A5004165426- Mesenchymal stem cell research
- Immune cells in cancer
- Liver physiology and pathology
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Reproductive System and Pregnancy
- Organ Transplantation Techniques and Outcomes
- Phagocytosis and Immune Regulation
- Endometriosis Research and Treatment
- Liver Disease Diagnosis and Treatment
- Periodontal Regeneration and Treatments
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Advanced Radiotherapy Techniques
- MicroRNA in disease regulation
- Bone Tissue Engineering Materials
- Glioma Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Neurogenesis and neuroplasticity mechanisms
- Immunotherapy and Immune Responses
- Uterine Myomas and Treatments
- Immune Response and Inflammation
- Cancer-related gene regulation
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation
2016-2025
Peoples' Friendship University of Russia
2017-2025
Research Institute of Human Morphology
2015-2025
Russian Scientific Center of Surgery
2007-2025
Institute of Molecular and Cell Biology
2023-2024
Pirogov Russian National Research Medical University
2012-2022
Ministry of Health of the Russian Federation
2012-2022
Research Centre for Medical Genetics
2018-2019
Smith College
2019
Syracuse University
2019
Abstract The aim of this study was to evaluate the efficacy hysteroscopically controlled injections autologous platelet-rich plasma (PRP) and endometrial cells as a treatment for infertile women with thin endometrium. enrolled 115 patients endometrium (< 7 mm at implantation window) infertility, who were divided into groups: Group 1 (the control) underwent conservative therapy; 2 received intraendometrial PRP instead 3 identical after 4 suspended in PRP. A single injection dose contained...
Abstract Background Mesenchymal stromal/stem cells derived from human umbilical cord (UC-MSCs) uniquely combine properties of embryonic and postnatal MSCs may be the most acceptable, safe, effective source for allogeneic cell therapy e.g. therapeutic angiogenesis. In this report we describe pro-angiogenic UC-MSCs as manifested in vitro . Methods were isolated Wharton’s jelly by enzymatic digestion. Presence soluble forms VEGF-A UC-MSC-conditioned media was measured ELISA. Effects conditioned...
Aim This study presents an analysis (efficacy and toxicity) of outcomes in patients with esthesioneuroblastoma after pencil beam proton therapy a fixed beamline the upright position. Background Esthesioneuroblastoma (ENB) is extremely rare tumor sinonasal area located critical proximity to vital structures. Proton (PT) often considered optimal radiation treatment for head-and-neck tumors, although limited availability. Upright PT delivered using rotating chair fairly promising option....
This review discusses the importance of homeostasis with a particular emphasis on acid-base (AB) balance, crucial aspect pH regulation in living systems. Two primary organ systems correct deviations from standard balance: respiratory system via gas exchange and kidneys proton/bicarbonate secretion reabsorption. Focusing kidney functions, we describe complexity renal architecture its challenges for experimental research. We address specific roles different nephron segments (the proximal...
Infective endocarditis (IE) is characterized by the difficulty of diagnosis, treatment and risk assessment an unfavorable prognosis. Currently there are no approved scales calculators for complications death that help practitioner make decisions, especially in patients with isolated right-sided IE. For IE, timing successful surgical remains uncertain. Previously developed (Italian Rizzi calculator French Hubert) poorly validated a wide population One required parameters determination...
Aim. To study the cytokine profile of macrophages in valve tissues operated patients with infective endocarditis (IE), its correlation inflammatory markers for optimization assessment IE activity. Material and methods. There were prospectively included 25 adult active (2015Duke criteria) 24 non-IE valvular heart disease admitted cardiac surgery (2021-2022). Laboratory instrumental examination was conducted, including pathogen verification, as well by means Real-Time PCR blood/tissues...
In this study, we prepared hydrogel scaffolds for tissue engineering by computer-assisted extrusion three-dimensional (3D) printing with photocured (λ = 445 nm) hyaluronic acid glycidyl methacrylate (HAGM). The developed product was compared the polylactic-co-glycolic (PLGA) generated means of original antisolvent 3D methodology. cytotoxicity and cytocompatibility were analyzed in vitro 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tests, flow cytometry, scanning electron...
The evolution of regenerative capacity in multicellular animals represents one the most complex and intriguing problems biology. How could such a seemingly advantageous trait as self-repair become consistently attenuated by evolution? This review article examines concept origin nature regeneration, its connection with processes embryonic development asexual reproduction, well mechanisms tissue homeostasis. presents variety classical modern hypotheses explaining different trends which is not...
We studied the gene-expression patterns in specimens of tumor and peritumor tissue biopsies 26 patients with head neck carcinomas depending on smoking status. Histological immunohistochemical examinations verified that all tumors belonged to “classical” subgroup carcinomas, HPV-negative status was confirmed. The expression 28 tumor-associated genes determined by RT-PCR independent patients’ sex or age, TNM status, degree differentiation, localization. Moreover, tissue, none were...
Transplantation of various types stem cells as a possible therapy for stroke has been tested years, and the results are promising. Recent investigations have shown that administration conditioned media obtained after cell cultivation can also be effective in central nervous system pathology (hypothesis their paracrine action). The aim this study was to evaluate therapeutic effects medium hiPSC-derived glial neuronal progenitor rat middle cerebral artery occlusion model ischemic stroke....