A5028991702- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Orthopedic Infections and Treatments
- Vasculitis and related conditions
- Lipoproteins and Cardiovascular Health
- Ultrasound in Clinical Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Aortic and Vascular Conditions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Blood disorders and treatments
- Inflammatory mediators and NSAID effects
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 and healthcare impacts
- Central Venous Catheters and Hemodialysis
- Inflammasome and immune disorders
- Heart rate and cardiovascular health
Peoples' Friendship University of Russia
2016-2025
City Clinical Hospital
2018-2024
Al-Sabah Hospital
2023
Russian Society of Cardiology
2022
Aim . Enteric-coated acetylsalicylic acid (ASA) is released more slowly and absorbed in smaller quantities over a longer period of time, which may lead to bioavailability antiplatelet effect decrease compared conventional ASA. Patients with diabetes are characterized by increased platelet reactivity reduced pharmacodynamic response ASA individuals without diabetes. It seems rational test the hypothesis that use stomach be effective patients type 2 mellitus (T2D) stable coronary artery...
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Infective endocarditis (IE) is characterized by the difficulty of diagnosis, treatment and risk assessment an unfavorable prognosis. Currently there are no approved scales calculators for complications death that help practitioner make decisions, especially in patients with isolated right-sided IE. For IE, timing successful surgical remains uncertain. Previously developed (Italian Rizzi calculator French Hubert) poorly validated a wide population One required parameters determination...
Background. There is a lack of data on the incidence aspirin nonresponsiveness and efficacy different forms ASA in patients with diabetes. Aim. To evaluate buffered versus enteric-coated based frequency high residual platelet reactivity (HRPR) as measured by VerifyNow Aspirin Test chronic coronary syndrome (CCS) type 2 diabetes (T2D). Material methods . The single-center observational parallel-group comparative study (CASCADE) included over 18 years age CCS T2D who were prescribed form...
Aim. To study the cytokine profile of macrophages in valve tissues operated patients with infective endocarditis (IE), its correlation inflammatory markers for optimization assessment IE activity. Material and methods. There were prospectively included 25 adult active (2015Duke criteria) 24 non-IE valvular heart disease admitted cardiac surgery (2021-2022). Laboratory instrumental examination was conducted, including pathogen verification, as well by means Real-Time PCR blood/tissues...
Aim To study the role of early blood tests using polymerase chain reaction (PCR) (before or at initial stages antibacterial therapy, within first 24-48 hours after diagnosis) for diagnosis infective endocarditis (IE) and improvement etiological algorithm. Material methods The included 154 patients with confirmed IE (DUKE, 2015) who underwent standard microbiological (culture) a simultaneous molecular biological test (PCR study/sequencing) on same type material stage primary diagnosis....
Background Coagulation system is heavily involved into the process of infective endocarditis (IE) vegetation formation and can facilitate further embolization. In this study we aimed to assess coagulation platelet state in IE implementing a wide range standard global laboratory assays. We also aim determine whether prothrombotic genetic polymorphisms play any role embolization mortality patients. Methods 37 patients with were enrolled study. was assessed using assays (activated partial...
to investigate clinical properties of course and outcomes infective endocarditis (IE) depending on source infection, find predictors mortality in a Moscow general hospital.We included this study 176 patients with definite possible (the Duke criteria), admitted our hospital 2010-2017. Patients were divided three groups according infection. All underwent standard laboratory assessment, echocardiography, blood culture test combined PCR sequencing. Inhospital 1-year outcome evaluated.Among IE...
The assessment of platelet dysfunction is usually used by hematologists to diagnose inherited (such as Bernard-Soulier syndrome, platelet-type-von Willebrand disease, Glanzmann thrombasthenia, etc.), and acquired (symptomatic) disorders (in hemoblastoses, uremia, liver cirrhosis, well predict the risk intraoperative bleeding in these groups patients. Later, laboratory function tests began be cardiologists, first experimental clinical studies. In further years, attempts were made introduce...
To investigate the specific features of conventional bacteriological methods and current molecular biological techniques for etiological diagnosis infective endocarditis (IE).Examinations were made in 53 patients treated at City Clinical Hospital Sixty-Four, Moscow Healthcare Department, 2012-2015 who underwent simultaneous (polymerase chain reaction (PCR) or PCR with further sequencing) examinations blood resected cardiac valve tissues.The investigation included (31 men; median age, 62...
This document is a consensus of Russian Specialists in Heart Failure, Society Cardiology, Association Ultrasound Diagnostics Medicine and for the Prevention Noncommunicable Diseases. In definition focus ultrasound stated discussed when it can be used cardiology practice Federation.
Advances in the diagnosis and treatment of patients with infectious endocarditis are limited by high frequency cases an unknown etiology imperfection microbiological (cultural) methods. To overcome these problems new approaches to identification pathogens were introduced, which allowed achieving certain positive results. However, it should be noted that despite wide variety diagnostic tools currently used, there is no ideal method for etiological laboratory endocarditis. The article...
The guidelines have been developed for internists, general practitioners, emergency physicians, and paramedics. are based on expert consensus papers, accumulated clinical scientific experience. methodology organizing conducting ultrasound-assisted examinations is described in detail. Algorithms diagnosing the main syndromes internal medicine practice presented to help practitioner. Particular attention paid of ultrasoundassisted examinations. These will be interest doctors, heads medical...
Background. If infective endocarditis (IE) is suspected, the determination of etiology fundamental importance for verification disease and appointment effective therapy. Microbiological diagnostic features are important, but they often need to be supplemented by culture-independent studies pathological agents. Aim. To investigate advantage value quantitative analysis molecular biological methods (polymerase chain reaction PCR, sequencing) in addition microbiological examination whole venous...
The correction of blood coagulation impairments a bleeding or thrombotic nature employs standard protocols where the type drug, its dose and administration regime are stated. However, for group patients, such an approach may be ineffective, personalized therapy adjustment is needed. Laboratory hemostasis tests used to control efficacy therapy, which expensive time-consuming. Computer simulations become inexpensive fast alternative real tests. In this work, we propose procedure numerically...
Materials and methods: a prospective non-randomized pilot multicenter study of the informativeness clinical significance hemostasis laboratory tests in 1210 patients with COVID-19 disease course, including favorable unfavorable outcomes, was performed. Hemostasis assessed using clotting D-dimer concentration, thromboelastography (TEG) thrombodynamics (TD). Results: comparison parameters picture showed that 75% have pronounced activation plasma coagulation system upon admission to hospital....
Current infectious endocarditis (IE) is characterized by changes in its etiological and epidemiological profiles associated with increased incidence of IE undetermined etiology. This requires a search for ways to enhance the effectivity diagnosis. Microbiologistics along high-tech methods becomes decisively important identifying pathogen studying cultures blood tissues from affected heart valve. determines timely diagnosis treatment be introduced medical practice as component personalized...
The issue of antithrombotic therapy in patients with infective endocarditis has been studied for over 75 years. During that time studying pathogenesis the disease and its embolic complications, lead to introduction concept “immunothrombosis”. That mechanism allows agents (mostly bacteria) be cloaked from immune system multiply freely, leading growth vegetation, thus resulting higher chance fragmentation. Small-scale experimental clinical studies on correction hemostatic disorders...
Aim . To study the impact of coronavirus disease 2019 (COVID-19) pandemic on hospitalization rates, diagnosis, and outcomes infective endocarditis (IE) with a subanalysis IE course in combination COVID-19. Material methods This prospective cohort included 168 patients definite or probable (DUKE 2015) hospitalized V.V. Vinogradov City Clinical Hospital from July 2017 to 2022. All underwent conventional examination accordance current clinical guidelines. We studied clinical, paraclinical...
The history of the study infective endocarditis in Russia is described article.
Aim. To study the features of macrophages in tissues resected valves operated patients with infective endocarditis (IE), their significance and interaction inflammatory markers to improve effectiveness IE diagnosis. Materials methods. Prospectively research included 25 adult active (Duke criteria 2015) 24 heart defects without IE, hospitalized a cardiosurgical hospital Moscow (2021–2022). A standard laboratory instrumental examination was carried out for diagnosis including etiological...
Aim . To investigate the state of platelet and plasma components hemostasis in patients with myocardial infarction non-obstructive coronary arteries (MINOCA). Material methods The study included 42 non-ST-segment elevation (NSTEMI): MINOCA (n=24) MI-CAD (n=18). Platelet aggregation ability response to activation was evaluated using Solar AP2110 LASCA aggregometers. functional activity calcium signaling were assessed flow cytometry methods. component hemostasis, addition routine coagulation...