A5000175259- Circadian rhythm and melatonin
- Ultrasound and Hyperthermia Applications
- Skin Protection and Aging
- melanin and skin pigmentation
- Nanoparticle-Based Drug Delivery
- Tissue Engineering and Regenerative Medicine
- Ultrasound and Cavitation Phenomena
- Erythrocyte Function and Pathophysiology
- Lanthanide and Transition Metal Complexes
- Advanced Drug Delivery Systems
- Cardiovascular Function and Risk Factors
- Barrier Structure and Function Studies
- Elasticity and Material Modeling
- Microbial Inactivation Methods
- Advanced MRI Techniques and Applications
- ATP Synthase and ATPases Research
- Biochemical effects in animals
- Human Health and Disease
- MicroRNA in disease regulation
- Lipid Membrane Structure and Behavior
- Genetic and Kidney Cyst Diseases
- 3D Printing in Biomedical Research
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Cardiomyopathy and Myosin Studies
Research Institute of Human Morphology
2012-2023
Russian Scientific Center of Surgery
2023
Academy of Medical Sciences
2012-2015
Russian Academy of Sciences
2012-2013
University Medical Center Hamburg-Eppendorf
2012
Goethe University Frankfurt
2012
University Hospital Frankfurt
2012
Universität Hamburg
2012
Nanosystem (Russia)
2012
Moscow State University
2009-2011
Tissue spheroids have been proposed as building blocks in 3D biofabrication. Conventional magnetic force-driven 2D patterning of tissue requires prior cell labeling by nanoparticles, meanwhile a label-free approach for levitational assembly has introduced. Here we present first time report on rapid construct using scaffold-free, nozzle-free and levitation spheroids. Chondrospheres standard size, shape capable to fusion biofabricated from primary sheep chondrocytes non-adhesive technology....
Induced and frequently unwanted alterations in the mitochondrial structure functions are a key component of pathological cascade many kidney pathologies, including those associated with acute damage. One principal pathogenic elements causing dysfunction Acute Kidney Injury (AKI) is oxidative stress. After ischemia nephrotoxic action drugs, sepsis systemic inflammation most frequent causes AKI. As suffers from stress during sepsis, one promising approaches to alleviate such damaging...
Extracellular vesicles (EV) derived from stem cells have become an effective complement to the use in cell therapy of themselves, which has led explosion research into mechanisms vesicle formation and their action. There is evidence demonstrating presence mitochondrial components EV, but a definitive conclusion about whether EV contains fully functional mitochondria not yet been made. In this study, two fractions mesenchymal stromal (MSC) separated by size were examined. Flow cytometry...
The use of stem cells is part a strategy for the treatment large number diseases. However, source original extremely important and determines their therapeutic potential. Mesenchymal stromal (MSC) have proven effectiveness when used in pathological models. it remains an open question whether chronological age donor organism affects MSC. asymmetric division cells, result which some residential acquiring non-senile phenotype, means that possess intrinsic ability to preserve juvenile...
Enzyme-responsive liposomes release their cargo in response to pathologically increased levels of enzymes at the target site. We report herein an assembly phospholipase A2-responsive based on colchicinoid lipid prodrugs incorporated into bilayer nanosized vesicles. The were constructed addresses two important issues: (i) designed fit structure enzyme binding site; and (ii) concept lateral pressure profile was used design that introduce almost no distortions packing, thus ensuring...
ФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕЖДИСЦИПЛИНАРНЫЕ ТЕХНОЛОГИИ ■ Резюме Актуальность.Гипертрофическая кардиомиопатия (ГКМП) -распространенная генетическая патология миокарда.В исследованиях показана взаимосвязь гистопатологических изменений при ГКМП с клинической картиной и риском возникновения жизнеугрожающих аритмий, существуют данные о роли митохондриального генома в возникновении развитии ГКМП.Однако морфологического исследования ультраструктур миокарда литературе представлены...
Dietary restriction (DR) is the strategy ameliorating morbidity of various pathologies, including age-associated diseases. Acute kidney injury (AKI) remains a problem for elderly with DR being promising approach diminishing its consequences. We evaluated possible nephroprotective potential short-term in young and old rats. rats resulted pronounced beneficial effects normalizing lipid metabolism (triglycerides concentration, adiponectin level) activating autophagic-lysosomal system by...
Different from regular small molecule contrast agents, nanoparticle-based agents have a longer circulation time and can be modified with ligands to confer tissue-specific contrasting properties. We evaluated the tissue distribution of polymeric nanoparticles (NPs) prepared human serum albumin (HSA), loaded gadolinium–diethylenetriaminepentaacetic acid (Gd-DTPA) (Gd-HSA-NP), coated folic (FA) (Gd-HSA-NP-FA) in mice by magnetic resonance imaging (MRI). FA increases affinity Gd-HSA-NP...
Introduction. Despite the treatment methods’ improvement, brain glioblastoma (GB) patient survival remains at level of 12–14 months. In this regard, it is very relevant to optimize choice treat-ment recurrent GB, including using stereotactic radiosurgery (SRS). Materials and methods. Comparative analysis endothelial cells in capillaries blood vessels peritumoral zone (PZ) before (1 group – 32 capillaries) 12 14 months after (2 75 adjuvant external radiation therapy (AERT) was performed...
A study of the morphofunctional condition mice with transplantable melanoma B16 under influence a normal daylight regime, constant lighting and darkness was conducted. It shown that exposure to leads intensification proliferation cells, more significant growth spread tumor, development pronounced secondary changes, presence perivascular an increase in perineural invasion. At same time, keeping animals significantly reduced intensity proliferative process tumor lead regression absence signs...
To analyze cellular and subcellular disorders in the lung presence of HIV-associated tuberculosis.The investigators made a comprehensive morphological examination 25 autopsy specimens from patients who had died tuberculosis. Lung pieces foci caseous necrosis at its boundary adjacent segments macroscopically intact perifocal pulmonary were microscopically explored. Plain stains Ziehl-Neelsen histobacterioscopy used for light microscopy. An immunohistochemical study was conducted using...
Circadian rhythms of physiological processes, constantly being in a state dynamic equilibrium and plastically associated with changes environmental conditions, are the basis homeostasis an organism human other mammals. Violation circadian due to significant disturbances parameters main effectors (desynchronosis) leads development pathological conditions more severe course preexisting pathologies. We conducted study ultrastructure cells mice transplantable malignant melanoma B16 under...