5 mg/kg. 3, 6 and 24 hours injection, we studied IL-1β, C-reactive protein (CRP) TGF-β serum, expression Hif-1α Nf-kb liver, morphological...

10.2147/jir.s194581 article EN cc-by-nc Journal of Inflammation Research 2019-03-01

Orthotopic heart transplantation (HTx) is a long-term surgical therapeutic approach for patients with end-stage failure. The objective of the present study was to uncover associations between altered thyroid hormone (TH) status and adverse outcomes after HTx.

10.1089/thy.2023.0628 article EN Thyroid 2024-04-13

On the model of systemic inflammatory response (SIRS), induced by lipopolysaccharide (LPS), morphological and functional changes in thymus spleen subpopulation composition peripheral blood lymphocytes rats differing resistance to hypoxia were studied. It was demonstrated that level endotoxin serum after 3 hours LPS administration susceptible-to-hypoxia 64 times higher than control group, while tolerant-to-hypoxia animals it only 8 6 hours. After 24 injection, did C-reactive protein increase....

10.1155/2019/7584685 article EN cc-by International Journal of Inflammation 2019-04-01

Background: Frailty has been proven to be associated with mortality after orthotopic heart transplantation (OHT). The aim of our study was determine the impact frailty on in current era using pretransplant mechanical cardiac support (MCS). Methods: We retrospectively calculated scores 471 patients undergoing OHT a single institution between January 2012 and August 2022. outcome all-cause mortality. Results: median survival time 1987 days (IQR: 1487 days) for all patients. In total, 266...

10.3390/biomedicines12051114 article EN cc-by Biomedicines 2024-05-17

Introduction. Stress is one of the factors contributing to gastrointestinal tract diseases development and exacerbating course tract. The cold factor most common stress in Russia. Therefore, aim our work was characterize immune responses colon morphological functional changes during male female C57BL/6 mice. Materials methods. We studied alterations subpopulation composition peripheral blood lymphocytes morphofunctional thymus, spleen, response a intermittent exposure 35-minute sessions for...

10.31088/cem2020.9.4.50-64 article EN CLINICAL AND EXPERIMENTAL MORPHOLOGY 2020-01-01
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